Association of Helicobacter pylori with colorectal cancer development

Article

Alsamak, Fadi Fouad, Abdulamir, Ahmed Sahib, Mahdi, Layla Khalid, Alnaib, Khalid and Abu Bakar, Fatimah. 2010. "Association of Helicobacter pylori with colorectal cancer development." Asian Biomedicine. 4 (4), pp. 609-618.

Article Title	Association of Helicobacter pylori with colorectal cancer development
Article Category	Article
Authors	Alsamak, Fadi Fouad (Author), Abdulamir, Ahmed Sahib (Author), Mahdi, Layla Khalid (Author), Alnaib, Khalid (Author) and Abu Bakar, Fatimah (Author)
Journal Title	Asian Biomedicine
Journal Citation	4 (4), pp. 609-618
Number of Pages	9
Year	2010
Place of Publication	Thailand
Web Address (URL)	http://abm.digitaljournals.org/index.php/abm/article/viewFile/555/410
Abstract	Background: Helicobacter pylori (H. pylori) may be associated with colorectal cancer. However, the underlying mechanisms are still unclear. Objectives: Explore the serostatus of H. pylori cytotoxicity-associated gene A product (CagA) in patients with colorectal carcinoma, and assess the association of H. pylori with colorectal cancer via c-Myc and MUC-2 proteins at tumor tissues. Methods: H. pylori CagA IgG antibodies were screened using enzyme-linked immunosorbent assay (ELISA) in 30 patients with colorectal carcinoma and 30 cancer-free control subjects. Paraffin-embedded blocks were examined for the expression of c-Myc and MUC-2 protein by immunohistochemistry. Results: H. pylori CagA seropositivity increased significantly among colorectal cancer patients (p <0.05). The expression of c-Myc and MUC-2 in colorectal carcinoma patients was over-expressed (80%), and downexpressed (63%) in resection margins (p <0.05). c-Myc over-expression and MUC-2 down-expression were associated with CagA-positive rather than CagA-negative H. pylori patients. In 16 CagA seropositive vs. 14 CagA seronegative patients, the expression rate was 97.3% vs. 64.2% and 33.3% vs. 78.5% for cMyc and MUC-2, respectively. CagA IgG level was significantly higher in positive than in negative c-Myc patients (p= 0.036), and in negative than in positive MUC-2 patients (p= 0.044). c-Myc and MUC-2 were positively and inversely correlated with CagA IgG level (p <0.05). Conclusions: CagA-seropositive H. pylori is most probably associated with colorectal cancer development. Part of the underlying mechanism for such association might be via alterations in expression of MUC-2, which depletes the mucous protective layer in the colo-rectum, and c-Myc, which stimulates the growth of cancerous cells.
Keywords	Helicobacter pylori, colorectal cancer, Cag-A, MUC-2
ANZSRC Field of Research 2020	310701. Bacteriology
	320701. Medical bacteriology
Public Notes	File reproduced in accordance with the copyright policy of the publisher/author.
Byline Affiliations	Al-Nahrain University, Iraq
	University of Adelaide
	University of Putra Malaysia, Malaysia
Institution of Origin	University of Southern Queensland

Permalink -

https://research.usq.edu.au/item/q35x6/association-of-helicobacter-pylori-with-colorectal-cancer-development

597
total views
7
total downloads
1
views this month
0
downloads this month

Export as

Related outputs

Correction: Alhamami et al. First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia. Microorganisms 2021, 9, 1322

Alhamami, Tamara, Chowdhury, Piklu Roy, Gomes, Nancy, Carr, Mandi, Veltman, Tania, Khazandi, Manouchehr, Mollinger, Joanne, Deutscher, Ania T., Turni, Conny, Mahdi, Layla, Venter, Henrietta, Abraham, Sam, Djordjevic, Steven P. and Trott, D.. 2022. "Correction: Alhamami et al. First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia. Microorganisms 2021, 9, 1322." Microorganisms. 10 (4), pp. 1-2. https://doi.org/10.3390/microorganisms10040825

A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections

Blaskovich, Mark A. T., Hansford, Karl A., Butler, Mark S., Ramu, Soumya, Kavanagh, Angela M., Jarrad, Angie M., Prasetyoputri, Anggia, Pitt, Miranda E., Huang, J. X., Lindahl F., Ziora Z.M., Bradford T., Muldoon C., Rajaratnam P., Pelingon R., Edwards D.J., Zhang B., Amado M., Elliott A.G., ..., Cooper M.A.. 2022. "A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections." Science Translational Medicine. 14 (662), pp. 1-16. https://doi.org/10.1126/scitranslmed.abj2381

Progress in the pathobiology and genetic epidemiology of Campylobacter hepaticus, the aetiological agent of Spotty Liver Disease

Kotiw, M., Courtice, J., Mahdi, L., Wei, C., Ahmad, T., Hancock, K. and Groves, P.. 2019. "Progress in the pathobiology and genetic epidemiology of Campylobacter hepaticus, the aetiological agent of Spotty Liver Disease." 2019 Australasian Veterinary Poultry Association (AVPA) Annual Scientific Meeting. Sydney, Australia 20 - 21 Feb 2019

Spotty Liver Disease: A review of an ongoing challenge in commercial free-range egg production

Courtice, Jodi Maree, Mahdi, Layla Khalid, Groves, Peter John and Kotiw, Michael. 2018. "Spotty Liver Disease: A review of an ongoing challenge in commercial free-range egg production." Veterinary Microbiology. 227, pp. 112-118. https://doi.org/10.1016/j.vetmic.2018.08.004

First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia

Alhamami, Tamara, Chowdhury, Piklu Roy, Gomes, Nancy, Carr, Mandi, Veltman, Tania, Khazandi, Manouchehr, Mollinger, Joanne, Deutscher, Ania T., Turni, Conny, Mahdi, Layla, Venter, Henrietta, Abraham, Sam, Djordjevic, Steven P. and Trott, Darren J.. 2021. "First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia." Microorganisms. 9 (6), pp. 1-17. https://doi.org/10.3390/microorganisms9061322

Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury

Ahmad, Tarek B., Rudd, David, Benkendorff, Kirsten, Mahdi, Layla K., Pratt, Kayla-Ann, Dooley, Leanne, Wei, Chuanyu and Kotiw, Michael. 2017. "Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury." PLoS One. 12 (10). https://doi.org/10.1371/journal.pone.0186904

The pneumococcal alpha-glycerophosphate oxidase enhances nasopharyngeal colonization through binding to host glycoconjugates

Mahdi, Layla K., Higgins, Melanie A., Day, Christopher J., Tiralongo, Joe, Hartley-Tassell, Lauren E., Jennings, Michael P., Gordon, David L., Paton, Adrienne W., Paton, James C. and Ogunniyi, Abiodun D.. 2017. "The pneumococcal alpha-glycerophosphate oxidase enhances nasopharyngeal colonization through binding to host glycoconjugates." EBioMedicine. 18, pp. 236-243. https://doi.org/10.1016/j.ebiom.2017.03.002

Application of RAPD- PCR to differentiate among Aeromonas spp

Jaladet, M. S. J., M., Layla Kh. and Zaineb, M. N.. 2004. "Application of RAPD- PCR to differentiate among Aeromonas spp ." Journal of Al-Nahrain University. 7, pp. 48-56.

Chemical characterization and anti-bacterial activity of black tea extract components

Mahdi, H. S., Mahdi, L. Kh. and Saour, K. Y.. 2005. "Chemical characterization and anti-bacterial activity of black tea extract components ." Journal of The Faculty of Medicine Baghdad. 47 (2), pp. 174-178.

Preparation of C-reactive protein latex reagent of human serum

Alshalchi, Sahar A., Mahdi, Layla K. and Sabar, Muna. 2006. "Preparation of C-reactive protein latex reagent of human serum ." Iraqi Journal of Biotechnology. 5 (1), pp. 112-122.

The variable region of the pneumococcal pathogenicity island 1 is responsible for the unusually high virulence of a serotype 1 isolate

Harvey, Richard M., Trappetti, Claudia, Mahdi, Layla K., Wang, Hui, McAllister, Lauren J., Scalvini, Alexandra, Paton, Adrienne W. and Paton, James C.. 2016. "The variable region of the pneumococcal pathogenicity island 1 is responsible for the unusually high virulence of a serotype 1 isolate." Infection and Immunity. 84 (3), pp. 822-832. https://doi.org/10.1128/IAI.01454-15

A functional genomics catalogue of activated transcription factors during pathogenesis of pneumococcal disease

Mahdi, Layla K., Deihim, Tahereh, Zamansani, Fatemeh, Fruzangohar, Mario, Adelson, David L., Paton, James C., Ogunniyi, Abiodun D. and Ebrahimie, Esmaeil. 2014. "A functional genomics catalogue of activated transcription factors during pathogenesis of pneumococcal disease." BMC Genomics. 15 (1), pp. 1-15. https://doi.org/10.1186/1471-2164-15-769

Comparative GO: a web application for comparative gene ontology and gene ontology-based gene selection in bacteria

Fruzangohar, Mario, Ebrahimie, Esmaeil, Ogunniyi, Abiodun D., Mahdi, Layla K., Paton, James C. and Adelson, David L.. 2013. "Comparative GO: a web application for comparative gene ontology and gene ontology-based gene selection in bacteria." PLoS One. 8 (3), pp. e58759-e58767. https://doi.org/10.1371/journal.pone.0058759

A transcription factor contributes to pathogenesis and virulence in Streptococcus pneumoniae

Mahdi, Layla K., Ebrahimie, Esmaeil, Adelson, David L., Paton, James C. and Ogunniyi, Abiodun D.. 2013. "A transcription factor contributes to pathogenesis and virulence in Streptococcus pneumoniae." PLoS One. 8 (8), pp. e70862-e70871. https://doi.org/10.1371/journal.pone.0070862

Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice

Mahdi, Layla K., Wang, Hui, Van der Hoek, Mark B., Paton, James C. and Ogunniyi, Abiodun D.. 2012. "Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice." Journal of Clinical Investigation. 122 (6), pp. 2208-2220. https://doi.org/10.1172/JCI45850

Identification of genes that contribute to the pathogenesis of invasive Pneumococcal Disease by In Vivo transcriptomic analysis

Ogunniyi, Abiodun D., Mahdi, Layla K., Trappetti, Claudia, Verhoeven, Nadine, Mermans, Daphne, Van der Hoek, Mark B., Plumptre, Charles D. and Paton, James C.. 2012. "Identification of genes that contribute to the pathogenesis of invasive Pneumococcal Disease by In Vivo transcriptomic analysis." Infection and Immunity. 80 (9), pp. 3268-3278. https://doi.org/10.1128/IAI.00295-12

Characterization of pneumococcal genes involved in bloodstream invasion in a mouse model

Mahdi, Layla K., Van der Hoek, Mark B., Ebrahimie, Esmaeil, Paton, James C. and Ogunniyi, Abiodun D.. 2015. "Characterization of pneumococcal genes involved in bloodstream invasion in a mouse model." PLoS One. 10 (11), pp. 1-15. https://doi.org/10.1371/journal.pone.0141816

Correction: Comparative GO: A Web Application for Comparative Gene Ontology and Gene Ontology-Based Gene Selection in Bacteria

Fruzangohar, Mario, Ebrahimie, Esmaeil, Ogunniyi, Abiodun D., Mahdi, Layla K., Paton, James C. and Adelson, David L.. 2015. "Correction: Comparative GO: A Web Application for Comparative Gene Ontology and Gene Ontology-Based Gene Selection in Bacteria." PLoS One. 10 (4). https://doi.org/10.1371/journal.pone.0125537

Central role of manganese in regulation of stress responses, physiology, and metabolism in streptococcus pneumoniae

Ogunniyi, Abiodun D., Mahdi, Layla K., Jennings, Michael P., McEwan, Alastair G., McDevitt, Christopher A., Van der Hoek, Mark B., Bagley, Christopher J., Hoffmann, Peter, Gould, Katherine A. and Paton, James C.. 2010. "Central role of manganese in regulation of stress responses, physiology, and metabolism in streptococcus pneumoniae." Journal of Bacteriology. 192 (17), pp. 4489-4497. https://doi.org/10.1128/JB.00064-10

Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenoma

Abdulamir, Ahmed S., Hafidh, Rand R., Mahdi, Layla K., Al-jeboori, Tarik and Abu bakar, Fatimah. 2009. "Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenoma." BMC Cancer. 9 (1), pp. 403-415. https://doi.org/10.1186/1471-2407-9-403

Pneumococcal histidine triad proteins are regulated by the Zn2+-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H

Ogunniyi, Abiodun D., Grabowicz, Marcin, Mahdi, Layla K., Cook, Jan, Gordon, David L., Sadlon, Tania A. and Paton, James C.. 2009. "Pneumococcal histidine triad proteins are regulated by the Zn2+-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H." The FASEB Journal. 23 (3), pp. 731-738. https://doi.org/10.1096/fj.08-119537

The interplay between p53 and p21 tumor suppressor proteins in the transformation of colorectal adenoma to carcinoma

Abdulamir, A. S., Hafidh, R. R., Mahdi, L. K., Al-jeboori, T. R., Abu bakar, F. and Abbas, K. A.. 2008. "The interplay between p53 and p21 tumor suppressor proteins in the transformation of colorectal adenoma to carcinoma." American Journal of Immunology. 4 (2), pp. 14-22. https://doi.org/10.3844/ajisp.2008.14.22

Pneumococcal virulence gene expression and host cytokine profiles during pathogenesis of invasive disease

Mahdi, Layla K., Ogunniyi, Abiodun D., LeMessurier, Kim S. and Paton, James C.. 2008. "Pneumococcal virulence gene expression and host cytokine profiles during pathogenesis of invasive disease ." Infection and Immunity. 76 (2), pp. 646-657. https://doi.org/10.1128/IAI.01161-07