Rheumatic heart disease: A review of the current status of global research activity
Article
Article Title | Rheumatic heart disease: A review of the current status of global research activity |
---|---|
ERA Journal ID | 40469 |
Article Category | Article |
Authors | Dooley, Leanne M. (Author), Ahmad, Tarek B. (Author), Pandey, Manisha (Author), Good, Micheal F. (Author) and Kotiw, Michael (Author) |
Journal Title | Autoimmunity Reviews |
Journal Citation | 20 (2), pp. 1-23 |
Article Number | 102740 |
Number of Pages | 23 |
Year | 2021 |
Place of Publication | United States |
ISSN | 1568-9972 |
1873-0183 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.autrev.2020.102740 |
Web Address (URL) | http://www.sciencedirect.com/science/article/pii/S1568997220303219 |
Abstract | Rheumatic heart disease (RHD) is a serious and long-term consequence of acute rheumatic fever (ARF), an autoimmune sequela of a mucosal infection by Streptococcus pyogenes (Group A Streptococcus, Strep A). The pathogenesis of ARF and RHD is complex and not fully understood but involves host and bacterial factors, molecular mimicry, and aberrant host innate and adaptive immune responses that result in loss of self-tolerance and subsequent cross-reactivity with host tissues. RHD is entirely preventable yet claims an estimated 320 000 lives annually. The major burden of disease is carried by developing nations and Indigenous populations within developed nations, including Australia. This review will focus on the epidemiology, pathogenesis and treatment of ARF and RHD in Australia, where: streptococcal pyoderma, rather than streptococcal pharyngitis, and Group C and Group G Streptococcus, have been implicated as antecedents to ARF; the rates of RHD in remote Indigenous communities are persistently among the highest in the world; government register-based programs coordinate disease screening and delivery of prophylaxis with variable success; and researchers are making significant progress in the development of a broad-spectrum vaccine against Strep A. |
Keywords | Rheumatic fever; Rheumatic heart disease; Group A Streptococcus; M protein; Australian Aboriginal Vaccine |
Related Output | |
Is part of | The immunology of a putative recombinant vaccine against Streptococcus pyogenes utilising hepatitis B virus-like particles as an antigen delivery platform |
ANZSRC Field of Research 2020 | 320403. Autoimmunity |
450403. Aboriginal and Torres Strait Islander child health and wellbeing | |
320211. Infectious diseases | |
Public Notes | File reproduced in accordance with the copyright policy of the publisher/author. |
This article is part of a UniSQ Thesis by publication. See Related Output. | |
Byline Affiliations | School of Health and Wellbeing |
Institute for Life Sciences and the Environment | |
Griffith University | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q60v1/rheumatic-heart-disease-a-review-of-the-current-status-of-global-research-activity
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