Caelestines A-D, Brominated Quinolinecarboxylic Acids from the Australian Ascidian Aplidium caelestis
Article
Article Title | Caelestines A-D, Brominated Quinolinecarboxylic Acids from the Australian Ascidian Aplidium caelestis |
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ERA Journal ID | 40471 |
Article Category | Article |
Authors | Yin, Sheng (Author), Boyle, Glen M. (Author), Carroll, Anthony R. (Author), Kotiw, Michael (Author), Dearnaley, John (Author), Quinn, Ronald J. (Author) and Davis, Rohan A. (Author) |
Journal Title | Journal of Natural Products |
Journal Citation | 73 (9), pp. 1586-1589 |
Number of Pages | 4 |
Year | 2010 |
Place of Publication | United States |
ISSN | 0163-3864 |
1520-6025 | |
Digital Object Identifier (DOI) | https://doi.org/10.1021/np100329w |
Web Address (URL) | https://pubs.acs.org/doi/10.1021/np100329w |
Abstract | Four new brominated natural products, caelestines A-D (1-4), have been isolated from the Australian ascidian Aplidium caelestis. The structures of 1-4 were determined by analysis of their NMR and MS data. This is the first report of brominated quinolinecarboxylic acids from nature. Compound 1 has been previously synthesized but not spectroscopically characterized. Compounds 1-4 were tested against three mammalian cell lines (MCF-7, NFF, and MM96L) and a panel of microbial strains and showed only minor cytotoxicity. |
Keywords | aplidium caelestis; quinolinecarboxylic acid; antibacterial activity; drug synthesis; high performance liquid chromatography; microorganism |
Contains Sensitive Content | Does not contain sensitive content |
ANZSRC Field of Research 2020 | 320701. Medical bacteriology |
340502. Natural products and bioactive compounds | |
320799. Medical microbiology not elsewhere classified | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Griffith University |
Queensland Institute of Medical Research, Australia | |
Department of Biological and Physical Sciences |
https://research.usq.edu.au/item/q0135/caelestines-a-d-brominated-quinolinecarboxylic-acids-from-the-australian-ascidian-aplidium-caelestis
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