In vitro and in vivo determination of ant-TNFa activity in canine plasma from donors subject to pre conditioning with endotoxin
Poster
Kotiw, Michael, Morgan, Michael, Lopez, Jesus, Taylor, Steven and Shiels, Ian. 2007. "In vitro and in vivo determination of ant-TNFa activity in canine plasma from donors subject to pre conditioning with endotoxin." Marshall, John (ed.) SEPSIS 2007: International Sepsis Forum ISF . Paris, France 26 - 29 Sep 2007 London, United Kingdom. https://doi.org/10.1186/cc6002
| Paper/Presentation Title | In vitro and in vivo determination of ant-TNFa activity in canine plasma from donors subject to pre conditioning with endotoxin |
|---|---|
| Presentation Type | Poster |
| Authors | Kotiw, Michael (Author), Morgan, Michael (Author), Lopez, Jesus (Author), Taylor, Steven (Author) and Shiels, Ian (Author) |
| Editors | Marshall, John |
| Journal or Proceedings Title | Critical Care |
| Critical Care (UK) | |
| Journal Citation | 11 (Supplement 4), pp. S11-S11 |
| Number of Pages | 1 |
| Year | 2007 |
| Place of Publication | London, United Kingdom |
| ISSN | 1364-8535 |
| 1466-609X | |
| Digital Object Identifier (DOI) | https://doi.org/10.1186/cc6002 |
| Web Address (URL) of Paper | http://ccforum.com/content/11/S4/P23 |
| Conference/Event | SEPSIS 2007: International Sepsis Forum ISF |
| Event Details | SEPSIS 2007: International Sepsis Forum ISF Event Date 26 to end of 29 Sep 2007 Event Location Paris, France |
| Abstract | Septic shock is characterized by cardiovascular and vasomotor failure that is induced by an uncontrolled cascade of inflammatory mediators such as TNFα, IL-1β and IL-6. In dogs, systemic bacterial infections, haemorrhage, trauma, gastric dilatation/volvulus and pancreatitis are the major causes of septic shock. While endotoxin is a recognized effector molecule that can initiate an inflammatory cascade, it has been reported that preconditioning with endotoxin can downregulate inflammatory cytokine responses to subsequent endotoxin challenge. This study reports the effect of endotoxin preconditioning on anti-TNFα activity present in plasma from canine donors. |
| Keywords | bacterial infections; endotoxin; plasma; blood donations; canines; dogs; inflamation; septic shock |
| ANZSRC Field of Research 2020 | 300999. Veterinary sciences not elsewhere classified |
| 310905. Animal immunology | |
| 310909. Animal physiology - cell | |
| Public Notes | Poster 23 |
| Byline Affiliations | Department of Biological and Physical Sciences |
| University of Queensland | |
| Centre for Systems Biology | |
| Institution of Origin | University of Southern Queensland |
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