Correlation between fatty acid profile and anti-inflammatory activity in common Australian sea-food by-products

Article

Ahmad, Tarek B., Rudd, David, Kotiw, Michael, Liu, Lei and Benkendorff, Kirsten. 2019. "Correlation between fatty acid profile and anti-inflammatory activity in common Australian sea-food by-products." Marine Drugs. 17 (3), pp. 1-20. https://doi.org/10.3390/md17030155
Article Title

Correlation between fatty acid profile and anti-inflammatory activity in common Australian sea-food by-products

ERA Journal ID14994
Article CategoryArticle
AuthorsAhmad, Tarek B. (Author), Rudd, David (Author), Kotiw, Michael (Author), Liu, Lei (Author) and Benkendorff, Kirsten (Author)
Journal TitleMarine Drugs
Journal Citation17 (3), pp. 1-20
Article Number155
Number of Pages20
Year2019
Place of PublicationSwitzerland
ISSN1660-3397
Digital Object Identifier (DOI)https://doi.org/10.3390/md17030155
Web Address (URL)https://www.mdpi.com/1660-3397/17/3/155
Abstract

Marine organisms are a rich source of biologically active lipids with anti-inflammatory activities. These lipids may be enriched in visceral organs that are waste products from common seafood. Gas chromatography-mass spectrometry and fatty acid methyl ester (FAME) analyses were performed to compare the fatty acid compositions of lipid extracts from some common seafood organisms, including octopus (Octopus tetricus), squid (Sepioteuthis australis), Australian sardine (Sardinops sagax), salmon (Salmo salar) and school prawns (Penaeus plebejus). The lipid extracts were tested for anti-inflammatory activity by assessing their inhibition of nitric oxide (NO) and tumor necrosis factor alpha (TNFα) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 mouse cells. The lipid extract from both the flesh and waste tissue all contained high amounts of polyunsaturated fatty acids (PUFAs) and significantly inhibited NO and TNFα production. Lipid extracts from the cephalopod mollusks S. australis and O. tetricus demonstrated the highest total PUFA content, the highest level of omega 3 (ω-3) PUFAs, and the highest anti-inflammatory activity. However, multivariate analysis indicates the complex mixture of saturated, monounsaturated, and polyunsaturated fatty acids may all influence the anti-inflammatory activity of marine lipid extracts. This study confirms that discarded parts of commonly consumed seafood species provide promising sources for the development of new potential anti-inflammatory nutraceuticals.

Keywordsseafood waste; polyunsaturated fatty acid; NO inhibition; fish oil; marine nutraceuticals
ANZSRC Field of Research 2020420899. Traditional, complementary and integrative medicine not elsewhere classified
Byline AffiliationsSouthern Cross University
Division of Research and Innovation
Institution of OriginUniversity of Southern Queensland
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Kotiw, M., Raghaven, C., Johnson, M., Shiels, I. A. and Wilson, R. P.. 2006. "The effect of equine hyperimmune sera on TNF alpha activity in a L929 cell bioassay." Bryden, W. L. (ed.) AESS 2006: Australian Equine Science Symposium: Research for the 21st Century Horse Industry: From Genomics to the Winning Post. Gold Coast, Australia 13 - 14 Jun 2006 Gold Coast, Australia.
Biological methods: a novel course in undergraduate biology
Kotiw, Michael, Learmonth, Robert P. and Sutherland, Mark W.. 1999. "Biological methods: a novel course in undergraduate biology." Biochemical Education. 27 (3), pp. 131-134. https://doi.org/10.1016/S0307-4412(99)00002-3
The relevance of human rights to health status in Australian Aboriginal and Torres Strait Islander communities
Smallwood, Gracelyn, White, Colin and Kotiw, Michael. 1997. "The relevance of human rights to health status in Australian Aboriginal and Torres Strait Islander communities." Health and Human Rights: an international journal. 2 (2), pp. 127-136.
In vitro and in vivo determination of ant-TNFa activity in canine plasma from donors subject to pre conditioning with endotoxin
Kotiw, Michael, Morgan, Michael, Lopez, Jesus, Taylor, Steven and Shiels, Ian. 2007. "In vitro and in vivo determination of ant-TNFa activity in canine plasma from donors subject to pre conditioning with endotoxin." Marshall, John (ed.) SEPSIS 2007: International Sepsis Forum ISF . Paris, France 26 - 29 Sep 2007 London, United Kingdom. https://doi.org/10.1186/cc6002
In the footsteps of Florey: utilising cultured microfungi in the search for new antibiotics
Parker, C., Barrow, Russell, Bloor, S. J., Grace, Emily J., Michael, Adam P., Thompson, Christopher and Kotiw, Michael. 2001. "In the footsteps of Florey: utilising cultured microfungi in the search for new antibiotics." Bernhardt, Debra (ed.) FACS 2001: 9th Asian Chemical Congress . Brisbane, Australia 02 - 04 Jul 2001 Brisbane, Australia.
Exploring the potential for dual vaccination against Hepatitis B virus and Helicobacter pylori using a recombinant virus like particle
Kotiw, Michael, Olive, C., Johnson, Megan, Pandy, M., Fry, Scott Robert, Hazell, Stuart L., Netter, H. and Good, M.. 2006. "Exploring the potential for dual vaccination against Hepatitis B virus and Helicobacter pylori using a recombinant virus like particle." Sirtori, Patrizia (ed.) 6th National Congress of the Italian Society of Virology - a joint meeting with the Virus Group of the Society for General Microbiology (UK). Orvieto, Italy 18 - 20 Sep 2006 Italy.
Isochromophilone IX, a novel GABA-containing metabolite isolated from a cultured fungus, Penicillium sp.
Michael, Adam P., Grace, Emily J., Kotiw, Michael and Barrow, Russell A.. 2003. "Isochromophilone IX, a novel GABA-containing metabolite isolated from a cultured fungus, Penicillium sp." Australian Journal of Chemistry: an international journal for chemical science. 56 (1), pp. 13-15. https://doi.org/10.1071/CH02021