Review of anti-inflammatory, immune-modulatory and wound healing properties of molluscs

Article


Ahmad, Tarek B., Liu, Lei, Kotiw, Michael and Benkendorff, Kirsten. 2018. "Review of anti-inflammatory, immune-modulatory and wound healing properties of molluscs." Journal of Ethnopharmacology. 210, pp. 156-178. https://doi.org/10.1016/j.jep.2017.08.008
Article Title

Review of anti-inflammatory, immune-modulatory and wound healing properties of molluscs

ERA Journal ID2603
Article CategoryArticle
AuthorsAhmad, Tarek B. (Author), Liu, Lei (Author), Kotiw, Michael (Author) and Benkendorff, Kirsten (Author)
Journal TitleJournal of Ethnopharmacology
Journal Citation210, pp. 156-178
Number of Pages23
Year2018
Place of PublicationIreland
ISSN0378-8741
1872-7573
Digital Object Identifier (DOI)https://doi.org/10.1016/j.jep.2017.08.008
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S0378874117317178
Abstract

Ethnopharmacological relevance: This review focuses on traditional and contemporary anti-inflammatory uses of mollusc-derived products summarizing all the in vitro and human clinical trials that have tested the anti-inflammatory activity of molluscan natural products. Inflammatory conditions, burns and wounds have been an ongoing concern for human health since the early era of civilisation. Many texts from ancient medicine have recorded the symptoms, signs and treatments for these conditions. Natural treatments are well documented in traditional European medicine, Traditional Chinese Medicine (TCM), siddha and ancient Mediterranean and African traditional medicine and include a surprisingly large number of molluscan species. Materials and methods: An extensive review of the Materia Medica and scientific literature was undertaken using key word searches for 'mollusk' and 'anti-inflammatory' or 'immunomodulatory' or 'wound healing'. Results: Molluscs have been used in ethnomedicine by many traditional cultures to treat different aspects of inflammatory conditions. We found 104 different anti-inflammatory preparations from a variety of molluscan species, of which 70 were from the well-documented Traditional Chinese Medicine (TCM). This traditional use of molluscs has driven the testing for anti-inflammatory activity in extracts from some species in the phylum Mollusca, with 20 in vitro studies, 40 in vivo animal studies and 14 human clinical trials performed to substantiate the anti-inflammatory and wound healing of molluscs. Some of these studies have led to the approval of mollusk-derived products to be used as over-the-counter (OTC) nutriceuticals, like Lyprinol® and Biolane™ from the New Zealand green lipped mussel Perna canaliculus. Conclusion: Natural products provide important leads for the development of pharmaceuticals, including anti-inflammatory agents. Only a small proportion of the molluscan traditional medicines have been tested to confirm their anti-inflammatory activity and most screening studies have tested crude extracts from molluscs without any chemical characterisation. This highlights the need for further research to strategically identify the anti-inflammatory compounds in molluscan medicines to provide leads for novel anti-inflammatory drugs in the future.

KeywordsMarine natural products, Mollusca, Shells, TCM, Traditional Chinese Medicine, Materia Medica, Lyprinol, Inflammation, Wound healing
ANZSRC Field of Research 2020420899. Traditional, complementary and integrative medicine not elsewhere classified
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Byline AffiliationsSouthern Cross University
Centre for Health Sciences Research
Institution of OriginUniversity of Southern Queensland
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