In vitro effect of canine hyperimmune sera on TNFa activity

Article

Kotiw, Michael, Shiels, I. A., Wilson, R. P. and Reeve-Johnson, Lloyd. 2006. "In vitro effect of canine hyperimmune sera on TNFa activity." Journal of Veterinary Pharmacology and Therapeutics. 29 (Supplement 1), pp. 100-101. https://doi.org/10.1111/j.1365-2885.2006.00761.x
Article Title

In vitro effect of canine hyperimmune sera on TNFa activity

ERA Journal ID5533
Article CategoryArticle
AuthorsKotiw, Michael (Author), Shiels, I. A. (Author), Wilson, R. P. (Author) and Reeve-Johnson, Lloyd (Author)
Journal TitleJournal of Veterinary Pharmacology and Therapeutics
Journal Citation29 (Supplement 1), pp. 100-101
Number of Pages2
Year2006
Place of PublicationUnited Kingdom
ISSN0140-7783
Digital Object Identifier (DOI)https://doi.org/10.1111/j.1365-2885.2006.00761.x
Web Address (URL)http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2885.2006.00761.x
Abstract

[Introduction]: Septic shock in dogs is caused by cardiovascular and vasomotor failure associated with an uncontrolled intrinsic release of inflammatory mediators [1–5]. The syndrome is characterized by cardiovascular dysfunction, vascular permeability alterations,
pulmonary oedema and tissue hypoxia resulting from microthrombi which may culminate in disseminated intravascular coagulation and catastrophic multiple organ failure [6,7]. Systemic bacterial infection, particularly by Gram-negative enterobacteria, haemorrhagic trauma, gastric dilation/volvulus and pancreatitis are the major underlying causes leading tosepsis
[8,9]. Because of haemodynamic instability and associated hypovolemia, fluid replacement therapy is generally applied to restore effective circulating volume. The use of fresh frozen plasma has been recommended in cases of coagulopathies as it has been recognized to assist restoration of haemodynamic stability [1,5,10,11]. There is increasing evidence that the drivers of the
haemodynamic instability are inflammatory mediators (particularly TNFa) activated primarily by bacterial endotoxin [3,4,12,13].

Keywordsseptic shock; dogs
ANZSRC Field of Research 2020300904. Veterinary diagnosis and diagnostics
300999. Veterinary sciences not elsewhere classified
Public Notes

File reproduced in accordance with the copyright policy of the publisher/author.

Byline AffiliationsCentre for Systems Biology
University of Queensland
Plasvacc, Australia
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