The Effects of Aerobic Exercise Training on Cerebrovascular and Cognitive Function in Sedentary, Obese, Older Adults
Article
Article Title | The Effects of Aerobic Exercise Training on Cerebrovascular and Cognitive Function in Sedentary, Obese, Older Adults |
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ERA Journal ID | 200509 |
Article Category | Article |
Authors | Bliss, Edward S. (Author), Wong, Rachel W. X. (Author), Howe, Peter R. C. (Author) and Mills, Dean E. (Author) |
Journal Title | Frontiers in Aging Neuroscience |
Journal Citation | 14, pp. 1-15 |
Article Number | 892343 |
Number of Pages | 15 |
Year | 2022 |
Place of Publication | Switzerland |
ISSN | 1663-4365 |
Digital Object Identifier (DOI) | https://doi.org/10.3389/fnagi.2022.892343 |
Web Address (URL) | https://www.frontiersin.org/articles/10.3389/fnagi.2022.892343/full |
Abstract | Cerebrovascular function and cognition decline with age and are further exacerbated by obesity and physical inactivity. This decline may be offset by aerobic exercise training (AT). We investigated the effects of 16 weeks AT on cerebrovascular and cognitive function in sedentary, obese, older adults. Twenty-eight participants were randomly allocated to AT or a control group. Before and after the intervention, transcranial Doppler ultrasonography was used to measure the cerebrovascular responsiveness (CVR) to physiological (hypercapnia, 5% carbon dioxide) and cognitive stimuli. AT increased the CVR to hypercapnia (98.5 ± 38.4% vs. 58.0 ± 42.0%, P = 0.021), CVR to cognitive stimuli (25.9 ± 6.1% vs. 16.4 ± 5.4%, P < 0.001) and total composite cognitive score (111 ± 14 vs. 104 ± 14, P = 0.004) compared with the control group. A very strong relationship was observed between the number of exercise sessions completed and CVR to cognitive stimuli (r = 0.878, P < 0.001), but not for CVR to hypercapnia (r = 0.246, P = 0.397) or total composite cognitive score (r = 0.213, P = 0.465). Cerebrovascular function and cognition improved following 16 weeks of AT and a dose-response relationship exists between the amount of exercise sessions performed and CVR to cognitive stimuli. |
Keywords | aerobic exercise training, cerebrovascular function, cognition, aging, obesity |
Related Output | |
Is part of | The effect of aerobic exercise on cerebrovascular function and cognition in older adults |
ANZSRC Field of Research 2020 | 320899. Medical physiology not elsewhere classified |
420799. Sports science and exercise not elsewhere classified | |
320199. Cardiovascular medicine and haematology not elsewhere classified | |
320999. Neurosciences not elsewhere classified | |
Institution of Origin | University of Southern Queensland |
Byline Affiliations | School of Health and Medical Sciences |
Centre for Health Research (Operations) | |
University of Newcastle | |
Centre for Health Research |
https://research.usq.edu.au/item/q75yq/the-effects-of-aerobic-exercise-training-on-cerebrovascular-and-cognitive-function-in-sedentary-obese-older-adults
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