Cross-species comparison of CpG density in the promoter regions of protein kinase oncogenes

Article

Pioth, Gabriel G., Zhao, Kong-Nan and Liu, Guang B.. 2015. "Cross-species comparison of CpG density in the promoter regions of protein kinase oncogenes." Bioengineering and Bioscience. 3 (3), pp. 29-38. https://doi.org/10.13189/bb.2015.030301
Article Title

Cross-species comparison of CpG density in the promoter regions of protein kinase oncogenes

Article CategoryArticle
AuthorsPioth, Gabriel G. (Author), Zhao, Kong-Nan (Author) and Liu, Guang B. (Author)
Journal TitleBioengineering and Bioscience
Journal Citation3 (3), pp. 29-38
Number of Pages10
Year2015
Place of PublicationUSA
Digital Object Identifier (DOI)https://doi.org/10.13189/bb.2015.030301
Web Address (URL)http://www.hrpub.org/download/20150620/BB1-10103910.pdf
Abstract

In this report, we investigated CpG density occurred in promoter regions (PRs) and downstream flanking regions (DFR) of 61 human protein kinase oncogenes (PKOs), together with other three species: chimpanzee, mouse and horse. The quantified numbers of CpGs in the PRs of human PKOs were much higher than those of chimpanzee, mouse and horse, suggesting that the CpG density changes among the four species are associated with species evolution. Human PKOs with relatively high number of CpGs in the PRs showed stronger gene expression than the mouse PKOs in tumour tissues, but not in normal tissues. Furthermore, human PKOs with extremely high density of CpGs in the PRs exhibited much lower expression in tumour tissues than in normal tissues. Our data initially suggest that the occurrence and density of CpGs in the PRs of PKOs play an important role in regulating gene expression associated with the tumorigenesis. Thus, further improvement of our understanding of the density and spatial arrangement of CpGs in the PRs of PKOs and other oncogenes involved in tumorigenesis is very important for providing preventive and therapeutic strategies for human cancer.

KeywordsCpG Island , Protein Kinase Oncogene , Oncogenesis , Promoter Region, Transcription Start Sites
ANZSRC Field of Research 2020321103. Cancer genetics
310505. Gene expression (incl. microarray and other genome-wide approaches)
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Byline AffiliationsSchool of Health and Wellbeing
University of Queensland
Institution of OriginUniversity of Southern Queensland
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