Capsaicin: A Potential Treatment to Improve Cerebrovascular Function and Cognition in Obesity and Ageing
Article
Thornton, Tammy, Mills, Dean and Bliss, Edward. 2023. "Capsaicin: A Potential Treatment to Improve Cerebrovascular Function and Cognition in Obesity and Ageing
." Nutrients. 15 (6). https://doi.org/10.3390/nu15061537
| Article Title | Capsaicin: A Potential Treatment to Improve Cerebrovascular Function and Cognition in Obesity and Ageing |
|---|---|
| ERA Journal ID | 211152 |
| Article Category | Article |
| Authors | Thornton, Tammy, Mills, Dean and Bliss, Edward |
| Journal Title | Nutrients |
| Journal Citation | 15 (6) |
| Article Number | 1537 |
| Number of Pages | 24 |
| Year | Mar 2023 |
| Publisher | MDPI AG |
| Place of Publication | Switzerland |
| ISSN | 2072-6643 |
| Digital Object Identifier (DOI) | https://doi.org/10.3390/nu15061537 |
| Web Address (URL) | https://www.mdpi.com/2072-6643/15/6/1537 |
| Abstract | Impaired cognition is the primary symptom of dementia, which can lead to functional disability and reduced quality of life among an increasingly ageing population. Ageing is associated with increased oxidative stress, chronic low-grade systemic inflammation, and endothelial dysfunction, which reduces cerebrovascular function leading to cognitive decline. Chronic low-grade systemic inflammatory conditions, such as obesity, exacerbate this decline beyond normal ageing and predispose individuals to neurodegenerative diseases, such as dementia. Capsaicin, the major pungent molecule of chilli, has recently demonstrated improvements in cognition in animal models via activation of the transient receptor potential vanilloid channel 1 (TRPV1). Capsaicin-induced TRPV1 activation reduces adiposity, chronic low-grade systemic inflammation, and oxidative stress, as well as improves endothelial function, all of which are associated with cerebrovascular function and cognition. This review examines the current literature on capsaicin and Capsimax, a capsaicin supplement associated with reduced gastrointestinal irritation compared to capsaicin. Acute and chronic capsaicin treatment can improve cognition in animals. However, studies adequately assessing the effects of capsaicin on cerebrovascular function, and cognition in humans do not exist. Capsimax may be a potentially safe therapeutic intervention for future clinical trials testing the effects of capsaicin on cerebrovascular function and cognition. |
| Keywords | capsaicin; cerebrovascular; cognition; obesity; ageing |
| Contains Sensitive Content | Does not contain sensitive content |
| ANZSRC Field of Research 2020 | 320199. Cardiovascular medicine and haematology not elsewhere classified |
| 320999. Neurosciences not elsewhere classified | |
| 321099. Nutrition and dietetics not elsewhere classified | |
| Byline Affiliations | School of Health and Medical Sciences |
| Centre for Health Research |
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