The interplay between p53 and p21 tumor suppressor proteins in the transformation of colorectal adenoma to carcinoma

Article

Abdulamir, A. S., Hafidh, R. R., Mahdi, L. K., Al-jeboori, T. R., Abu bakar, F. and Abbas, K. A.. 2008. "The interplay between p53 and p21 tumor suppressor proteins in the transformation of colorectal adenoma to carcinoma." American Journal of Immunology. 4 (2), pp. 14-22. https://doi.org/10.3844/ajisp.2008.14.22

Article Title	The interplay between p53 and p21 tumor suppressor proteins in the transformation of colorectal adenoma to carcinoma
ERA Journal ID	15543
Article Category	Article
Authors	Abdulamir, A. S. (Author), Hafidh, R. R. (Author), Mahdi, L. K. (Author), Al-jeboori, T. R. (Author), Abu bakar, F. (Author) and Abbas, K. A. (Author)
Journal Title	American Journal of Immunology
Journal Citation	4 (2), pp. 14-22
Number of Pages	9
Year	2008
Place of Publication	United States
ISSN	1553-619X
	1558-3775
Digital Object Identifier (DOI)	https://doi.org/10.3844/ajisp.2008.14.22
Web Address (URL)	http://thescipub.com/abstract/10.3844/ajisp.2008.14.22
Abstract	This study was carried out for evaluating the interplay of p53, p21 and Ki-67 proteins along the colorectal adenoma-carcinoma oncogenic transformation sequel. Therefore, Fifty colorectal cancer and 14 adenoma patients were involved. The histopathological expression of p53, p21 and Ki-67 proteins was evaluated by immunohistochemistry assay. The results revealed that remarkable overexpression of p53 protein was seen in the tumorous sections of cancer patients more than that in adenoma patients (p<0.05), while no p53 overexpression was found in the corresponding non-tumorous sections. The positive expression of p21 protein was lower in the tumorous sections of cancer patients than that of adenoma patients (p<0.05) and was higher in the non-tumorous than the corresponding tumorous sections of both CRC and adenoma patients (p<0.05). The expression of p53 and p21 proteins in cancer patients was inversely correlated to each other (p<0.05) and the expression of p21 rather than p53 protein was associated with colorectal cancer staging and grading (p<0.05). Ki-67 was higher in cancer than in adenoma patients and higher in the tumorous tissue sections than the corresponding non-tumorous sections (p<0.05). The overexpression of p53 and downexpression of p21 proteins in colorectal cancer might be responsible largely for triggering the transformational changes in normal mucosa to develop adenoma and trigger also the malignant cascade from adenoma to carcinoma. P53 overexpression was shown to occur due to the mutated dysfunctional p53 gene product which loses its transcriptional activator necessary for p21 expression. The level of p21 protein which is a quantitatively affected by the loss of p53 activation is responsible for the association with cancer staging and grading that serves as a good indicator for the disease progression.
Keywords	colorectal cancer, adenoma, p53, p21, Ki-67
ANZSRC Field of Research 2020	310199. Biochemistry and cell biology not elsewhere classified
	320409. Tumour immunology
Byline Affiliations	Al-Nahrain University, Iraq
	University of Putra Malaysia, Malaysia
	University of Adelaide
Institution of Origin	University of Southern Queensland

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