In vitro anti-Leishmanial effects of black tea extract components
Article
Article Title | In vitro anti-Leishmanial effects of black tea extract components |
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ERA Journal ID | 17618 |
Article Category | Article |
Authors | Mahdi, H. S. (Author), Al-Bashir, N. M (Author), Saour, K. Y. (Author) and Mahdi, L. Kh. (Author) |
Journal Title | Jordan Journal of Applied Science: Natural Science |
Journal Citation | 7 (2), pp. 38-50 |
Number of Pages | 13 |
Year | 2005 |
Place of Publication | Jordan |
ISSN | 1605-2587 |
Web Address (URL) | http://ondemand.bl.uk/onDemand/itemDetails/show/ETOCRN172721070 |
Abstract | Four components of black tea extract (tannic acid, caffeine, theophylline and theobromine) exhibited antileishmanial activity against L. donovani, L. tropica and L. major, in both promastigote and axenic amastigote stages. All components showed antileishmanial activity against the three species. The concentration used ranged between (0.623-3) mg/ml. It was found that tannic acid had the greater effect on Leishmania species than other components, with ED50 range between (0.025-0.05) mg/ml after three days of exposure. Caffeine and theophylline showed a potent activity against the three species of Leishmania, with ED50 range between (0.035-1) mg/ml and (0.5-1) mg/ml respectively. In contrast the ED50 for theobromine ranged between (0.72-3) mg\ml. These results suggest further assessment of the four components of tea extract in infected laboratory animals and in humans against Leishmania infections. |
Keywords | Black tea; Leishmania |
ANZSRC Field of Research 2020 | 310101. Analytical biochemistry |
320704. Medical parasitology | |
310799. Microbiology not elsewhere classified | |
Public Notes | There are no files associated with this item. |
Byline Affiliations | University of Baghdad, Iraq |
No affiliation | |
Al-Nahrain University, Iraq | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q35y3/in-vitro-anti-leishmanial-effects-of-black-tea-extract-components
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