A transcription factor contributes to pathogenesis and virulence in Streptococcus pneumoniae

Article


Mahdi, Layla K., Ebrahimie, Esmaeil, Adelson, David L., Paton, James C. and Ogunniyi, Abiodun D.. 2013. "A transcription factor contributes to pathogenesis and virulence in Streptococcus pneumoniae." PLoS One. 8 (8), pp. e70862-e70871. https://doi.org/10.1371/journal.pone.0070862
Article Title

A transcription factor contributes to pathogenesis and virulence in Streptococcus pneumoniae

ERA Journal ID39745
Article CategoryArticle
AuthorsMahdi, Layla K. (Author), Ebrahimie, Esmaeil (Author), Adelson, David L. (Author), Paton, James C. (Author) and Ogunniyi, Abiodun D. (Author)
Journal TitlePLoS One
Journal Citation8 (8), pp. e70862-e70871
Number of Pages10
Year2013
PublisherPublic Library of Science (PLoS)
Place of PublicationUnited States
ISSN1932-6203
Digital Object Identifier (DOI)https://doi.org/10.1371/journal.pone.0070862
Web Address (URL)http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070862
Abstract

To date, the role of transcription factors (TFs) in the progression of disease for many pathogens is yet to be studied in detail. This is probably due to transient, and generally low expression levels of TFs, which are the central components controlling the expression of many genes during the course of infection. However, a small change in the expression or specificity of a TF can radically alter gene expression. In this study, we combined a number of quality-based selection strategies including structural prediction of modulated genes, gene ontology and network analysis, to predict the regulatory mechanisms underlying pathogenesis of Streptococcus pneumoniae (the pneumococcus). We have identified two TFs (SP_0676 and SP_0927 [SmrC]) that might control tissue-specific gene expression during pneumococcal translocation from the nasopharynx to lungs, to blood and then to brain of mice. Targeted mutagenesis and mouse models of infection confirmed the role of SP_0927 in pathogenesis and virulence, and suggests that SP_0676 might be essential to pneumococcal viability. These findings provide fundamental new insights into virulence gene expression and regulation during pathogenesis.

ANZSRC Field of Research 2020310704. Microbial genetics
310701. Bacteriology
320701. Medical bacteriology
Byline AffiliationsUniversity of Adelaide
Institution of OriginUniversity of Southern Queensland
Funding source
NHMRC
Grant ID
627142
Funding source
NHMRC
Grant ID
565526
Permalink -

https://research.usq.edu.au/item/q35x0/a-transcription-factor-contributes-to-pathogenesis-and-virulence-in-streptococcus-pneumoniae

Download files


Published Version
Mahdi-2013.pdf
License: CC BY 4.0
File access level: Anyone

  • 1640
    total views
  • 111
    total downloads
  • 2
    views this month
  • 1
    downloads this month

Export as

Related outputs

Correction: Alhamami et al. First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia. Microorganisms 2021, 9, 1322
Alhamami, Tamara, Chowdhury, Piklu Roy, Gomes, Nancy, Carr, Mandi, Veltman, Tania, Khazandi, Manouchehr, Mollinger, Joanne, Deutscher, Ania T., Turni, Conny, Mahdi, Layla, Venter, Henrietta, Abraham, Sam, Djordjevic, Steven P. and Trott, D.. 2022. "Correction: Alhamami et al. First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia. Microorganisms 2021, 9, 1322." Microorganisms. 10 (4), pp. 1-2. https://doi.org/10.3390/microorganisms10040825
A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections
Blaskovich, Mark A. T., Hansford, Karl A., Butler, Mark S., Ramu, Soumya, Kavanagh, Angela M., Jarrad, Angie M., Prasetyoputri, Anggia, Pitt, Miranda E., Huang, J. X., Lindahl F., Ziora Z.M., Bradford T., Muldoon C., Rajaratnam P., Pelingon R., Edwards D.J., Zhang B., Amado M., Elliott A.G., ..., Cooper M.A.. 2022. "A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections." Science Translational Medicine. 14 (662), pp. 1-16. https://doi.org/10.1126/scitranslmed.abj2381
Progress in the pathobiology and genetic epidemiology of Campylobacter hepaticus, the aetiological agent of Spotty Liver Disease
Kotiw, M., Courtice, J., Mahdi, L., Wei, C., Ahmad, T., Hancock, K. and Groves, P.. 2019. "Progress in the pathobiology and genetic epidemiology of Campylobacter hepaticus, the aetiological agent of Spotty Liver Disease." 2019 Australasian Veterinary Poultry Association (AVPA) Annual Scientific Meeting. Sydney, Australia 20 - 21 Feb 2019
Spotty Liver Disease: A review of an ongoing challenge in commercial free-range egg production
Courtice, Jodi Maree, Mahdi, Layla Khalid, Groves, Peter John and Kotiw, Michael. 2018. "Spotty Liver Disease: A review of an ongoing challenge in commercial free-range egg production." Veterinary Microbiology. 227, pp. 112-118. https://doi.org/10.1016/j.vetmic.2018.08.004
First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia
Alhamami, Tamara, Chowdhury, Piklu Roy, Gomes, Nancy, Carr, Mandi, Veltman, Tania, Khazandi, Manouchehr, Mollinger, Joanne, Deutscher, Ania T., Turni, Conny, Mahdi, Layla, Venter, Henrietta, Abraham, Sam, Djordjevic, Steven P. and Trott, Darren J.. 2021. "First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia." Microorganisms. 9 (6), pp. 1-17. https://doi.org/10.3390/microorganisms9061322
Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury
Ahmad, Tarek B., Rudd, David, Benkendorff, Kirsten, Mahdi, Layla K., Pratt, Kayla-Ann, Dooley, Leanne, Wei, Chuanyu and Kotiw, Michael. 2017. "Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury." PLoS One. 12 (10). https://doi.org/10.1371/journal.pone.0186904
The pneumococcal alpha-glycerophosphate oxidase enhances nasopharyngeal colonization through binding to host glycoconjugates
Mahdi, Layla K., Higgins, Melanie A., Day, Christopher J., Tiralongo, Joe, Hartley-Tassell, Lauren E., Jennings, Michael P., Gordon, David L., Paton, Adrienne W., Paton, James C. and Ogunniyi, Abiodun D.. 2017. "The pneumococcal alpha-glycerophosphate oxidase enhances nasopharyngeal colonization through binding to host glycoconjugates." EBioMedicine. 18, pp. 236-243. https://doi.org/10.1016/j.ebiom.2017.03.002
Application of RAPD- PCR to differentiate among Aeromonas spp
Jaladet, M. S. J., M., Layla Kh. and Zaineb, M. N.. 2004. "Application of RAPD- PCR to differentiate among Aeromonas spp ." Journal of Al-Nahrain University. 7, pp. 48-56.
Chemical characterization and anti-bacterial activity of black tea extract components
Mahdi, H. S., Mahdi, L. Kh. and Saour, K. Y.. 2005. "Chemical characterization and anti-bacterial activity of black tea extract components ." Journal of The Faculty of Medicine Baghdad. 47 (2), pp. 174-178.
Preparation of C-reactive protein latex reagent of human serum
Alshalchi, Sahar A., Mahdi, Layla K. and Sabar, Muna. 2006. "Preparation of C-reactive protein latex reagent of human serum ." Iraqi Journal of Biotechnology. 5 (1), pp. 112-122.
The variable region of the pneumococcal pathogenicity island 1 is responsible for the unusually high virulence of a serotype 1 isolate
Harvey, Richard M., Trappetti, Claudia, Mahdi, Layla K., Wang, Hui, McAllister, Lauren J., Scalvini, Alexandra, Paton, Adrienne W. and Paton, James C.. 2016. "The variable region of the pneumococcal pathogenicity island 1 is responsible for the unusually high virulence of a serotype 1 isolate." Infection and Immunity. 84 (3), pp. 822-832. https://doi.org/10.1128/IAI.01454-15
A functional genomics catalogue of activated transcription factors during pathogenesis of pneumococcal disease
Mahdi, Layla K., Deihim, Tahereh, Zamansani, Fatemeh, Fruzangohar, Mario, Adelson, David L., Paton, James C., Ogunniyi, Abiodun D. and Ebrahimie, Esmaeil. 2014. "A functional genomics catalogue of activated transcription factors during pathogenesis of pneumococcal disease." BMC Genomics. 15 (1), pp. 1-15. https://doi.org/10.1186/1471-2164-15-769
Comparative GO: a web application for comparative gene ontology and gene ontology-based gene selection in bacteria
Fruzangohar, Mario, Ebrahimie, Esmaeil, Ogunniyi, Abiodun D., Mahdi, Layla K., Paton, James C. and Adelson, David L.. 2013. "Comparative GO: a web application for comparative gene ontology and gene ontology-based gene selection in bacteria." PLoS One. 8 (3), pp. e58759-e58767. https://doi.org/10.1371/journal.pone.0058759
Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice
Mahdi, Layla K., Wang, Hui, Van der Hoek, Mark B., Paton, James C. and Ogunniyi, Abiodun D.. 2012. "Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice." Journal of Clinical Investigation. 122 (6), pp. 2208-2220. https://doi.org/10.1172/JCI45850
Identification of genes that contribute to the pathogenesis of invasive Pneumococcal Disease by In Vivo transcriptomic analysis
Ogunniyi, Abiodun D., Mahdi, Layla K., Trappetti, Claudia, Verhoeven, Nadine, Mermans, Daphne, Van der Hoek, Mark B., Plumptre, Charles D. and Paton, James C.. 2012. "Identification of genes that contribute to the pathogenesis of invasive Pneumococcal Disease by In Vivo transcriptomic analysis." Infection and Immunity. 80 (9), pp. 3268-3278. https://doi.org/10.1128/IAI.00295-12
Characterization of pneumococcal genes involved in bloodstream invasion in a mouse model
Mahdi, Layla K., Van der Hoek, Mark B., Ebrahimie, Esmaeil, Paton, James C. and Ogunniyi, Abiodun D.. 2015. "Characterization of pneumococcal genes involved in bloodstream invasion in a mouse model." PLoS One. 10 (11), pp. 1-15. https://doi.org/10.1371/journal.pone.0141816
Correction: Comparative GO: A Web Application for Comparative Gene Ontology and Gene Ontology-Based Gene Selection in Bacteria
Fruzangohar, Mario, Ebrahimie, Esmaeil, Ogunniyi, Abiodun D., Mahdi, Layla K., Paton, James C. and Adelson, David L.. 2015. "Correction: Comparative GO: A Web Application for Comparative Gene Ontology and Gene Ontology-Based Gene Selection in Bacteria." PLoS One. 10 (4). https://doi.org/10.1371/journal.pone.0125537
Association of Helicobacter pylori with colorectal cancer development
Alsamak, Fadi Fouad, Abdulamir, Ahmed Sahib, Mahdi, Layla Khalid, Alnaib, Khalid and Abu Bakar, Fatimah. 2010. "Association of Helicobacter pylori with colorectal cancer development." Asian Biomedicine. 4 (4), pp. 609-618.
Central role of manganese in regulation of stress responses, physiology, and metabolism in streptococcus pneumoniae
Ogunniyi, Abiodun D., Mahdi, Layla K., Jennings, Michael P., McEwan, Alastair G., McDevitt, Christopher A., Van der Hoek, Mark B., Bagley, Christopher J., Hoffmann, Peter, Gould, Katherine A. and Paton, James C.. 2010. "Central role of manganese in regulation of stress responses, physiology, and metabolism in streptococcus pneumoniae." Journal of Bacteriology. 192 (17), pp. 4489-4497. https://doi.org/10.1128/JB.00064-10
Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenoma
Abdulamir, Ahmed S., Hafidh, Rand R., Mahdi, Layla K., Al-jeboori, Tarik and Abu bakar, Fatimah. 2009. "Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenoma." BMC Cancer. 9 (1), pp. 403-415. https://doi.org/10.1186/1471-2407-9-403
Pneumococcal histidine triad proteins are regulated by the Zn2+-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H
Ogunniyi, Abiodun D., Grabowicz, Marcin, Mahdi, Layla K., Cook, Jan, Gordon, David L., Sadlon, Tania A. and Paton, James C.. 2009. "Pneumococcal histidine triad proteins are regulated by the Zn2+-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H." The FASEB Journal. 23 (3), pp. 731-738. https://doi.org/10.1096/fj.08-119537
The interplay between p53 and p21 tumor suppressor proteins in the transformation of colorectal adenoma to carcinoma
Abdulamir, A. S., Hafidh, R. R., Mahdi, L. K., Al-jeboori, T. R., Abu bakar, F. and Abbas, K. A.. 2008. "The interplay between p53 and p21 tumor suppressor proteins in the transformation of colorectal adenoma to carcinoma." American Journal of Immunology. 4 (2), pp. 14-22. https://doi.org/10.3844/ajisp.2008.14.22
Pneumococcal virulence gene expression and host cytokine profiles during pathogenesis of invasive disease
Mahdi, Layla K., Ogunniyi, Abiodun D., LeMessurier, Kim S. and Paton, James C.. 2008. "Pneumococcal virulence gene expression and host cytokine profiles during pathogenesis of invasive disease ." Infection and Immunity. 76 (2), pp. 646-657. https://doi.org/10.1128/IAI.01161-07
Prevalence and etiology of urinary stones in hospitalized patients in Baghdad
Qaader, D. S., Yousif, S. Y. and Mahdi, L. K.. 2006. "Prevalence and etiology of urinary stones in hospitalized patients in Baghdad." Eastern Mediterranean Health Journal. 12 (6), pp. 853-861.
In vitro anti-Leishmanial effects of black tea extract components
Mahdi, H. S., Al-Bashir, N. M, Saour, K. Y. and Mahdi, L. Kh.. 2005. "In vitro anti-Leishmanial effects of black tea extract components." Jordan Journal of Applied Science: Natural Science. 7 (2), pp. 38-50.
First report of Escherichia coli O157 among Iraqi children
Shebib, Z. A., Abdul Ghani, Z. G. and Mahdi, L. Kh.. 2003. "First report of Escherichia coli O157 among Iraqi children." Eastern Mediterranean Health Journal. 9 (1-2), pp. 159-166.