L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats
Article
Article Title | L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats |
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ERA Journal ID | 14581 |
Article Category | Article |
Authors | Fenning, Andrew (Author), Harrison, Glenn (Author), Rose'Meyer, Roselyn (Author), Hoey, Andrew (Author) and Brown, Lindsay (Author) |
Journal Title | American Journal of Physiology: Heart and Circulatory Physiology |
Journal Citation | 289 (4), pp. H1408-H1416 |
Number of Pages | 9 |
Year | 2005 |
Place of Publication | USA |
ISSN | 0363-6135 |
1522-1539 | |
Digital Object Identifier (DOI) | https://doi.org/10.1152/ajpheart.00140.2005 |
Web Address (URL) | http://ajpheart.physiology.org/cgi/reprint/289/4/H1408?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=hoey&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT |
Abstract | Nitric oxide (NO) is essential for normal function of the cardiovascular system. This study has determined whether chronic administration of L-arginine, the biological precursor of NO, attenuates the development of structural and functional changes in hearts and blood vessels of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Uninephrectomized rats treated with DOCA (25 mg every 4th day sc) and 1% NaCl in the drinking water for 4 wk were treated with L-arginine (5% in food, 3.4 plus/minus 0.3 g per kg body wt-1 per day-1). Changes in cardiovascular structure and function were determined by echocardiography, microelectrode studies, histology, and studies in isolated hearts and thoracic aortic rings. DOCA-salt hypertensive rats developed hypertension, left ventricular hypertrophy with increased left ventricular wall thickness and decreased ventricular internal diameter, increased inflammatory cell infiltration, increased ventricular interstitial and perivascular collagen deposition, increased passive diastolic stiffness, prolonged action potential duration, increased oxidative stress, and inability to increase purine efflux in response to an increased workload. L-Arginine markedly attenuated or prevented these changes and also normalized the reduced efficacy of norepinephrine and acetylcholine in isolated thoracic aortic rings of DOCA-salt hypertensive rats. This study suggests that a functional NO deficit in blood vessels and heart due to decreased NO synthase activity or increased release of reactive oxygen species such as superoxide may be a key change initiating many aspects of the cardiovascular impairment observed in DOCA-salt hypertensive rats. These changes can be prevented or attenuated by administration of L-arginine. |
Keywords | eoxycorticosterone acetate; oxidative stress; remodeling; collagen |
ANZSRC Field of Research 2020 | 320803. Systems physiology |
320101. Cardiology (incl. cardiovascular diseases) | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Office of Research |
Griffith University | |
Department of Biological and Physical Sciences |
https://research.usq.edu.au/item/9x8yw/l-arginine-attenuates-cardiovascular-impairment-in-doca-salt-hypertensive-rats
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