Immunological response to parenteral vaccination with recombinant hepatitis B virus surface antigen virus-like particles expressing Helicobacter pylori KatA epitopes in a murine H. pylori challenge model

Article

Kotiw, Michael, Johnson, Megan, Pandey, Manisha, Fry, Scott, Hazell, Stuart L., Netter, Hans J., Good, Michael F. and Olive, Colleen. 2012. "Immunological response to parenteral vaccination with recombinant hepatitis B virus surface antigen virus-like particles expressing Helicobacter pylori KatA epitopes in a murine H. pylori challenge model ." Clinical and Vaccine Immunology. 19 (2), pp. 268-276. https://doi.org/10.1128/CVI.05295-11
Article Title

Immunological response to parenteral vaccination with recombinant hepatitis B virus surface antigen virus-like particles expressing Helicobacter pylori KatA epitopes in a murine H. pylori challenge model

ERA Journal ID15550
Article CategoryArticle
AuthorsKotiw, Michael, Johnson, Megan, Pandey, Manisha, Fry, Scott, Hazell, Stuart L., Netter, Hans J., Good, Michael F. and Olive, Colleen
Journal TitleClinical and Vaccine Immunology
Journal Citation19 (2), pp. 268-276
Number of Pages9
Year2012
Place of PublicationWashington, DC. United States
ISSN1071-412X
1556-679X
1556-6811
Digital Object Identifier (DOI)https://doi.org/10.1128/CVI.05295-11
Web Address (URL)http://cdli.asm.org/content/19/2/268
Abstract

Virus-like particles (VLPs) based on the small envelope protein of hepatitis B virus (HBsAg-S) are immunogenic at the B- and T-cell level. In this study, we inserted overlapping sequences encoding the carboxy terminus of the Helicobacter pylori katA gene product into HBsAg-S. The HBsAg-S–KatA fusion proteins were able to assemble into secretion-competent VLPs (VLP-KatA). The VLP-KatA proteins were able to induce KatA-specific antibodies in immunized mice. The mean total IgG antibody titers 41 days post-primary immunization with VLP-KatA (2.3 × 103) were significantly greater (P < 0.05) than those observed for vaccination with VLP alone (5.2 × 102). Measurement of IgG isotypes revealed responses to both IgG1 and IgG2a (mean titers, 9.0 × 104 and 2.6 × 104, respectively), with the IgG2a response to vaccination with VLP-KatA being significantly higher than that for mice immunized with KatA alone (P < 0.05). Following challenge of mice with H. pylori, a significantly reduced bacterial load in the gastric mucosa was observed (P < 0.05). This is the first report describing the use of VLPs as a delivery vehicle for H. pylori antigens.

Keywordsaluminum hydroxide; bacterial protein; epitope; hepatitis B surface antigen; hybrid protein; immunoglobulin G1 antibody; immunoglobulin G2a antibody; KatA protein; recombinant Hepatitis B virus surface antigen Helicobacter pylori KatA fusion protein virus like particle vaccine; unclassified drug; virus like particle vaccine
ANZSRC Field of Research 2020320402. Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)
320705. Medical virology
320209. Gastroenterology and hepatology
Public Notes

Published ahead of print 28 December 2011

Byline AffiliationsCentre for Systems Biology
Griffith University
University of Queensland
Monash University
Queensland Institute of Medical Research, Australia
Institution of OriginUniversity of Southern Queensland
Permalink -

https://research.usq.edu.au/item/q1634/immunological-response-to-parenteral-vaccination-with-recombinant-hepatitis-b-virus-surface-antigen-virus-like-particles-expressing-helicobacter-pylori-kata-epitopes-in-a-murine-h-pylori-challenge

Log in to edit
  • 1964
    total views
  • 9
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

They're Only Human! Tension and Stress Predict Performance of Softball Umpires in National Championships
Houison, Ronald J., Lamont-Mills, Andrea, Kotiw, Michael and Terry, Peter C.. 2025. "They're Only Human! Tension and Stress Predict Performance of Softball Umpires in National Championships." Sports. 13 (2). https://doi.org/10.3390/sports13020035
Strike 3 … Out! Investigating Pre-Game Moods, Performance, and Mental Health of Softball Umpires
Houison, Ronald J., Lamont-Mills, Andrea, Kotiw, Michael and Terry, Peter C.. 2024. "Strike 3 … Out! Investigating Pre-Game Moods, Performance, and Mental Health of Softball Umpires." Sports. 12 (2). https://doi.org/10.3390/sports12020050
Developing a selective culturing approach for Campylobacter hepaticus
Sakur, Sheaaz G. J., Williamson, Sarah L., Pavic, Anthony, Gao, Yuanshuo K., Harris, Taha, Kotiw, Michael, Muir, Wendy Isabelle and Groves, Peter John. 2024. "Developing a selective culturing approach for Campylobacter hepaticus." PLoS One. 19 (5). https://doi.org/10.1371/journal.pone.0302861
Descriptive epidemiology of Spotty Liver Disease in Australian cage-free brown egg layer chicken flocks with a scratch area
Groves, Peter J., Gao, Yuanshuo K., Kotiw, Michael, Eastwood, Sarah, Van, T. T. Hao Van, Moore, Robert J. and Muir, Wendy I.. 2024. "Descriptive epidemiology of Spotty Liver Disease in Australian cage-free brown egg layer chicken flocks with a scratch area." Poultry Science. 103 (8). https://doi.org/10.1016/j.psj.2024.103941
Chimeric hepatitis B surface antigen virus-like particles expressing the strep A epitope p*17 elicit a humoral immune response in mice
Dooley, Leanne, Ahmad, Tarek, Ozberk, Victoria, Pandey, Manisha, Good, Michael and Kotiw, Mkie. 2024. "Chimeric hepatitis B surface antigen virus-like particles expressing the strep A epitope p*17 elicit a humoral immune response in mice ." Heliyon. 10 (9). https://doi.org/10.1016/j.heliyon.2024.e30606
Feeling the Stress: Salivary Cortisol Responses of Softball Umpires during National Championships
Houison, Ronald J, Lamont-Mills, Andrea, Kotiw, Michael and Terry, Peter C.. 2024. "Feeling the Stress: Salivary Cortisol Responses of Softball Umpires during National Championships." Sports. 12 (5). https://doi.org/10.3390/sports12050128
Identification of epidemiological risk factors for spotty liver disease in cage-free layer flocks in houses with fully slatted flooring in Australia
Gao, Yuanshuo K., Singh, Mini, Muir, Wendy I., Kotiw, Michael and Groves, Peter J.. 2023. "Identification of epidemiological risk factors for spotty liver disease in cage-free layer flocks in houses with fully slatted flooring in Australia." Poultry Science. 102 (12). https://doi.org/10.1016/j.psj.2023.103139
Scratch area as an epidemiological risk factor for Spotty Liver Disease in cage-free layers in Australia
Gao, Yuanshuo K., Singh, Mini, Muir, Wendy I., Kotiw, Michael and Groves, Peter J.. 2023. "Scratch area as an epidemiological risk factor for Spotty Liver Disease in cage-free layers in Australia." Poultry Science. 102 (10). https://doi.org/10.1016/j.psj.2023.102922
Detection, characterization, and persistence of Campylobacter hepaticus, the cause of spotty liver disease in layer hens
Courtice, Jodi M., Ahmad, Tarek B., Wei, Chuanyu, Mahdi, Layla K., Palmieri, Chiara, Juma, Sarah, Groves, Peter J., Hancock, Kerry, Korolik, Victoria, Petrovsky, Nikolai and Kotiw, Michael. 2023. "Detection, characterization, and persistence of Campylobacter hepaticus, the cause of spotty liver disease in layer hens." Poultry Science. 102 (7). https://doi.org/10.1016/j.psj.2022.102462
Spotty Liver Disease: A South East Queensland Perspective and Research Progress
Kotiw, Michael and Courtice, Jodi. 2018. "Spotty Liver Disease: A South East Queensland Perspective and Research Progress." Poultry Information Exchange and Australasian Milling Conference (PIX/AMC 2018). Gold Coast, Australia 03 - 05 Jun 2018
Field Trials of a Spotty Liver Disease Vaccine: Vaccine Trial 1: Small scale Trial
Courtice, Jodi M., Ahmad, Tarek B., Wei, Chuanyu, Groves, Peter J., Gao, Karen, Phoon, Olivia C., Palmieri, Chiara, Petrovsky, Nikolai and Kotiw, Michael. 2020. "Field Trials of a Spotty Liver Disease Vaccine: Vaccine Trial 1: Small scale Trial." 2020 Australasian Veterinary Poultry Association (AVPA) Annual Scientific Meeting. Online 20 - 21 May 2020
Progress in the pathobiology and genetic epidemiology of Campylobacter hepaticus, the aetiological agent of Spotty Liver Disease
Kotiw, M., Courtice, J., Mahdi, L., Wei, C., Ahmad, T., Hancock, K. and Groves, P.. 2019. "Progress in the pathobiology and genetic epidemiology of Campylobacter hepaticus, the aetiological agent of Spotty Liver Disease." 2019 Australasian Veterinary Poultry Association (AVPA) Annual Scientific Meeting. Sydney, Australia 20 - 21 Feb 2019
Spotty Liver Disease: A review of an ongoing challenge in commercial free-range egg production
Courtice, Jodi Maree, Mahdi, Layla Khalid, Groves, Peter John and Kotiw, Michael. 2018. "Spotty Liver Disease: A review of an ongoing challenge in commercial free-range egg production." Veterinary Microbiology. 227, pp. 112-118. https://doi.org/10.1016/j.vetmic.2018.08.004
Spotty Liver Disease and Risk Factors
Gao, Yuanshou Karen, Singh, Mini, Muir, Wendy, Williamson, Sarah, Sharpe, Sue, Kotiw, Mike and Groves, Peter. 2021. "Spotty Liver Disease and Risk Factors." 2021 Australasian Veterinary Poultry Association (AVPA) Annual Scientific Meeting. Online 11 - 12 Feb 2021
Rheumatic heart disease: A review of the current status of global research activity
Dooley, Leanne M., Ahmad, Tarek B., Pandey, Manisha, Good, Micheal F. and Kotiw, Michael. 2021. "Rheumatic heart disease: A review of the current status of global research activity." Autoimmunity Reviews. 20 (2), pp. 1-23. https://doi.org/10.1016/j.autrev.2020.102740
Viral vs bacterial vectors for vaccine delivery
Kotiw, Michael. 2011. "Viral vs bacterial vectors for vaccine delivery." Mei, Xiaodan (ed.) 3rd Annual World Vaccine Congress: The Future of Global Vaccines (WCV 2011). Beijing, China 23 - 25 Mar 2011 Dalian, China.
Correlation between fatty acid profile and anti-inflammatory activity in common Australian sea-food by-products
Ahmad, Tarek B., Rudd, David, Kotiw, Michael, Liu, Lei and Benkendorff, Kirsten. 2019. "Correlation between fatty acid profile and anti-inflammatory activity in common Australian sea-food by-products." Marine Drugs. 17 (3), pp. 1-20. https://doi.org/10.3390/md17030155
Review of anti-inflammatory, immune-modulatory and wound healing properties of molluscs
Ahmad, Tarek B., Liu, Lei, Kotiw, Michael and Benkendorff, Kirsten. 2018. "Review of anti-inflammatory, immune-modulatory and wound healing properties of molluscs." Journal of Ethnopharmacology. 210, pp. 156-178. https://doi.org/10.1016/j.jep.2017.08.008
Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury
Ahmad, Tarek B., Rudd, David, Benkendorff, Kirsten, Mahdi, Layla K., Pratt, Kayla-Ann, Dooley, Leanne, Wei, Chuanyu and Kotiw, Michael. 2017. "Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury." PLoS One. 12 (10). https://doi.org/10.1371/journal.pone.0186904
Anti-inflammatory activity and structure-activity relationships of brominated indoles from a marine mollusc
Ahmad, Tarek B., Rudd, David, Smith, Joshua, Kotiw, Michael, Mouatt, Peter, Seymour, Lisa M., Liu, Lei and Benkendorff, Kirsten. 2017. "Anti-inflammatory activity and structure-activity relationships of brominated indoles from a marine mollusc." Marine Drugs. 15 (5), pp. 1-19. https://doi.org/10.3390/md15050133
Evasion of the toxic effects of oxygen
Hazell, Stuart L., Harris, Andrew G. and Trend, Mark A.. 2001. "Evasion of the toxic effects of oxygen." Mobley, Harry L. T., Mendz, George L. and Hazell, Stuart L. (ed.) Helicobacter pylori: physiology and genetics. United States. American Society for Microbiology. pp. 167-178
A screening method for the detection of fungi with potentially antimicrobial secondary metabolites
Boddington, Morwenna, Kotiw, Michael and Dearnaley, John. 2008. "A screening method for the detection of fungi with potentially antimicrobial secondary metabolites." ASM 2008: Changing Times. Melbourne, Australia 06 - 10 Jul 2008 Melbourne, Australia.
The diversity and antimicrobial activity of Preussia sp. Endophytes isolated from Australian dry rainforests
Mapperson, Rachel R., Kotiw, Michael, Davis, Rohan A. and Dearnaley, John D. W.. 2014. "The diversity and antimicrobial activity of Preussia sp. Endophytes isolated from Australian dry rainforests." Current Microbiology: an international journal. 68 (1), pp. 30-37. https://doi.org/10.1007/s00284-013-0415-5
GC-MS analysis and antimicrobial activity of the essential oil of the trunk exudates from pistacia atlantica kurdica
Sharifi, Mohammad Sharif and Hazell, Stuart Loyd. 2011. "GC-MS analysis and antimicrobial activity of the essential oil of the trunk exudates from pistacia atlantica kurdica ." Journal of Pharmaceutical Sciences and Research. 3 (8), pp. 1364-1367.
Genomics and drug discovery
Hazell, Stuart L.. 2002. "Genomics and drug discovery." Microbiology Australia. 23 (5), pp. 17-18.
Parenteral immunization of mice with a genetically inactivated pertussis toxin DNA vaccine induces cell-mediated immunity and protection
Fry, Scott R., Chen, Austen Y., Daggard, Grant and Mukkur, Trilochan K. S.. 2008. "Parenteral immunization of mice with a genetically inactivated pertussis toxin DNA vaccine induces cell-mediated immunity and protection." Journal of Medical Microbiology. 57 (1), pp. 28-35. https://doi.org/10.1099/jmm.0.47527-0
Evaluation of immune response to recombinant potential protective antigens of Mycoplasma hyopneumoniae delivered as cocktail DNA and/or recombinant protein vaccines in mice
Chen, Austen Y., Fry, Scott R., Daggard, Grant E. and Mukkur, Trilochan K. S.. 2008. "Evaluation of immune response to recombinant potential protective antigens of Mycoplasma hyopneumoniae delivered as cocktail DNA and/or recombinant protein vaccines in mice." Vaccine. 26 (34), pp. 4372-4378. https://doi.org/10.1016/j.vaccine.2008.06.005
Comparative immunogenicity of M. hyopneumoniae NrdF encoded in different expression systems delivered orally via attenuated S. typhimurium aroA in mice
Chen, Austen Y., Fry, Scott Robert, Forbes-Faulkner, Judy, Daggard, Grant and Mukkur, T. K. S.. 2006. "Comparative immunogenicity of M. hyopneumoniae NrdF encoded in different expression systems delivered orally via attenuated S. typhimurium aroA in mice." Veterinary Microbiology. 114 (3-4), pp. 252-259. https://doi.org/10.1016/j.vetmic.2005.12.009
The development and evaluation of DNA vaccines against whooping cough using a murine respiratory model of infection
Fry, Scott Robert. 2006. The development and evaluation of DNA vaccines against whooping cough using a murine respiratory model of infection. PhD Thesis Doctor of Philosophy. University of Southern Queensland.
Ravenic acid, a new tetramic acid isolated from a cultured microfungus, penicillium sp.
Michael, Adam P., Grace, Emily J., Kotiw, Mike and Barrow, Russell A.. 2002. "Ravenic acid, a new tetramic acid isolated from a cultured microfungus, penicillium sp." Journal of Natural Products. 65 (9), pp. 1360-1362. https://doi.org/10.1021/np0200358
Xanthones from a microfungus of the genus Xylaria
Healy, Peter C., Hocking, Ailsa, Tran-Dinh, Nai, Pitt, John I., Shivas, Roger G., Mitchell, Jennifer K., Kotiw, Mike and Davis, Rohan A.. 2004. "Xanthones from a microfungus of the genus Xylaria." Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology. 65 (16), pp. 2373-2378. https://doi.org/10.1016/j.phytochem.2004.07.019
Phomoxins B and C: polyketides from an endophytic fungus of the genus eupenicillium
Davis, Rohan A., Andjic, Vesna, Kotiw, Michael and Shivas, Roger G.. 2005. "Phomoxins B and C: polyketides from an endophytic fungus of the genus eupenicillium." Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology. 66 (23), pp. 2771-2775. https://doi.org/10.1016/j.phytochem.2005.09.004
A RAPD-PCR genotyping assay which correlates with serotypes of group B streptococci
Zhang, G. W., Kotiw, M. and Daggard, G.. 2002. "A RAPD-PCR genotyping assay which correlates with serotypes of group B streptococci." Letters in Applied Microbiology. 35 (3), pp. 247-250. https://doi.org/10.1046/j.1472-765X.2002.01177.x
Late-onset and recurrent neonatal group B streptococcal disease associated with breast milk transmission
Kotiw, Michael, Zhang, Gwang W., Daggard, Grant, Reiss-Levy, Elizabeth, Tapsall, John W. and Numa, Andrew. 2003. "Late-onset and recurrent neonatal group B streptococcal disease associated with breast milk transmission." Pediatric and Developmental Pathology. 6 (3), pp. 251-256. https://doi.org/10.1007/s10024-001-0276-y
Evaluation of the immunogenicity of the P97R1 adhesin of Mycoplasma hyopneumoniae as a mucosal vaccine in mice
Chen, Austen Y., Fry, Scott R., Forbes-Faulkner, Judy, Daggard, Grant and Mukkur, T. K. S.. 2006. "Evaluation of the immunogenicity of the P97R1 adhesin of Mycoplasma hyopneumoniae as a mucosal vaccine in mice." Journal of Medical Microbiology. 55 (7), pp. 923-929. https://doi.org/10.1099/jmm.0.46088-0
Synthesis of the fungal natural product (-)-xylariamide A
Kotiw, Michael and Davis, Rohan A.. 2005. "Synthesis of the fungal natural product (-)-xylariamide A." Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry. 46 (31), pp. 5199-5201. https://doi.org/10.1016/j.tetlet.2005.05.114
Caelestines A-D, Brominated Quinolinecarboxylic Acids from the Australian Ascidian Aplidium caelestis
Yin, Sheng, Boyle, Glen M., Carroll, Anthony R., Kotiw, Michael, Dearnaley, John, Quinn, Ronald J. and Davis, Rohan A.. 2010. "Caelestines A-D, Brominated Quinolinecarboxylic Acids from the Australian Ascidian Aplidium caelestis." Journal of Natural Products. 73 (9), pp. 1586-1589. https://doi.org/10.1021/np100329w
Detection of anti-TNFα activity in canine hyperimmune serum using a TNFα inhibition assay
Kotiw, Michael, Morgan, Michael, Taylor, Stephen M. and Shiels, Ian A.. 2010. "Detection of anti-TNFα activity in canine hyperimmune serum using a TNFα inhibition assay ." Veterinary Clinical Pathology. 39 (1), pp. 46-52. https://doi.org/10.1111/j.1939-165X.2009.00166.x
Anti-inflammatory activity of hyperimmune plasma in a lipopolysaccharide-mediated rat air pouch model of inflammation
Essien, Bryan E. and Kotiw, Michael. 2012. "Anti-inflammatory activity of hyperimmune plasma in a lipopolysaccharide-mediated rat air pouch model of inflammation." Inflammation. 35 (1), pp. 58-64. https://doi.org/10.1007/s10753-010-9289-x
Strategies for the enrichment and identification of basic proteins in proteome projects
Bae, Soo-Han, Harris, Andrew G., Hains, Peter G., Chen, Hong, Garfin, David E., Hazell, Stuart L., Paik, Young-Ki, Walsh, Bradley J. and Cordwell, Stuart J.. 2003. "Strategies for the enrichment and identification of basic proteins in proteome projects." Proteomics. 3 (5), pp. 569-579. https://doi.org/10.1002/pmic.200300392
Catalase (KatA) and KatA-associated protein (KapA) are essential to persistent colonization in the Helicobacter pylori SS1 mouse model
Harris, Andrew G., Wilson, John E., Danon, Stephen J., Dixon, Michael F., Donegan, Kevin and Hazell, Stuart L.. 2003. "Catalase (KatA) and KatA-associated protein (KapA) are essential to persistent colonization in the Helicobacter pylori SS1 mouse model." Microbiology. 149 (3), pp. 665-672. https://doi.org/10.1099/mic.0.26012-0
Effect of canine hyperimmune plasma on TNFa and inflammatory cell levels in a lipopolysaccharide-mediated rat air pouch model of inflammation
Strunin, Dmitry, Essien, Bryan, Kotiw, Michael and Butler, Harry. 2009. "Effect of canine hyperimmune plasma on TNFa and inflammatory cell levels in a lipopolysaccharide-mediated rat air pouch model of inflammation." Reinhart, Konrad (ed.) Sepsis 2009: Critical Care Conference. Amsterdam, Netherlands 11 - 14 Nov 2009 https://doi.org/10.1186/cc8064
A mathematical model to account for quantitative iterative effect of TNF-α positive feedback mechanism on inflammatory cascade in TLR-4 mediated TNF-α signaling pathway
Roberts, Tony, Essien, Bryan, Kotiw, Michael, Butler, Harry and Strunin, Dmitry. 2008. "A mathematical model to account for quantitative iterative effect of TNF-α positive feedback mechanism on inflammatory cascade in TLR-4 mediated TNF-α signaling pathway." Ragan, Mark (ed.) 19th International Conference on Genome Informatics (GIW 2008). Gold Coast, Australia 01 - 03 Dec 2008 London, United Kingdom.
In vitro effect of canine hyperimmune sera on TNFa activity
Kotiw, Michael, Shiels, I. A., Wilson, R. P. and Reeve-Johnson, Lloyd. 2006. "In vitro effect of canine hyperimmune sera on TNFa activity." Journal of Veterinary Pharmacology and Therapeutics. 29 (Supplement 1), pp. 100-101. https://doi.org/10.1111/j.1365-2885.2006.00761.x
Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide
Xu, Youhong, Chen, Austen Y., Fry, Scott R., Barrow, Russell A., Marshall, Raymond L. and Mukkur, T. K. S.. 2007. "Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide." International Immunopharmacology. 7 (4), pp. 515-523. https://doi.org/10.1016/j.intimp.2006.12.008
The effect of equine hyperimmune sera on TNF alpha activity in a L929 cell bioassay
Kotiw, M., Raghaven, C., Johnson, M., Shiels, I. A. and Wilson, R. P.. 2006. "The effect of equine hyperimmune sera on TNF alpha activity in a L929 cell bioassay." Bryden, W. L. (ed.) AESS 2006: Australian Equine Science Symposium: Research for the 21st Century Horse Industry: From Genomics to the Winning Post. Gold Coast, Australia 13 - 14 Jun 2006 Gold Coast, Australia.
Biological methods: a novel course in undergraduate biology
Kotiw, Michael, Learmonth, Robert P. and Sutherland, Mark W.. 1999. "Biological methods: a novel course in undergraduate biology." Biochemical Education. 27 (3), pp. 131-134. https://doi.org/10.1016/S0307-4412(99)00002-3
The relevance of human rights to health status in Australian Aboriginal and Torres Strait Islander communities
Smallwood, Gracelyn, White, Colin and Kotiw, Michael. 1997. "The relevance of human rights to health status in Australian Aboriginal and Torres Strait Islander communities." Health and Human Rights: an international journal. 2 (2), pp. 127-136.
In vitro and in vivo determination of ant-TNFa activity in canine plasma from donors subject to pre conditioning with endotoxin
Kotiw, Michael, Morgan, Michael, Lopez, Jesus, Taylor, Steven and Shiels, Ian. 2007. "In vitro and in vivo determination of ant-TNFa activity in canine plasma from donors subject to pre conditioning with endotoxin." Marshall, John (ed.) SEPSIS 2007: International Sepsis Forum ISF . Paris, France 26 - 29 Sep 2007 London, United Kingdom. https://doi.org/10.1186/cc6002
In the footsteps of Florey: utilising cultured microfungi in the search for new antibiotics
Parker, C., Barrow, Russell, Bloor, S. J., Grace, Emily J., Michael, Adam P., Thompson, Christopher and Kotiw, Michael. 2001. "In the footsteps of Florey: utilising cultured microfungi in the search for new antibiotics." Bernhardt, Debra (ed.) FACS 2001: 9th Asian Chemical Congress . Brisbane, Australia 02 - 04 Jul 2001 Brisbane, Australia.
Antibiotic susceptibility and resistance
Glupczynski, Youri, Megraud, Francis and Hazell, Stuart. 2001. "Antibiotic susceptibility and resistance." Mobley, Harry L. T., Mendz, George L. and Hazell, Stuart L. (ed.) Helicobacter pylori: physiology and genetics. Washington, DC. United States. American Society for Microbiology. pp. 511-532
Exploring the potential for dual vaccination against Hepatitis B virus and Helicobacter pylori using a recombinant virus like particle
Kotiw, Michael, Olive, C., Johnson, Megan, Pandy, M., Fry, Scott Robert, Hazell, Stuart L., Netter, H. and Good, M.. 2006. "Exploring the potential for dual vaccination against Hepatitis B virus and Helicobacter pylori using a recombinant virus like particle." Sirtori, Patrizia (ed.) 6th National Congress of the Italian Society of Virology - a joint meeting with the Virus Group of the Society for General Microbiology (UK). Orvieto, Italy 18 - 20 Sep 2006 Italy.
A metabolite-deficient mutant of Bordetella pertussis that induces secretory IgA and cell-mediated immunity in mice vaccinated by the intranasal route
Mukkur, T. K. S., Cornford-Nairn, Renee A., Rossetti, T., Kershaw, S., Fry, Scott Robert, Xu, Youhong and Daggard, Grant A.. 2005. "A metabolite-deficient mutant of Bordetella pertussis that induces secretory IgA and cell-mediated immunity in mice vaccinated by the intranasal route." Fang, Ferric C. (ed.) 105th American Society for Microbiology: General Meeting. Atlanta, Georgia 05 - 09 Jun 2005 Washington.
Isochromophilone IX, a novel GABA-containing metabolite isolated from a cultured fungus, Penicillium sp.
Michael, Adam P., Grace, Emily J., Kotiw, Michael and Barrow, Russell A.. 2003. "Isochromophilone IX, a novel GABA-containing metabolite isolated from a cultured fungus, Penicillium sp." Australian Journal of Chemistry: an international journal for chemical science. 56 (1), pp. 13-15. https://doi.org/10.1071/CH02021