Capsaicin: A Potential Treatment to Improve Cerebrovascular Function and Cognition in Obesity and Ageing

Article


Thornton, Tammy, Mills, Dean and Bliss, Edward. 2023. "Capsaicin: A Potential Treatment to Improve Cerebrovascular Function and Cognition in Obesity and Ageing ." Nutrients. 15 (6). https://doi.org/10.3390/nu15061537
Article Title

Capsaicin: A Potential Treatment to Improve Cerebrovascular Function and Cognition in Obesity and Ageing

ERA Journal ID211152
Article CategoryArticle
AuthorsThornton, Tammy, Mills, Dean and Bliss, Edward
Journal TitleNutrients
Journal Citation15 (6)
Article Number1537
Number of Pages24
YearMar 2023
PublisherMDPI AG
Place of PublicationSwitzerland
ISSN2072-6643
Digital Object Identifier (DOI)https://doi.org/10.3390/nu15061537
Web Address (URL)https://www.mdpi.com/2072-6643/15/6/1537
Abstract

Impaired cognition is the primary symptom of dementia, which can lead to functional disability and reduced quality of life among an increasingly ageing population. Ageing is associated with increased oxidative stress, chronic low-grade systemic inflammation, and endothelial dysfunction, which reduces cerebrovascular function leading to cognitive decline. Chronic low-grade systemic inflammatory conditions, such as obesity, exacerbate this decline beyond normal ageing and predispose individuals to neurodegenerative diseases, such as dementia. Capsaicin, the major pungent molecule of chilli, has recently demonstrated improvements in cognition in animal models via activation of the transient receptor potential vanilloid channel 1 (TRPV1). Capsaicin-induced TRPV1 activation reduces adiposity, chronic low-grade systemic inflammation, and oxidative stress, as well as improves endothelial function, all of which are associated with cerebrovascular function and cognition. This review examines the current literature on capsaicin and Capsimax, a capsaicin supplement associated with reduced gastrointestinal irritation compared to capsaicin. Acute and chronic capsaicin treatment can improve cognition in animals. However, studies adequately assessing the effects of capsaicin on cerebrovascular function, and cognition in humans do not exist. Capsimax may be a potentially safe therapeutic intervention for future clinical trials testing the effects of capsaicin on cerebrovascular function and cognition.

Keywordscapsaicin; cerebrovascular; cognition; obesity; ageing
Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020320199. Cardiovascular medicine and haematology not elsewhere classified
320999. Neurosciences not elsewhere classified
321099. Nutrition and dietetics not elsewhere classified
Byline AffiliationsSchool of Health and Medical Sciences
Centre for Health Research
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