A transcription factor contributes to pathogenesis and virulence in Streptococcus pneumoniae

Article


Mahdi, Layla K., Ebrahimie, Esmaeil, Adelson, David L., Paton, James C. and Ogunniyi, Abiodun D.. 2013. "A transcription factor contributes to pathogenesis and virulence in Streptococcus pneumoniae." PLoS One. 8 (8), pp. e70862-e70871. https://doi.org/10.1371/journal.pone.0070862
Article Title

A transcription factor contributes to pathogenesis and virulence in Streptococcus pneumoniae

ERA Journal ID39745
Article CategoryArticle
AuthorsMahdi, Layla K. (Author), Ebrahimie, Esmaeil (Author), Adelson, David L. (Author), Paton, James C. (Author) and Ogunniyi, Abiodun D. (Author)
Journal TitlePLoS One
Journal Citation8 (8), pp. e70862-e70871
Number of Pages10
Year2013
PublisherPublic Library of Science (PLoS)
Place of PublicationUnited States
ISSN1932-6203
Digital Object Identifier (DOI)https://doi.org/10.1371/journal.pone.0070862
Web Address (URL)http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070862
Abstract

To date, the role of transcription factors (TFs) in the progression of disease for many pathogens is yet to be studied in detail. This is probably due to transient, and generally low expression levels of TFs, which are the central components controlling the expression of many genes during the course of infection. However, a small change in the expression or specificity of a TF can radically alter gene expression. In this study, we combined a number of quality-based selection strategies including structural prediction of modulated genes, gene ontology and network analysis, to predict the regulatory mechanisms underlying pathogenesis of Streptococcus pneumoniae (the pneumococcus). We have identified two TFs (SP_0676 and SP_0927 [SmrC]) that might control tissue-specific gene expression during pneumococcal translocation from the nasopharynx to lungs, to blood and then to brain of mice. Targeted mutagenesis and mouse models of infection confirmed the role of SP_0927 in pathogenesis and virulence, and suggests that SP_0676 might be essential to pneumococcal viability. These findings provide fundamental new insights into virulence gene expression and regulation during pathogenesis.

ANZSRC Field of Research 2020310704. Microbial genetics
310701. Bacteriology
320701. Medical bacteriology
Byline AffiliationsUniversity of Adelaide
Institution of OriginUniversity of Southern Queensland
Funding source
NHMRC
Grant ID
627142
Funding source
NHMRC
Grant ID
565526
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