Capsaicin in metabolic syndrome
Article
Article Title | Capsaicin in metabolic syndrome |
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ERA Journal ID | 211152 |
Article Category | Article |
Authors | Panchal, Sunil K. (Author), Bliss, Edward (Author) and Brown, Lindsay (Author) |
Journal Title | Nutrients |
Journal Citation | 10 (5), pp. 1-21 |
Article Number | 630 |
Number of Pages | 21 |
Year | 2018 |
Publisher | MDPI AG |
Place of Publication | Switzerland |
ISSN | 2072-6643 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/nu10050630 |
Web Address (URL) | http://www.mdpi.com/2072-6643/10/5/630 |
Abstract | Capsaicin, the major active constituent of chilli, is an agonist on transient receptor potential vanilloid channel 1 (TRPV1). TRPV1 is present on many metabolically active tissues, making it a potentially relevant target for metabolic interventions. Insulin resistance and obesity, being the major components of metabolic syndrome, increase the risk for the development of cardiovascular disease, type 2 diabetes, and non-alcoholic fatty liver disease. In vitro and pre-clinical studies have established the effectiveness of low-dose dietary capsaicin in attenuating metabolic disorders. These responses of capsaicin are mediated through activation of TRPV1, which can then modulate processes such as browning of adipocytes, and activation of metabolic modulators including AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor alpha (PPARalpha), uncoupling protein 1 (UCP1), and glucagon-like peptide 1 (GLP-1). Modulation of these pathways by capsaicin can increase fat oxidation, improve insulin sensitivity, decrease body fat, and improve heart and liver function. Identifying suitable ways of administering capsaicin at an effective dose would warrant its clinical use through the activation of TRPV1. This review highlights the mechanistic options to improve metabolic syndrome with capsaicin. |
Keywords | capsaicin; metabolic syndrome; transient receptor potential vanilloid channel 1; TRPV1; obesity; insulin resistance; diabetes; non-alcoholic fatty liver disease |
ANZSRC Field of Research 2020 | 321004. Nutritional science |
321401. Basic pharmacology | |
Byline Affiliations | Functional Foods Research Group |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q4x5z/capsaicin-in-metabolic-syndrome
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Capsaicin in Metabolic Syndrome review.pdf | ||
License: CC BY 4.0 | ||
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