Estrogen-induced cholestasis: pathogenesis and therapeutic implications

Article

Chen, Jiezhong, Zhao, Kong-Nan and Liu, Guang Bin. 2013. "Estrogen-induced cholestasis: pathogenesis and therapeutic implications." Hepato-Gastroenterology: current medical and surgical trends. 60 (126), pp. 1296-1299. https://doi.org/10.5754/hge121061
Article Title

Estrogen-induced cholestasis: pathogenesis and therapeutic implications

ERA Journal ID16194
Article CategoryArticle
AuthorsChen, Jiezhong (Author), Zhao, Kong-Nan (Author) and Liu, Guang Bin (Author)
Journal TitleHepato-Gastroenterology: current medical and surgical trends
Journal Citation60 (126), pp. 1296-1299
Number of Pages4
Year2013
Place of PublicationStuttgart, Germany
ISSN0001-5822
0172-6390
0300-970X
Digital Object Identifier (DOI)https://doi.org/10.5754/hge121061
Web Address (URL)https://www.hepatogastroenterology.org/
Abstract

Cholestasis syndromes characterised by impairment of bile formation and secretion are caused by many diseases. Estrogen-induced cholestasis among the cholestasis syndromes is a very common form. Based on the molecular studies of bile formation and transportation, a significant advancement has been achieved in understanding the mechanism of the disease. Estrogen can inhibit bile acids transportation from hepatocytes into bile canaliculi by interfering with the bile salt export pump and multidrug resistance-associated transporter 2 as well. It also inhibits Na+-taurocholate cotransporting polypeptide and Na+-independent organic anion-transporting polypeptides in the basolateral membrane of hepatocytes to interfere with the uptake of bile acids. Thus, co-treatment strategy can be considered which combines nuclear receptor inducers and cAMP enhancer to increase bile acids transporters activities, and the agents to reduce serum estrogen concentration and its receptor binding, and to reduce bile acids in enterohepatic circulation.

Keywordsestrogen; cholestasis; multidrug resistance-associated transporter; bile acids
ANZSRC Field of Research 2020320504. Medical biochemistry - lipids
320209. Gastroenterology and hepatology
320603. Medical molecular engineering of nucleic acids and proteins
Public Notes

© H.G.E. Update Medical Publishing S.A., Athens. Permanent restricted access to published version due to publisher copyright policy.

Byline AffiliationsCentre for Systems Biology
Institution of OriginUniversity of Southern Queensland
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