The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study
Article
Mallard, Alistair, Briskey, David, Richards, Andrew, Mills, Dean and Rao, Amanda. 2020. "The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study." Nutrients. 12 (3), pp. 1-13. https://doi.org/10.3390/nu12030596
| Article Title | The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study |
|---|---|
| ERA Journal ID | 211152 |
| Article Category | Article |
| Authors | Mallard, Alistair (Author), Briskey, David (Author), Richards, Andrew (Author), Mills, Dean (Author) and Rao, Amanda (Author) |
| Journal Title | Nutrients |
| Journal Citation | 12 (3), pp. 1-13 |
| Article Number | 596 |
| Number of Pages | 13 |
| Year | 2020 |
| Publisher | MDPI AG |
| Place of Publication | Switzerland |
| ISSN | 2072-6643 |
| Digital Object Identifier (DOI) | https://doi.org/10.3390/nu12030596 |
| Web Address (URL) | https://www.mdpi.com/2072-6643/12/3/596 |
| Abstract | The aim of this study was to evaluate the effect of palmitoylethanolamide (PEA), a cannabimimetic compound and lipid messenger, on recovery from muscle damaging exercise. Twenty-eight healthy young male participants attended the laboratory four times on subsequent days. In the first visit, baseline characteristics were recorded before participants were randomized to consume either liquid PEA (167.5 mg Levagen+ with 832.5 mg maltodextrin) or a matched placebo (1 g maltodextrin) drink. Leg press exercise consisted of four sets at 80% of one repetition maximum followed by a performance set. Muscle soreness, thigh circumference, blood lactate concentration, biomarkers of muscle damage and inflammation, and transcription factor pathways were measured pre- and immediately post-exercise and again at 1, 2, 3, 24, 48, and 72 h post-exercise. The leg press exercise increased (p < 0.05) blood lactate concentration and induced muscle damage as evidenced by increased muscle soreness, thigh circumference, biomarkers of muscle damage, and concentrations of tumor necrosis factor-α. PEA reduced (p < 0.05) myoglobin and blood lactate concentrations and increased protein kinase B phosphorylation following exercise. Taken together, these results indicate PEA supplementation may aid in muscle recovery from repeat bouts of exercise performed within a short duration by reducing myoglobin and lactate concentration. |
| Keywords | palmitoylethanolamide; recovery; leg press exercise; muscle damage; functional foods |
| ANZSRC Field of Research 2020 | 321099. Nutrition and dietetics not elsewhere classified |
| 420702. Exercise physiology | |
| Byline Affiliations | University of Queensland |
| RDC Clinical, Australia | |
| Centre for Health, Informatics and Economic Research | |
| University of Sydney | |
| Institution of Origin | University of Southern Queensland |
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