Talcarpones A and B: bisnaphthazarin-derived metabolites from the Australian fungus Talaromyces johnpittii sp. nov. MST-FP2594
Article
Lacey, Alastair E., Minns, Scott A., Chen, Rachel, Vuong, Daniel, Lacey, Ernest, Kalaitzis, John A., Tan, Yu Pei, Shivas, Roger G., Butler, Mark S. and Piggott, Andrew M.. 2024. "Talcarpones A and B: bisnaphthazarin-derived metabolites from the Australian fungus Talaromyces johnpittii sp. nov. MST-FP2594." The Journal of Antibiotics. 77 (3), pp. 147-155. https://doi.org/10.1038/s41429-023-00688-x
Article Title | Talcarpones A and B: bisnaphthazarin-derived metabolites from the Australian fungus Talaromyces johnpittii sp. nov. MST-FP2594 |
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ERA Journal ID | 2481 |
Article Category | Article |
Authors | Lacey, Alastair E., Minns, Scott A., Chen, Rachel, Vuong, Daniel, Lacey, Ernest, Kalaitzis, John A., Tan, Yu Pei, Shivas, Roger G., Butler, Mark S. and Piggott, Andrew M. |
Journal Title | The Journal of Antibiotics |
Journal Citation | 77 (3), pp. 147-155 |
Number of Pages | 9 |
Year | 2024 |
Publisher | Nature Publishing Group |
Place of Publication | United Kingdom |
ISSN | 0021-8820 |
1881-1469 | |
Digital Object Identifier (DOI) | https://doi.org/10.1038/s41429-023-00688-x |
Web Address (URL) | https://www.nature.com/articles/s41429-023-00688-x |
Abstract | Talcarpones A (1) and B (2) are rare bisnaphthazarin derivatives produced by Talaromyces johnpittii (ex-type strain MST-FP2594), a newly discovered Australian fungus, which is formally described and named herein. The talcarpones were isolated along with the previously reported monomeric naphthoquinone, aureoquinone (3), suggesting a biosynthetic link between these metabolites. Talcarpone A is a lower homologue of hybocarpone (4), which was first isolated from a mycobiont of the lichen Lecanora hybocarpa. The structures of 1 and 2 were elucidated by detailed spectroscopic analysis, molecular modelling and comparison with literature data. Talcarpones 1 and 2 exhibited moderate antifungal activity (MIC 0.78–3.1 µg ml−1) and weak activity against Gram-positive bacteria (MIC 13–25 µg ml−1). The talcarpones also demonstrated noteworthy chemical reactivities, with 2 converting rapidly to 1, which in turn converted slowly to the highly coloured 3. These post-biosynthetic reactions point to a potential ecological role for the talcarpones in providing ongoing (slow-release) physicochemical protection for T. johnpittii against solar irradiation. |
Contains Sensitive Content | Does not contain sensitive content |
ANZSRC Field of Research 2020 | 310705. Mycology |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Microbial Screening Technologies, Australia |
Macquarie University | |
Centre for Crop Health | |
Department of Agriculture and Fisheries, Queensland | |
MSBChem Consulting, Australia |
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