The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study

Article


Mallard, Alistair, Briskey, David, Richards, Andrew, Mills, Dean and Rao, Amanda. 2020. "The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study." Nutrients. 12 (3), pp. 1-13. https://doi.org/10.3390/nu12030596
Article Title

The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study

ERA Journal ID211152
Article CategoryArticle
AuthorsMallard, Alistair (Author), Briskey, David (Author), Richards, Andrew (Author), Mills, Dean (Author) and Rao, Amanda (Author)
Journal TitleNutrients
Journal Citation12 (3), pp. 1-13
Article Number596
Number of Pages13
Year2020
PublisherMDPI AG
Place of PublicationSwitzerland
ISSN2072-6643
Digital Object Identifier (DOI)https://doi.org/10.3390/nu12030596
Web Address (URL)https://www.mdpi.com/2072-6643/12/3/596
Abstract

The aim of this study was to evaluate the effect of palmitoylethanolamide (PEA), a cannabimimetic compound and lipid messenger, on recovery from muscle damaging exercise. Twenty-eight healthy young male participants attended the laboratory four times on subsequent days. In the first visit, baseline characteristics were recorded before participants were randomized to consume either liquid PEA (167.5 mg Levagen+ with 832.5 mg maltodextrin) or a matched placebo (1 g maltodextrin) drink. Leg press exercise consisted of four sets at 80% of one repetition maximum followed by a performance set. Muscle soreness, thigh circumference, blood lactate concentration, biomarkers of muscle damage and inflammation, and transcription factor pathways were measured pre- and immediately post-exercise and again at 1, 2, 3, 24, 48, and 72 h post-exercise. The leg press exercise increased (p < 0.05) blood lactate concentration and induced muscle damage as evidenced by increased muscle soreness, thigh circumference, biomarkers of muscle damage, and concentrations of tumor necrosis factor-α. PEA reduced (p < 0.05) myoglobin and blood lactate concentrations and increased protein kinase B phosphorylation following exercise. Taken together, these results indicate PEA supplementation may aid in muscle recovery from repeat bouts of exercise performed within a short duration by reducing myoglobin and lactate concentration.

Keywordspalmitoylethanolamide; recovery; leg press exercise; muscle damage; functional foods
ANZSRC Field of Research 2020321099. Nutrition and dietetics not elsewhere classified
420702. Exercise physiology
Byline AffiliationsUniversity of Queensland
RDC Clinical, Australia
Centre for Health, Informatics and Economic Research
University of Sydney
Institution of OriginUniversity of Southern Queensland
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