The development and evaluation of DNA vaccines against whooping cough using a murine respiratory model of infection

PhD Thesis


Fry, Scott Robert. 2006. The development and evaluation of DNA vaccines against whooping cough using a murine respiratory model of infection. PhD Thesis Doctor of Philosophy. University of Southern Queensland.
Title

The development and evaluation of DNA vaccines against whooping cough using a murine respiratory model of infection

TypePhD Thesis
Authors
AuthorFry, Scott Robert
SupervisorMukkur, T. K. S.
Daggard, Grant
Institution of OriginUniversity of Southern Queensland
Qualification NameDoctor of Philosophy
Number of Pages423
Year2006
Abstract

In this study, a suite of single antigen DNA vaccines, combination DNA vaccines and dual modality vaccines, were developed and evaluated for their potential to induce humoral and cell-mediated immune responses, and protective efficacy against Bordetella pertussis, the aetiological agent of whooping cough, using the mouse respiratory challenge model.

KeywordsDNA vaccines; whooping cough; Bordetella pertussis
ANZSRC Field of Research 2020320404. Cellular immunology
Byline AffiliationsDepartment of Biological and Physical Sciences
Permalink -

https://research.usq.edu.au/item/9yy39/the-development-and-evaluation-of-dna-vaccines-against-whooping-cough-using-a-murine-respiratory-model-of-infection

Download files


Published Version
Fry_2006_whole.pdf
File access level: Anyone

  • 1981
    total views
  • 669
    total downloads
  • 4
    views this month
  • 3
    downloads this month

Export as

Related outputs

Immunological response to parenteral vaccination with recombinant hepatitis B virus surface antigen virus-like particles expressing Helicobacter pylori KatA epitopes in a murine H. pylori challenge model
Kotiw, Michael, Johnson, Megan, Pandey, Manisha, Fry, Scott, Hazell, Stuart L., Netter, Hans J., Good, Michael F. and Olive, Colleen. 2012. "Immunological response to parenteral vaccination with recombinant hepatitis B virus surface antigen virus-like particles expressing Helicobacter pylori KatA epitopes in a murine H. pylori challenge model ." Clinical and Vaccine Immunology. 19 (2), pp. 268-276. https://doi.org/10.1128/CVI.05295-11
Parenteral immunization of mice with a genetically inactivated pertussis toxin DNA vaccine induces cell-mediated immunity and protection
Fry, Scott R., Chen, Austen Y., Daggard, Grant and Mukkur, Trilochan K. S.. 2008. "Parenteral immunization of mice with a genetically inactivated pertussis toxin DNA vaccine induces cell-mediated immunity and protection." Journal of Medical Microbiology. 57 (1), pp. 28-35. https://doi.org/10.1099/jmm.0.47527-0
Evaluation of immune response to recombinant potential protective antigens of Mycoplasma hyopneumoniae delivered as cocktail DNA and/or recombinant protein vaccines in mice
Chen, Austen Y., Fry, Scott R., Daggard, Grant E. and Mukkur, Trilochan K. S.. 2008. "Evaluation of immune response to recombinant potential protective antigens of Mycoplasma hyopneumoniae delivered as cocktail DNA and/or recombinant protein vaccines in mice." Vaccine. 26 (34), pp. 4372-4378. https://doi.org/10.1016/j.vaccine.2008.06.005
Comparative immunogenicity of M. hyopneumoniae NrdF encoded in different expression systems delivered orally via attenuated S. typhimurium aroA in mice
Chen, Austen Y., Fry, Scott Robert, Forbes-Faulkner, Judy, Daggard, Grant and Mukkur, T. K. S.. 2006. "Comparative immunogenicity of M. hyopneumoniae NrdF encoded in different expression systems delivered orally via attenuated S. typhimurium aroA in mice." Veterinary Microbiology. 114 (3-4), pp. 252-259. https://doi.org/10.1016/j.vetmic.2005.12.009
Evaluation of the immunogenicity of the P97R1 adhesin of Mycoplasma hyopneumoniae as a mucosal vaccine in mice
Chen, Austen Y., Fry, Scott R., Forbes-Faulkner, Judy, Daggard, Grant and Mukkur, T. K. S.. 2006. "Evaluation of the immunogenicity of the P97R1 adhesin of Mycoplasma hyopneumoniae as a mucosal vaccine in mice." Journal of Medical Microbiology. 55 (7), pp. 923-929. https://doi.org/10.1099/jmm.0.46088-0
Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide
Xu, Youhong, Chen, Austen Y., Fry, Scott R., Barrow, Russell A., Marshall, Raymond L. and Mukkur, T. K. S.. 2007. "Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide." International Immunopharmacology. 7 (4), pp. 515-523. https://doi.org/10.1016/j.intimp.2006.12.008
Exploring the potential for dual vaccination against Hepatitis B virus and Helicobacter pylori using a recombinant virus like particle
Kotiw, Michael, Olive, C., Johnson, Megan, Pandy, M., Fry, Scott Robert, Hazell, Stuart L., Netter, H. and Good, M.. 2006. "Exploring the potential for dual vaccination against Hepatitis B virus and Helicobacter pylori using a recombinant virus like particle." Sirtori, Patrizia (ed.) 6th National Congress of the Italian Society of Virology - a joint meeting with the Virus Group of the Society for General Microbiology (UK). Orvieto, Italy 18 - 20 Sep 2006 Italy.
A metabolite-deficient mutant of Bordetella pertussis that induces secretory IgA and cell-mediated immunity in mice vaccinated by the intranasal route
Mukkur, T. K. S., Cornford-Nairn, Renee A., Rossetti, T., Kershaw, S., Fry, Scott Robert, Xu, Youhong and Daggard, Grant A.. 2005. "A metabolite-deficient mutant of Bordetella pertussis that induces secretory IgA and cell-mediated immunity in mice vaccinated by the intranasal route." Fang, Ferric C. (ed.) 105th American Society for Microbiology: General Meeting. Atlanta, Georgia 05 - 09 Jun 2005 Washington.