Genetic contribution to individual variation in binocular rivalry rate

Article

Miller, Steven M., Hansell, Narelle K., Ngo, Trung T., Liu, Guang B., Pettigrew, John D., Martin, Nicholas G. and Wright, Margaret J.. 2010. "Genetic contribution to individual variation in binocular rivalry rate." University of Adelaide. 107 (6), pp. 2664-2668. https://doi.org/10.1073/pnas.0912149107
Article Title

Genetic contribution to individual variation in binocular rivalry rate

Article CategoryArticle
AuthorsMiller, Steven M. (Author), Hansell, Narelle K. (Author), Ngo, Trung T. (Author), Liu, Guang B. (Author), Pettigrew, John D. (Author), Martin, Nicholas G. (Author) and Wright, Margaret J. (Author)
Journal TitleUniversity of Adelaide
Journal Citation107 (6), pp. 2664-2668
Number of Pages5
Year2010
Place of PublicationWashington, DC, USA
Digital Object Identifier (DOI)https://doi.org/10.1073/pnas.0912149107
Web Address (URL)http://www.pnas.org/cgi/doi/10.1073/pnas.0912149107
Abstract

Binocular rivalry occurs when conflicting images are presented in corresponding locations of the two eyes. Perception alternates between the images at a rate that is relatively stable within individuals but that varies widely between individuals. The determinants of this variation are unknown. In addition, slow binocular rivalry has been demonstrated in bipolar disorder, a psychiatric condition with high heritability. The present study therefore examined whether there is a genetic contribution to individual variation in binocular rivalry rate. We employed the twin method and studied both monozygotic (MZ) twins (n = 128 pairs) who are genetically identical, and dizygotic (DZ) twins (n = 220 pairs) who share roughly half their genes. MZ and DZ twin correlations for binocular rivalry rate were 0.51 and 0.19, respectively. The bestfitting
genetic model showed 52% of the variance in binocular
rivalry rate was accounted for by additive genetic factors. In contrast, nonshared environmental influences accounted for 18% of the variance, with the remainder attributed to measurement error. This study therefore demonstrates a substantial genetic contribution to individual variation in binocular rivalry rate. The results support the vigorous pursuit of genetic and molecular studies of binocular rivalry and further characterization of slow binocular
rivalry as an endophenotype for bipolar disorder.

Keywordsperceptual rivalry; bipolar disorder; endophenotype; genetics; twins
ANZSRC Field of Research 2020310511. Neurogenetics
510299. Atomic, molecular and optical physics not elsewhere classified
321204. Vision science
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Byline AffiliationsMonash University
Queensland Institute of Medical Research, Australia
Centre for Systems Biology
University of Queensland
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