A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections
Article
Blaskovich, Mark A. T., Hansford, Karl A., Butler, Mark S., Ramu, Soumya, Kavanagh, Angela M., Jarrad, Angie M., Prasetyoputri, Anggia, Pitt, Miranda E., Huang, J. X., Lindahl F., Ziora Z.M., Bradford T., Muldoon C., Rajaratnam P., Pelingon R., Edwards D.J., Zhang B., Amado M., Elliott A.G., ..., Cooper M.A.. 2022. "A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections." Science Translational Medicine. 14 (662), pp. 1-16. https://doi.org/10.1126/scitranslmed.abj2381
| Article Title | A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections |
|---|---|
| ERA Journal ID | 123655 |
| Article Category | Article |
| Authors | Blaskovich, Mark A. T., Hansford, Karl A., Butler, Mark S., Ramu, Soumya, Kavanagh, Angela M., Jarrad, Angie M., Prasetyoputri, Anggia, Pitt, Miranda E., Huang, J. X., Lindahl F., Ziora Z.M., Bradford T., Muldoon C., Rajaratnam P., Pelingon R., Edwards D.J., Zhang B., Amado M., Elliott A.G., Zuegg J., Coin L., Woischnig A.K., Khanna N., Breidenstein E., Stincone A., Mason C., Khan N., Cho H.K., Karau M.J., Greenwood-Quaintance K.E., Patel R., Wootton M., James M.L., Hutton M.L., Lyras D., Ogunniyi A.D., Mahdi, L. K., Trott D.J., Wu X., Niles S., Lewis K., Smith J.R., Barber K.E., Yim J., Rice S.A., Rybak M.J., Ishmael C.R., Hori K.R., Bernthal N.M., Francis K.P., Roberts J.A., Paterson D.L. and Cooper M.A. |
| Journal Title | Science Translational Medicine |
| Journal Citation | 14 (662), pp. 1-16 |
| Article Number | abj2381 |
| Number of Pages | 16 |
| Year | 2022 |
| Place of Publication | United States |
| ISSN | 1946-6234 |
| 1946-6242 | |
| Digital Object Identifier (DOI) | https://doi.org/10.1126/scitranslmed.abj2381 |
| Web Address (URL) | https://www.science.org/doi/10.1126/scitranslmed.abj2381 |
| Abstract | Drug-resistant Gram-positive bacterial infections are still a substantial burden on the public health system, with two bacteria (Staphylococcus aureus and Streptococcus pneumoniae) accounting for over 1.5 million drug-resistant infections in the United States alone in 2017. In 2019, 250,000 deaths were attributed to these pathogens globally. We have developed a preclinical glycopeptide antibiotic, MCC5145, that has excellent potency (MIC90 ≤ 0.06 μg/ml) against hundreds of isolates of methicillin-resistant S. aureus (MRSA) and other Gram-positive bacteria, with a greater than 1000-fold margin over mammalian cell cytotoxicity values. The antibiotic has therapeutic in vivo efficacy when dosed subcutaneously in multiple murine models of established bacterial infections, including thigh infection with MRSA and blood septicemia with S. pneumoniae, as well as when dosed orally in an antibiotic-induced Clostridioides difficile infection model. MCC5145 exhibited reduced nephrotoxicity at microbiologically active doses in mice compared to vancomycin. MCC5145 also showed improved activity against biofilms compared to vancomycin, both in vitro and in vivo, and a low propensity to select for drug resistance. Characterization of drug action using a transposon library bioinformatic platform showed a mechanistic distinction from other glycopeptide antibiotics. |
| Byline Affiliations | University of Queensland |
| University of Adelaide | |
| Library Services |
Permalink -
https://research.usq.edu.au/item/wv593/a-lipoglycopeptide-antibiotic-for-gram-positive-biofilm-related-infections
47
total views1
total downloads2
views this month0
downloads this month
Export as
Related outputs
Talcarpones A and B: bisnaphthazarin-derived metabolites from the Australian fungus Talaromyces johnpittii sp. nov. MST-FP2594
Lacey, Alastair E., Minns, Scott A., Chen, Rachel, Vuong, Daniel, Lacey, Ernest, Kalaitzis, John A., Tan, Yu Pei, Shivas, Roger G., Butler, Mark S. and Piggott, Andrew M.. 2024. "Talcarpones A and B: bisnaphthazarin-derived metabolites from the Australian fungus Talaromyces johnpittii sp. nov. MST-FP2594." The Journal of Antibiotics. 77 (3), pp. 147-155. https://doi.org/10.1038/s41429-023-00688-xCorrection: Alhamami et al. First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia. Microorganisms 2021, 9, 1322
Alhamami, Tamara, Chowdhury, Piklu Roy, Gomes, Nancy, Carr, Mandi, Veltman, Tania, Khazandi, Manouchehr, Mollinger, Joanne, Deutscher, Ania T., Turni, Conny, Mahdi, Layla, Venter, Henrietta, Abraham, Sam, Djordjevic, Steven P. and Trott, D.. 2022. "Correction: Alhamami et al. First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia. Microorganisms 2021, 9, 1322." Microorganisms. 10 (4), pp. 1-2. https://doi.org/10.3390/microorganisms10040825Progress in the pathobiology and genetic epidemiology of Campylobacter hepaticus, the aetiological agent of Spotty Liver Disease
Kotiw, M., Courtice, J., Mahdi, L., Wei, C., Ahmad, T., Hancock, K. and Groves, P.. 2019. "Progress in the pathobiology and genetic epidemiology of Campylobacter hepaticus, the aetiological agent of Spotty Liver Disease." 2019 Australasian Veterinary Poultry Association (AVPA) Annual Scientific Meeting. Sydney, Australia 20 - 21 Feb 2019Spotty Liver Disease: A review of an ongoing challenge in commercial free-range egg production
Courtice, Jodi Maree, Mahdi, Layla Khalid, Groves, Peter John and Kotiw, Michael. 2018. "Spotty Liver Disease: A review of an ongoing challenge in commercial free-range egg production." Veterinary Microbiology. 227, pp. 112-118. https://doi.org/10.1016/j.vetmic.2018.08.004First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia
Alhamami, Tamara, Chowdhury, Piklu Roy, Gomes, Nancy, Carr, Mandi, Veltman, Tania, Khazandi, Manouchehr, Mollinger, Joanne, Deutscher, Ania T., Turni, Conny, Mahdi, Layla, Venter, Henrietta, Abraham, Sam, Djordjevic, Steven P. and Trott, Darren J.. 2021. "First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia." Microorganisms. 9 (6), pp. 1-17. https://doi.org/10.3390/microorganisms9061322Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury
Ahmad, Tarek B., Rudd, David, Benkendorff, Kirsten, Mahdi, Layla K., Pratt, Kayla-Ann, Dooley, Leanne, Wei, Chuanyu and Kotiw, Michael. 2017. "Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury." PLoS One. 12 (10). https://doi.org/10.1371/journal.pone.0186904The pneumococcal alpha-glycerophosphate oxidase enhances nasopharyngeal colonization through binding to host glycoconjugates
Mahdi, Layla K., Higgins, Melanie A., Day, Christopher J., Tiralongo, Joe, Hartley-Tassell, Lauren E., Jennings, Michael P., Gordon, David L., Paton, Adrienne W., Paton, James C. and Ogunniyi, Abiodun D.. 2017. "The pneumococcal alpha-glycerophosphate oxidase enhances nasopharyngeal colonization through binding to host glycoconjugates." EBioMedicine. 18, pp. 236-243. https://doi.org/10.1016/j.ebiom.2017.03.002Application of RAPD- PCR to differentiate among Aeromonas spp
Jaladet, M. S. J., M., Layla Kh. and Zaineb, M. N.. 2004. "Application of RAPD- PCR to differentiate among Aeromonas spp ." Journal of Al-Nahrain University. 7, pp. 48-56.Chemical characterization and anti-bacterial activity of black tea extract components
Mahdi, H. S., Mahdi, L. Kh. and Saour, K. Y.. 2005. "Chemical characterization and anti-bacterial activity of black tea extract components ." Journal of The Faculty of Medicine Baghdad. 47 (2), pp. 174-178.Preparation of C-reactive protein latex reagent of human serum
Alshalchi, Sahar A., Mahdi, Layla K. and Sabar, Muna. 2006. "Preparation of C-reactive protein latex reagent of human serum ." Iraqi Journal of Biotechnology. 5 (1), pp. 112-122.The variable region of the pneumococcal pathogenicity island 1 is responsible for the unusually high virulence of a serotype 1 isolate
Harvey, Richard M., Trappetti, Claudia, Mahdi, Layla K., Wang, Hui, McAllister, Lauren J., Scalvini, Alexandra, Paton, Adrienne W. and Paton, James C.. 2016. "The variable region of the pneumococcal pathogenicity island 1 is responsible for the unusually high virulence of a serotype 1 isolate." Infection and Immunity. 84 (3), pp. 822-832. https://doi.org/10.1128/IAI.01454-15A functional genomics catalogue of activated transcription factors during pathogenesis of pneumococcal disease
Mahdi, Layla K., Deihim, Tahereh, Zamansani, Fatemeh, Fruzangohar, Mario, Adelson, David L., Paton, James C., Ogunniyi, Abiodun D. and Ebrahimie, Esmaeil. 2014. "A functional genomics catalogue of activated transcription factors during pathogenesis of pneumococcal disease." BMC Genomics. 15 (1), pp. 1-15. https://doi.org/10.1186/1471-2164-15-769Comparative GO: a web application for comparative gene ontology and gene ontology-based gene selection in bacteria
Fruzangohar, Mario, Ebrahimie, Esmaeil, Ogunniyi, Abiodun D., Mahdi, Layla K., Paton, James C. and Adelson, David L.. 2013. "Comparative GO: a web application for comparative gene ontology and gene ontology-based gene selection in bacteria." PLoS One. 8 (3), pp. e58759-e58767. https://doi.org/10.1371/journal.pone.0058759A transcription factor contributes to pathogenesis and virulence in Streptococcus pneumoniae
Mahdi, Layla K., Ebrahimie, Esmaeil, Adelson, David L., Paton, James C. and Ogunniyi, Abiodun D.. 2013. "A transcription factor contributes to pathogenesis and virulence in Streptococcus pneumoniae." PLoS One. 8 (8), pp. e70862-e70871. https://doi.org/10.1371/journal.pone.0070862Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice
Mahdi, Layla K., Wang, Hui, Van der Hoek, Mark B., Paton, James C. and Ogunniyi, Abiodun D.. 2012. "Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice." Journal of Clinical Investigation. 122 (6), pp. 2208-2220. https://doi.org/10.1172/JCI45850Identification of genes that contribute to the pathogenesis of invasive Pneumococcal Disease by In Vivo transcriptomic analysis
Ogunniyi, Abiodun D., Mahdi, Layla K., Trappetti, Claudia, Verhoeven, Nadine, Mermans, Daphne, Van der Hoek, Mark B., Plumptre, Charles D. and Paton, James C.. 2012. "Identification of genes that contribute to the pathogenesis of invasive Pneumococcal Disease by In Vivo transcriptomic analysis." Infection and Immunity. 80 (9), pp. 3268-3278. https://doi.org/10.1128/IAI.00295-12Characterization of pneumococcal genes involved in bloodstream invasion in a mouse model
Mahdi, Layla K., Van der Hoek, Mark B., Ebrahimie, Esmaeil, Paton, James C. and Ogunniyi, Abiodun D.. 2015. "Characterization of pneumococcal genes involved in bloodstream invasion in a mouse model." PLoS One. 10 (11), pp. 1-15. https://doi.org/10.1371/journal.pone.0141816Correction: Comparative GO: A Web Application for Comparative Gene Ontology and Gene Ontology-Based Gene Selection in Bacteria
Fruzangohar, Mario, Ebrahimie, Esmaeil, Ogunniyi, Abiodun D., Mahdi, Layla K., Paton, James C. and Adelson, David L.. 2015. "Correction: Comparative GO: A Web Application for Comparative Gene Ontology and Gene Ontology-Based Gene Selection in Bacteria." PLoS One. 10 (4). https://doi.org/10.1371/journal.pone.0125537Association of Helicobacter pylori with colorectal cancer development
Alsamak, Fadi Fouad, Abdulamir, Ahmed Sahib, Mahdi, Layla Khalid, Alnaib, Khalid and Abu Bakar, Fatimah. 2010. "Association of Helicobacter pylori with colorectal cancer development." Asian Biomedicine. 4 (4), pp. 609-618.Central role of manganese in regulation of stress responses, physiology, and metabolism in streptococcus pneumoniae
Ogunniyi, Abiodun D., Mahdi, Layla K., Jennings, Michael P., McEwan, Alastair G., McDevitt, Christopher A., Van der Hoek, Mark B., Bagley, Christopher J., Hoffmann, Peter, Gould, Katherine A. and Paton, James C.. 2010. "Central role of manganese in regulation of stress responses, physiology, and metabolism in streptococcus pneumoniae." Journal of Bacteriology. 192 (17), pp. 4489-4497. https://doi.org/10.1128/JB.00064-10Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenoma
Abdulamir, Ahmed S., Hafidh, Rand R., Mahdi, Layla K., Al-jeboori, Tarik and Abu bakar, Fatimah. 2009. "Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenoma." BMC Cancer. 9 (1), pp. 403-415. https://doi.org/10.1186/1471-2407-9-403Pneumococcal histidine triad proteins are regulated by the Zn2+-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H
Ogunniyi, Abiodun D., Grabowicz, Marcin, Mahdi, Layla K., Cook, Jan, Gordon, David L., Sadlon, Tania A. and Paton, James C.. 2009. "Pneumococcal histidine triad proteins are regulated by the Zn2+-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H." The FASEB Journal. 23 (3), pp. 731-738. https://doi.org/10.1096/fj.08-119537The interplay between p53 and p21 tumor suppressor proteins in the transformation of colorectal adenoma to carcinoma
Abdulamir, A. S., Hafidh, R. R., Mahdi, L. K., Al-jeboori, T. R., Abu bakar, F. and Abbas, K. A.. 2008. "The interplay between p53 and p21 tumor suppressor proteins in the transformation of colorectal adenoma to carcinoma." American Journal of Immunology. 4 (2), pp. 14-22. https://doi.org/10.3844/ajisp.2008.14.22Pneumococcal virulence gene expression and host cytokine profiles during pathogenesis of invasive disease
Mahdi, Layla K., Ogunniyi, Abiodun D., LeMessurier, Kim S. and Paton, James C.. 2008. "Pneumococcal virulence gene expression and host cytokine profiles during pathogenesis of invasive disease ." Infection and Immunity. 76 (2), pp. 646-657. https://doi.org/10.1128/IAI.01161-07Prevalence and etiology of urinary stones in hospitalized patients in Baghdad
Qaader, D. S., Yousif, S. Y. and Mahdi, L. K.. 2006. "Prevalence and etiology of urinary stones in hospitalized patients in Baghdad." Eastern Mediterranean Health Journal. 12 (6), pp. 853-861.In vitro anti-Leishmanial effects of black tea extract components
Mahdi, H. S., Al-Bashir, N. M, Saour, K. Y. and Mahdi, L. Kh.. 2005. "In vitro anti-Leishmanial effects of black tea extract components." Jordan Journal of Applied Science: Natural Science. 7 (2), pp. 38-50.First report of Escherichia coli O157 among Iraqi children
Shebib, Z. A., Abdul Ghani, Z. G. and Mahdi, L. Kh.. 2003. "First report of Escherichia coli O157 among Iraqi children." Eastern Mediterranean Health Journal. 9 (1-2), pp. 159-166.This item comprises data from the following sources: Scopus