Influence of a specialized Trigonella foenum-graecum seed extract (Libifem), on testosterone, estradiol and sexual function in healthy menstruating women, a randomised placebo controlled study

Article

Rao, Amanda, Steels, Elizabeth, Beccaria, Gavin, Inder, Warrick and Vitetta, Luis. 2015. "Influence of a specialized Trigonella foenum-graecum seed extract (Libifem), on testosterone, estradiol and sexual function in healthy menstruating women, a randomised placebo controlled study." Phytotherapy Research. 29 (8), pp. 1123-1130. https://doi.org/10.1002/ptr.5355
Article Title

Influence of a specialized Trigonella foenum-graecum seed extract (Libifem), on testosterone, estradiol and sexual function in healthy menstruating women, a randomised placebo controlled study

ERA Journal ID14852
Article CategoryArticle
AuthorsRao, Amanda (Author), Steels, Elizabeth (Author), Beccaria, Gavin (Author), Inder, Warrick (Author) and Vitetta, Luis (Author)
Journal TitlePhytotherapy Research
Journal Citation29 (8), pp. 1123-1130
Number of Pages8
Year2015
Place of PublicationUnited Kingdom
ISSN0951-418X
1099-1573
Digital Object Identifier (DOI)https://doi.org/10.1002/ptr.5355
Web Address (URL)http://onlinelibrary.wiley.com/doi/10.1002/ptr.5355/full
Abstract

The aim of the study was to evaluate the effect of Trigonella foenum-graecum (fenugreek) seed extract on sex hormones and sexual function in healthy menstruating women who reported low sexual drive. This short term, single site, double blind, randomised, placebo-controlled study was conducted on 80 women, aged 20 to 49 years. Participants were randomised to either an oral dose of a standardised T. foenum-graecum seed extract (libifem) at a dose of 600 mg/day or placebo over two menstrual cycles. Dehydroepiandrosterone sulfate, progesterone, androstenedione, total and free testosterone, estradiol (E2), luteinizing hormone, follicle stimulating hormone, sex hormone binding globulin and cholesterol were measured at baseline and 8 weeks. The individual aspects of sexual function were measured using the Derogatis interview for sexual functioning and female sexual function index self-administered questionnaires. Stress, fatigue and quality of the relationship with partner were also measured using the PSS (Perceived Stress Scale), MFI-20 (Multidimensional Fatigue Inventory) and DAS (Dyadic Adjustment Scale) quality of life measures, respectively. There was a significant increase in free testosterone and E2 in the active group as well as sexual desire and arousal compared with the placebo group. The results indicate that this extract of T. foenum-graecum may be a useful treatment for increasing sexual arousal and desire in women. Copyright © 2015 John Wiley & Sons, Ltd.

KeywordsTrigonella  foenum-graecum; fenugreek; oestrogen; estradiol; testosterone; sexual desire; sexual function
Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020420802. Naturopathy
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Byline AffiliationsUniversity of Sydney
Integrated Health Group, Australia
School of Psychology and Counselling
University of Queensland
Institution of OriginUniversity of Southern Queensland
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