Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide
Article
Article Title | Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide |
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ERA Journal ID | 14774 |
Article Category | Article |
Authors | Xu, Youhong (Author), Chen, Austen Y. (Author), Fry, Scott R. (Author), Barrow, Russell A. (Author), Marshall, Raymond L. (Author) and Mukkur, T. K. S. (Author) |
Journal Title | International Immunopharmacology |
Journal Citation | 7 (4), pp. 515-523 |
Year | 2007 |
Place of Publication | United Kingdom |
ISSN | 1567-5769 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.intimp.2006.12.008 |
Web Address (URL) | https://www.sciencedirect.com/science/article/pii/S1567576906003869 |
Abstract | [Abstract]: Gavage of mice, immunised with an inactivated S. typhimurium vaccine, with Andrographis paniculata extract [APE] or andrographolide [AND] resulted in an enhancement of Salmonella-specific antibody response and induction of cell-mediated response against salmonellosis. Mice were vaccinated with either one or two doses of killed S. typhimurium vaccine and fed two different quantities of APE or AND, for 14 days in mice immunised with one dose of the vaccine, and for 28 days in mice immunised with two doses of vaccine, respectively. Both APE and AND were found to enhance IgG antibody levels against S. typhimurium, the enhancement being statistically significant in mice receiving two doses of the vaccine. Splenocyte cultures, prepared from mice immunised with the killed Salmonella vaccine and treated with APE or AND, showed a remarkable increase in the production IFN-γ following stimulation with the bacterial lysate, indicating an induction of Salmonella-specific cell-mediated response/immune response. |
Keywords | Andrographis paniculata; andrographolide; immunomodulatory; antibody response; cell-mediated immunity |
ANZSRC Field of Research 2020 | 320404. Cellular immunology |
Public Notes | File reproduced in accordance with the copyright policy of the publisher/author. |
Byline Affiliations | Faculty of Sciences |
Department of Biological and Physical Sciences |
https://research.usq.edu.au/item/9y499/modulation-of-immune-response-in-mice-immunised-with-an-inactivated-salmonella-vaccine-and-gavaged-with-andrographis-paniculata-extract-or-andrographolide
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