The acute effects of endurance exercise on epithelial integrity of the airways in athletes and non-athletes: A systematic review and meta-analysis

Article

Pourmanaf, Hadi, Nikoukheslat, Saeid, Sari-Sarraf, Vahid, Amirsasan, Ramin, Vakili, Javad and Mills, Dean E.. 2023. "The acute effects of endurance exercise on epithelial integrity of the airways in athletes and non-athletes: A systematic review and meta-analysis." Respiratory Medicine. 220. https://doi.org/10.1016/j.rmed.2023.107457
Article Title

The acute effects of endurance exercise on epithelial integrity of the airways in athletes and non-athletes: A systematic review and meta-analysis

ERA Journal ID16812
Article CategoryArticle
AuthorsPourmanaf, Hadi, Nikoukheslat, Saeid, Sari-Sarraf, Vahid, Amirsasan, Ramin, Vakili, Javad and Mills, Dean E.
Journal TitleRespiratory Medicine
Journal Citation220
Article Number107457
Number of Pages10
Year2023
PublisherElsevier
ISSN0954-6111
1532-3064
Digital Object Identifier (DOI)https://doi.org/10.1016/j.rmed.2023.107457
Web Address (URL)https://www.resmedjournal.com/article/S0954-6111(23)00345-1/fulltext
Abstract

Introduction
Acute endurance exercise may induce airway epithelium injury. However, the response of epithelial integrity markers of the airways including club cell secretory protein (CC16) and surfactant protein D (SP-D) to endurance exercise have not been systematically reviewed. Therefore, the aim of this systematic review and meta-analysis was to assess the acute effects of endurance exercise on markers of epithelial integrity of the airways (CC16, SP-D and the CC16/SP-D ratio) in athletes and non-athletes.
Methods
A systematic search was performed utilizing PubMed/Medline, EMBASE, Web of Science, and hand searching bibliographies of retrieved articles through to September 2022. Based on the inclusion criteria, articles with available data about the acute effects of endurance exercise on serum or plasma concentrations of CC16, SP-D and CC16/SP-D ratio in athletes and non-athletes were included. Quality assessment of studies and statistical analysis were conducted via Review Manager 5.4 software.
Results
The search resulted in 908 publications. Finally, thirteen articles were included in the review. Acute endurance exercise resulted in an increase in CC16 (P = 0.0006, n = 13) and CC16/SP-D ratio (P = 0.005, n = 2) whereas SP-D (P = 0.47, n = 3) did not change significantly. Subgroup analysis revealed that the type (P = 0.003), but not the duration of exercise (P = 0.77) or the environmental temperature (P = 0.06) affected the CC16 response to endurance exercise.
Conclusions
Acute endurance exercise increases CC16 and the CC16/SP-D ratio, as markers of epithelial integrity, but not SP-D in athletes and non-athletes.

Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020420799. Sports science and exercise not elsewhere classified
Byline AffiliationsUniversity of Tabriz, Iran
School of Health and Medical Sciences
Centre for Health Research
Institute for Resilient Regions
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