Isochromophilone IX, a novel GABA-containing metabolite isolated from a cultured fungus, Penicillium sp.

Article


Michael, Adam P., Grace, Emily J., Kotiw, Michael and Barrow, Russell A.. 2003. "Isochromophilone IX, a novel GABA-containing metabolite isolated from a cultured fungus, Penicillium sp." Australian Journal of Chemistry: an international journal for chemical science. 56 (1), pp. 13-15. https://doi.org/10.1071/CH02021
Article Title

Isochromophilone IX, a novel GABA-containing metabolite isolated from a cultured fungus, Penicillium sp.

ERA Journal ID1314
Article CategoryArticle
AuthorsMichael, Adam P. (Author), Grace, Emily J. (Author), Kotiw, Michael (Author) and Barrow, Russell A. (Author)
Journal TitleAustralian Journal of Chemistry: an international journal for chemical science
Journal Citation56 (1), pp. 13-15
Number of Pages3
Year2003
Place of PublicationMelbourne, Australia
ISSN0004-9425
1445-0038
Digital Object Identifier (DOI)https://doi.org/10.1071/CH02021
Web Address (URL)http://www.publish.csiro.au/?act=view_file&file_id=CH02021.pdf
Abstract

Isochromophilone IX, a novel antibiotic active component was isolated from a penicillium species and investigated. Isochromophilone IX displays a specific rotation with the same sign as isochromophilone VI. It was found that isochromophilone represents the first occurrence of an γ-amino butyric acid (GABA) containing metabolite among only four naturally occuring members of this structure class.

Keywordsamino acids; fungi; high performance liquid chromatography; isomers; mass spectrometry; metabolites
ANZSRC Field of Research 2020310701. Bacteriology
349999. Other chemical sciences not elsewhere classified
320501. Medical biochemistry - amino acids and metabolites
320603. Medical molecular engineering of nucleic acids and proteins
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Byline AffiliationsAustralian National University
Department of Biological and Physical Sciences
Institution of OriginUniversity of Southern Queensland
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