Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide

Article


Xu, Youhong, Chen, Austen Y., Fry, Scott R., Barrow, Russell A., Marshall, Raymond L. and Mukkur, T. K. S.. 2007. "Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide." International Immunopharmacology. 7 (4), pp. 515-523. https://doi.org/10.1016/j.intimp.2006.12.008
Article Title

Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide

ERA Journal ID14774
Article CategoryArticle
AuthorsXu, Youhong (Author), Chen, Austen Y. (Author), Fry, Scott R. (Author), Barrow, Russell A. (Author), Marshall, Raymond L. (Author) and Mukkur, T. K. S. (Author)
Journal TitleInternational Immunopharmacology
Journal Citation7 (4), pp. 515-523
Year2007
Place of PublicationUnited Kingdom
ISSN1567-5769
Digital Object Identifier (DOI)https://doi.org/10.1016/j.intimp.2006.12.008
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S1567576906003869
Abstract

[Abstract]: Gavage of mice, immunised with an inactivated S. typhimurium vaccine, with Andrographis paniculata extract [APE] or andrographolide [AND] resulted in an enhancement of Salmonella-specific antibody response and induction of cell-mediated response against salmonellosis. Mice were vaccinated with either one or two doses of killed S. typhimurium vaccine and fed two different quantities of APE or AND, for 14 days in mice immunised with one dose of the vaccine, and for 28 days in mice immunised with two doses of vaccine, respectively. Both APE and AND were found to enhance IgG antibody levels against S. typhimurium, the enhancement being statistically significant in mice receiving two doses of the vaccine. Splenocyte cultures, prepared from mice immunised with the killed Salmonella vaccine and treated with APE or AND, showed a remarkable increase in the production IFN-γ following stimulation with the bacterial lysate, indicating an induction of Salmonella-specific cell-mediated response/immune response.

KeywordsAndrographis paniculata; andrographolide; immunomodulatory; antibody response; cell-mediated immunity
ANZSRC Field of Research 2020320404. Cellular immunology
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Byline AffiliationsFaculty of Sciences
Department of Biological and Physical Sciences
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