Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury
Article
Article Title | Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury |
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ERA Journal ID | 39745 |
Article Category | Article |
Authors | Ahmad, Tarek B. (Author), Rudd, David (Author), Benkendorff, Kirsten (Author), Mahdi, Layla K. (Author), Pratt, Kayla-Ann (Author), Dooley, Leanne (Author), Wei, Chuanyu (Author) and Kotiw, Michael (Author) |
Journal Title | PLoS One |
Journal Citation | 12 (10) |
Number of Pages | 18 |
Year | 2017 |
Publisher | Public Library of Science (PLoS) |
Place of Publication | United States |
ISSN | 1932-6203 |
Digital Object Identifier (DOI) | https://doi.org/10.1371/journal.pone.0186904 |
Web Address (URL) | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186904 |
Abstract | New drug leads for the treatment of inflammation are urgently needed. Marine molluscs are widely used as traditional medicines for the treatment of inflammation. Here we report the positive effects of a hypobranchial gland (HBG) extract and the dominant bioactive compound 6-bromoisatin from the Muricidae mollusc Dicathais orbita, for reducing lipopolysaccharide (LPS) induced acute lung inflammation in a mouse model. Both 6-bromoisatin and the HBG extract suppressed the inflammatory response in mice that were pre-treated byoral gavage at 48, 24 and 1 h prior to LPS infusion. The inflammatory antagonists weretested at concentrations of 0.5 mg/g and 0.1 mg/g HBG extract and 0.1 mg/g and 0.05 mg/g 6-bromoisatin in carrier oil and all treatments reduced inflammation as indicated by a significant suppression of inflammatory markers present in bronchoalveolar lavage fluid (BALF), in comparison to LPS induced positive control mice administered the carrier oil alone (p <0.0001). Tumour necrosis factor-alpha (TNFα) and interleukin-1 beta (IL-1β) levels, in addition to total protein concentration were all significantly reduced in BALF from mice treated with the extract or 6-bromoisatin. Furthermore, all treatment groups showed significant |
Keywords | brominated indoles, 6-bromoisitin inflammation muricidae molluscs |
ANZSRC Field of Research 2020 | 420899. Traditional, complementary and integrative medicine not elsewhere classified |
Byline Affiliations | Southern Cross University |
Centre for Health Sciences Research | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q48x1/brominated-indoles-from-a-marine-mollusc-inhibit-inflammation-in-a-murine-model-of-acute-lung-injury
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