Association of Helicobacter pylori with colorectal cancer development

Article

Alsamak, Fadi Fouad, Abdulamir, Ahmed Sahib, Mahdi, Layla Khalid, Alnaib, Khalid and Abu Bakar, Fatimah. 2010. "Association of Helicobacter pylori with colorectal cancer development." Asian Biomedicine. 4 (4), pp. 609-618.

Article Title	Association of Helicobacter pylori with colorectal cancer development
Article Category	Article
Authors	Alsamak, Fadi Fouad (Author), Abdulamir, Ahmed Sahib (Author), Mahdi, Layla Khalid (Author), Alnaib, Khalid (Author) and Abu Bakar, Fatimah (Author)
Journal Title	Asian Biomedicine
Journal Citation	4 (4), pp. 609-618
Number of Pages	9
Year	2010
Place of Publication	Thailand
Web Address (URL)	http://abm.digitaljournals.org/index.php/abm/article/viewFile/555/410
Abstract	Background: Helicobacter pylori (H. pylori) may be associated with colorectal cancer. However, the underlying mechanisms are still unclear. Objectives: Explore the serostatus of H. pylori cytotoxicity-associated gene A product (CagA) in patients with colorectal carcinoma, and assess the association of H. pylori with colorectal cancer via c-Myc and MUC-2 proteins at tumor tissues. Methods: H. pylori CagA IgG antibodies were screened using enzyme-linked immunosorbent assay (ELISA) in 30 patients with colorectal carcinoma and 30 cancer-free control subjects. Paraffin-embedded blocks were examined for the expression of c-Myc and MUC-2 protein by immunohistochemistry. Results: H. pylori CagA seropositivity increased significantly among colorectal cancer patients (p <0.05). The expression of c-Myc and MUC-2 in colorectal carcinoma patients was over-expressed (80%), and downexpressed (63%) in resection margins (p <0.05). c-Myc over-expression and MUC-2 down-expression were associated with CagA-positive rather than CagA-negative H. pylori patients. In 16 CagA seropositive vs. 14 CagA seronegative patients, the expression rate was 97.3% vs. 64.2% and 33.3% vs. 78.5% for cMyc and MUC-2, respectively. CagA IgG level was significantly higher in positive than in negative c-Myc patients (p= 0.036), and in negative than in positive MUC-2 patients (p= 0.044). c-Myc and MUC-2 were positively and inversely correlated with CagA IgG level (p <0.05). Conclusions: CagA-seropositive H. pylori is most probably associated with colorectal cancer development. Part of the underlying mechanism for such association might be via alterations in expression of MUC-2, which depletes the mucous protective layer in the colo-rectum, and c-Myc, which stimulates the growth of cancerous cells.
Keywords	Helicobacter pylori, colorectal cancer, Cag-A, MUC-2
ANZSRC Field of Research 2020	310701. Bacteriology
	320701. Medical bacteriology
Public Notes	File reproduced in accordance with the copyright policy of the publisher/author.
Byline Affiliations	Al-Nahrain University, Iraq
	University of Adelaide
	University of Putra Malaysia, Malaysia
Institution of Origin	University of Southern Queensland

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