Stearoyl-CoA desaturase: a vital checkpoint in the development and progression of obesity
Article
Article Title | Stearoyl-CoA desaturase: a vital checkpoint in the development and progression of obesity |
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ERA Journal ID | 200424 |
Article Category | Article |
Authors | Poudyal, Hemant (Author) and Brown, Lindsay (Author) |
Journal Title | Endocrine, Metabolic and Immune Disorders: Drug Targets |
Journal Citation | 11 (3), pp. 217-231 |
Number of Pages | 15 |
Year | 2011 |
Place of Publication | Bussum, Netherlands |
ISSN | 1871-5303 |
2212-3873 | |
Web Address (URL) | http://www.benthamscience.com/contents-JCode-EMIDDT-Vol-00000011-Iss-00000003.htm |
Abstract | Stearoyl-CoA desaturase 1 (SCD-1) is the rate-limiting enzyme that catalyses the conversion of saturated to monounsaturated fatty acids. Increased SCD-1 expression and activity has been implicated in cancer, cardiovascular diseases, insulin resistance and obesity. Studies with humans, wild-type rodents, knock-out mice and cells in culture show that SCD-1 inhibition decreases lipogenesis and increases GLUT4-mediated glucose uptake in skeletal muscle. In this review, we will evaluate the role of SCD-1 as a homeostatic check-point between glucose and fatty acid metabolism in the development and progression of obesity. In addition to the role of SCD-1 in glucose and fatty acid metabolism, we will also discuss the expression and regulation of SCD-1, its specific interactions with inflammatory responses and PPARs, the role of SCD-1 derived MUFAs in obesity and the relevance of SCD desaturation index as a predictor of obesity and metabolic syndrome. Additionally, we will explore the prospects of SCD-1 as a potential drug target for the management of obesity and related disorders. |
Keywords | stearoyl-CoA desaturase; SCD-1; metabolic syndrome; PPAR; desaturation index; MUFA; obesity; catalyses; fatty acids; insulin resistance; lipogenesis; skeletal muscle; glucose |
ANZSRC Field of Research 2020 | 310999. Zoology not elsewhere classified |
321004. Nutritional science | |
320504. Medical biochemistry - lipids | |
Public Notes | Permanent restricted access to published version due to publisher copyright policy. |
Byline Affiliations | University of Queensland |
Department of Biological and Physical Sciences | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q0ywz/stearoyl-coa-desaturase-a-vital-checkpoint-in-the-development-and-progression-of-obesity
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