In vitro and in vivo determination of ant-TNFa activity in canine plasma from donors subject to pre conditioning with endotoxin

Poster

Kotiw, Michael, Morgan, Michael, Lopez, Jesus, Taylor, Steven and Shiels, Ian. 2007. "In vitro and in vivo determination of ant-TNFa activity in canine plasma from donors subject to pre conditioning with endotoxin." Marshall, John (ed.) SEPSIS 2007: International Sepsis Forum ISF . Paris, France 26 - 29 Sep 2007 London, United Kingdom. https://doi.org/10.1186/cc6002
Paper/Presentation Title

In vitro and in vivo determination of ant-TNFa activity in canine plasma from donors subject to pre conditioning with endotoxin

Presentation TypePoster
AuthorsKotiw, Michael (Author), Morgan, Michael (Author), Lopez, Jesus (Author), Taylor, Steven (Author) and Shiels, Ian (Author)
EditorsMarshall, John
Journal or Proceedings TitleCritical Care
Critical Care (UK)
Journal Citation11 (Supplement 4), pp. S11-S11
Number of Pages1
Year2007
Place of PublicationLondon, United Kingdom
ISSN1364-8535
1466-609X
Digital Object Identifier (DOI)https://doi.org/10.1186/cc6002
Web Address (URL) of Paperhttp://ccforum.com/content/11/S4/P23
Conference/EventSEPSIS 2007: International Sepsis Forum ISF
Event Details
SEPSIS 2007: International Sepsis Forum ISF
Event Date
26 to end of 29 Sep 2007
Event Location
Paris, France
Abstract

Septic shock is characterized by cardiovascular and vasomotor failure that is induced by an uncontrolled cascade of inflammatory mediators such as TNFα, IL-1β and IL-6. In dogs, systemic bacterial infections, haemorrhage, trauma, gastric dilatation/volvulus and pancreatitis are the major causes of septic shock. While endotoxin is a recognized effector molecule that can initiate an inflammatory cascade, it has been reported that preconditioning with endotoxin can downregulate inflammatory cytokine responses to subsequent endotoxin challenge. This study reports the effect of endotoxin preconditioning on anti-TNFα activity present in plasma from canine donors.

Keywordsbacterial infections; endotoxin; plasma; blood donations; canines; dogs; inflamation; septic shock
ANZSRC Field of Research 2020300999. Veterinary sciences not elsewhere classified
310905. Animal immunology
310909. Animal physiology - cell
Public Notes

Poster 23

Byline AffiliationsDepartment of Biological and Physical Sciences
University of Queensland
Centre for Systems Biology
Institution of OriginUniversity of Southern Queensland
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