Immunological response to parenteral vaccination with recombinant hepatitis B virus surface antigen virus-like particles expressing Helicobacter pylori KatA epitopes in a murine H. pylori challenge model

Article

Kotiw, Michael, Johnson, Megan, Pandey, Manisha, Fry, Scott, Hazell, Stuart L., Netter, Hans J., Good, Michael F. and Olive, Colleen. 2012. "Immunological response to parenteral vaccination with recombinant hepatitis B virus surface antigen virus-like particles expressing Helicobacter pylori KatA epitopes in a murine H. pylori challenge model ." Clinical and Vaccine Immunology. 19 (2), pp. 268-276. https://doi.org/10.1128/CVI.05295-11
Article Title

Immunological response to parenteral vaccination with recombinant hepatitis B virus surface antigen virus-like particles expressing Helicobacter pylori KatA epitopes in a murine H. pylori challenge model

ERA Journal ID15550
Article CategoryArticle
AuthorsKotiw, Michael, Johnson, Megan, Pandey, Manisha, Fry, Scott, Hazell, Stuart L., Netter, Hans J., Good, Michael F. and Olive, Colleen
Journal TitleClinical and Vaccine Immunology
Journal Citation19 (2), pp. 268-276
Number of Pages9
Year2012
Place of PublicationWashington, DC. United States
ISSN1071-412X
1556-679X
1556-6811
Digital Object Identifier (DOI)https://doi.org/10.1128/CVI.05295-11
Web Address (URL)http://cdli.asm.org/content/19/2/268
Abstract

Virus-like particles (VLPs) based on the small envelope protein of hepatitis B virus (HBsAg-S) are immunogenic at the B- and T-cell level. In this study, we inserted overlapping sequences encoding the carboxy terminus of the Helicobacter pylori katA gene product into HBsAg-S. The HBsAg-S–KatA fusion proteins were able to assemble into secretion-competent VLPs (VLP-KatA). The VLP-KatA proteins were able to induce KatA-specific antibodies in immunized mice. The mean total IgG antibody titers 41 days post-primary immunization with VLP-KatA (2.3 × 103) were significantly greater (P < 0.05) than those observed for vaccination with VLP alone (5.2 × 102). Measurement of IgG isotypes revealed responses to both IgG1 and IgG2a (mean titers, 9.0 × 104 and 2.6 × 104, respectively), with the IgG2a response to vaccination with VLP-KatA being significantly higher than that for mice immunized with KatA alone (P < 0.05). Following challenge of mice with H. pylori, a significantly reduced bacterial load in the gastric mucosa was observed (P < 0.05). This is the first report describing the use of VLPs as a delivery vehicle for H. pylori antigens.

Keywordsaluminum hydroxide; bacterial protein; epitope; hepatitis B surface antigen; hybrid protein; immunoglobulin G1 antibody; immunoglobulin G2a antibody; KatA protein; recombinant Hepatitis B virus surface antigen Helicobacter pylori KatA fusion protein virus like particle vaccine; unclassified drug; virus like particle vaccine
ANZSRC Field of Research 2020320402. Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)
320705. Medical virology
320209. Gastroenterology and hepatology
Public Notes

Published ahead of print 28 December 2011

Byline AffiliationsCentre for Systems Biology
Griffith University
University of Queensland
Monash University
Queensland Institute of Medical Research, Australia
Institution of OriginUniversity of Southern Queensland
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https://research.usq.edu.au/item/q1634/immunological-response-to-parenteral-vaccination-with-recombinant-hepatitis-b-virus-surface-antigen-virus-like-particles-expressing-helicobacter-pylori-kata-epitopes-in-a-murine-h-pylori-challenge

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