In vitro anti-Leishmanial effects of black tea extract components

Article

Mahdi, H. S., Al-Bashir, N. M, Saour, K. Y. and Mahdi, L. Kh.. 2005. "In vitro anti-Leishmanial effects of black tea extract components." Jordan Journal of Applied Science: Natural Science. 7 (2), pp. 38-50.
Article Title

In vitro anti-Leishmanial effects of black tea extract components

ERA Journal ID17618
Article CategoryArticle
AuthorsMahdi, H. S. (Author), Al-Bashir, N. M (Author), Saour, K. Y. (Author) and Mahdi, L. Kh. (Author)
Journal TitleJordan Journal of Applied Science: Natural Science
Journal Citation7 (2), pp. 38-50
Number of Pages13
Year2005
Place of PublicationJordan
ISSN1605-2587
Web Address (URL)http://ondemand.bl.uk/onDemand/itemDetails/show/ETOCRN172721070
Abstract

Four components of black tea extract (tannic acid, caffeine, theophylline and theobromine) exhibited antileishmanial activity against L. donovani, L. tropica and L. major, in both promastigote and axenic amastigote stages. All components showed antileishmanial activity against the three species. The concentration used ranged between (0.623-3) mg/ml. It was found that tannic acid had the greater effect on Leishmania species than other components, with ED50 range between (0.025-0.05) mg/ml after three days of exposure. Caffeine and theophylline showed a potent activity against the three species of Leishmania, with ED50 range between (0.035-1) mg/ml and (0.5-1) mg/ml respectively. In contrast the ED50 for theobromine ranged between (0.72-3) mg\ml. These results suggest further assessment of the four components of tea extract in infected laboratory animals and in humans against Leishmania infections.

KeywordsBlack tea; Leishmania
ANZSRC Field of Research 2020310101. Analytical biochemistry
320704. Medical parasitology
310799. Microbiology not elsewhere classified
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Byline AffiliationsUniversity of Baghdad, Iraq
No affiliation
Al-Nahrain University, Iraq
Institution of OriginUniversity of Southern Queensland
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