Geministatins: new depside antibiotics from the fungus Austroacremonium gemini
Article
Crombie, Andrew, Kalaitzis, John A., Chen, Rachel, Vuong, Daniel, Lacey, Alastair E., Lacey, Ernest, Shivas, Roger G., Tan, Yu Pei, Sbaraini, Nicolau, Chooi, Yit-Heng and Piggott, Andrew M.. 2024. "Geministatins: new depside antibiotics from the fungus Austroacremonium gemini." The Journal of Antibiotics. https://doi.org/10.1038/s41429-024-00755-x
Article Title | Geministatins: new depside antibiotics from the fungus Austroacremonium gemini |
---|---|
ERA Journal ID | 2481 |
Article Category | Article |
Authors | Crombie, Andrew, Kalaitzis, John A., Chen, Rachel, Vuong, Daniel, Lacey, Alastair E., Lacey, Ernest, Shivas, Roger G., Tan, Yu Pei, Sbaraini, Nicolau, Chooi, Yit-Heng and Piggott, Andrew M. |
Journal Title | The Journal of Antibiotics |
Number of Pages | 8 |
Year | 2024 |
Publisher | Nature Publishing Group |
ISSN | 0021-8820 |
1881-1469 | |
Digital Object Identifier (DOI) | https://doi.org/10.1038/s41429-024-00755-x |
Web Address (URL) | https://www.nature.com/articles/s41429-024-00755-x |
Abstract | Two new depside antibiotics, geministatins A (1) and B (2), were isolated from the fungus Austroacremonium gemini MST-FP2131 (Sordariomycetes, Ascomycota), which was recovered from rotting wood in the wet tropics of northern Australia. The structures of the geministatins were elucidated by detailed spectroscopic analysis, chemical degradation and comparison with literature values. Chemical degradation of 1 and 2 yielded three new analogues, geministatins C–E (3–5), as well as a previously reported compound dehydromerulinic acid A (6). Compounds 1, 2 and 6 exhibited antibacterial activity against the Gram-positive bacteria Bacillus subtilis (MIC 0.2–1.6 µg mL−1) and Staphylococcus aureus (MIC 0.78–6.3 µg mL−1), including methicillin-resistant S. aureus (MRSA), while 4 exhibited antifungal activity against the yeast Saccharomyces cerevisiae (MIC 13 µg mL−1). |
Contains Sensitive Content | Does not contain sensitive content |
ANZSRC Field of Research 2020 | 310705. Mycology |
Byline Affiliations | Microbial Screening Technologies, Australia |
Macquarie University | |
Plant Pathology Herbarium, Queensland | |
Centre for Crop Health | |
University of Western Australia |
Permalink -
https://research.usq.edu.au/item/z8497/geministatins-new-depside-antibiotics-from-the-fungus-austroacremonium-gemini
Download files
12
total views6
total downloads1
views this month1
downloads this month