Evidence for circulatory benefits of Resveratrol in humans

Article

Wong, Rachel H. X., Coates, Alison M., Buckley, Jonathan D. and Howe, Peter R. C.. 2013. "Evidence for circulatory benefits of Resveratrol in humans." Annals of the New York Academy of Sciences. 1290 (1), pp. 52-58. https://doi.org/10.1111/nyas.12155
Article Title

Evidence for circulatory benefits of Resveratrol in humans

ERA Journal ID11271
Article CategoryArticle
AuthorsWong, Rachel H. X. (Author), Coates, Alison M. (Author), Buckley, Jonathan D. (Author) and Howe, Peter R. C. (Author)
Journal TitleAnnals of the New York Academy of Sciences
Journal Citation1290 (1), pp. 52-58
Number of Pages7
Year2013
Place of PublicationUnited States
ISSN0077-8923
1749-6632
Digital Object Identifier (DOI)https://doi.org/10.1111/nyas.12155
Web Address (URL)http://onlinelibrary.wiley.com/doi/10.1111/nyas.12155/abstract
Abstract

Impairments of endothelial function, which can be assessed noninvasively by flow-mediated dilation (FMD) of the brachial artery, contribute to the development of cardiovascular disease. Associations between FMD and cognition suggest a vascular component in the loss of cognitive function. Certain vasoactive nutrients that have been shown to improve FMD may also have the potential to enhance cerebral perfusion and cognition. Preclinical studies show that trans-resveratrol can enhance nitric oxide bioavailability, thereby increasing endothelium-dependent vasodilation. We have now shown that acute administration of resveratrol elicits dose-dependent increases of FMD with greater potency than other vasoactive nutrients and that this benefit is sustained following regular consumption. We describe the potential implications of this vasodilator benefit of resveratrol and its role in enhancing cerebrovascular and cognitive functions.

KeywordsEndothelial function; Flow-mediated dilation; Human; Resveratrol; trans-resveratrol; Vasodilator responsiveness; Cardiovascular Diseases and Cardiovascular Surgery; Clinical and Experimental Pharmacology
ANZSRC Field of Research 2020320199. Cardiovascular medicine and haematology not elsewhere classified
Public Notes

Files associated with this item cannot be displayed due to copyright restrictions.

Byline AffiliationsUniversity of South Australia
Institution of OriginUniversity of Southern Queensland
Permalink -

https://research.usq.edu.au/item/q40zy/evidence-for-circulatory-benefits-of-resveratrol-in-humans

Log in to edit
  • 1202
    total views
  • 8
    total downloads
  • 3
    views this month
  • 0
    downloads this month

Export as

Related outputs

Associations between Cerebrovascular Function and the Expression of Genes Related to Endothelial Function in Hormonal Migraine
Dzator, Jemima S. A., Smith, Robert A., Coupland, Kirsten G., Howe, Peter R. C. and Griffiths, Lyn R.. 2024. "Associations between Cerebrovascular Function and the Expression of Genes Related to Endothelial Function in Hormonal Migraine." International Journal of Molecular Sciences. 25 (3). https://doi.org/10.3390/ijms25031694
Resveratrol-Induced Suppression of C-type Natriuretic Peptide Associates With Increased Vertebral Bone Density in Postmenopausal Women
Prickett, Timothy CR, Howe, Peter RC and Espiner, Eric A. 2023. "Resveratrol-Induced Suppression of C-type Natriuretic Peptide Associates With Increased Vertebral Bone Density in Postmenopausal Women." JBMR Plus. 7 (5). https://doi.org/10.1002/jbm4.10732
Exploring the effects of resveratrol supplementation on cerebrovascular function in hormonal migraineurs: A pilot study
Dzator, Jemima S.A., Coupland, Kirsten G. and Howe, Peter R.C.. 2023. "Exploring the effects of resveratrol supplementation on cerebrovascular function in hormonal migraineurs: A pilot study." IBRO Neuroscience Reports. 15, pp. 310-319. https://doi.org/10.1016/j.ibneur.2023.10.005
The benefits of regular aerobic exercise training on cerebrovascular function and cognition in older adults
Bliss, Edward S., Biki, Samia M., Wong, Rachel H. X., Howe, Peter R. C. and Mills, Dean E.. 2023. "The benefits of regular aerobic exercise training on cerebrovascular function and cognition in older adults." European Journal of Applied Physiology. 123 (6), pp. 1323-1342. https://doi.org/10.1007/s00421-023-05154-y
The Effects of Aerobic Exercise Training on Cerebrovascular and Cognitive Function in Sedentary, Obese, Older Adults
Bliss, Edward S., Wong, Rachel W. X., Howe, Peter R. C. and Mills, Dean E.. 2022. "The Effects of Aerobic Exercise Training on Cerebrovascular and Cognitive Function in Sedentary, Obese, Older Adults." Frontiers in Aging Neuroscience. 14, pp. 1-15. https://doi.org/10.3389/fnagi.2022.892343
Long-term resveratrol supplementation improves pain perception, menopausal symptoms, and overall well-being in postmenopausal women: findings from a 24-month randomized, controlled, crossover trial
Zaw, Jay Jay Thaung, Howe, Peter R .C. and Wong, Rachel H. X.. 2021. "Long-term resveratrol supplementation improves pain perception, menopausal symptoms, and overall well-being in postmenopausal women: findings from a 24-month randomized, controlled, crossover trial." Menopause. 28 (1), pp. 40-49. https://doi.org/10.1097/GME.0000000000001643
Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial
Kuszewski, Julia C., Wong, Rachel H. X., Wood, Lisa G. and Howe, Peter R. C.. 2020. "Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial." Nutrition Metabolism and Cardiovascular Diseases. 30 (4), pp. 625-633. https://doi.org/10.1016/j.numecd.2019.12.010
Profiling cerebrovascular function in migraine: A systematic review and meta-analysis
Dzator, Jemima S. A ., Howe, Peter R. C. and Wong, Rachel H. X.. 2021. "Profiling cerebrovascular function in migraine: A systematic review and meta-analysis." Journal of Cerebral Blood Flow and Metabolism. 41 (5), pp. 919-944. https://doi.org/10.1177/0271678X20964344
Does phytoestrogen supplementation improve cognition in humans? A systematic review
Zaw, Jay Jay Thaung, Howe, Peter Ranald Charles and Wong, Rachel Heloise Xiwen. 2017. "Does phytoestrogen supplementation improve cognition in humans? A systematic review." Annals of the New York Academy of Sciences. 1403 (1), pp. 150-163. https://doi.org/10.1111/nyas.13459
Long Chain Omega-3 Polyunsaturated Fatty Acid Supplementation Protects Against Adriamycin and Cyclophosphamide Chemotherapy-Induced Bone Marrow Damage in Female Rats
Fan, Chia-Ming, Su, Yu-Wen, Howe, Peter R. and Xian, Cory J.. 2018. "Long Chain Omega-3 Polyunsaturated Fatty Acid Supplementation Protects Against Adriamycin and Cyclophosphamide Chemotherapy-Induced Bone Marrow Damage in Female Rats." International Journal of Molecular Sciences. 19 (2), pp. 1-15. https://doi.org/10.3390/ijms19020484
Can Curcumin Counteract Cognitive Decline? Clinical Trial Evidence and Rationale for Combining ω-3 Fatty Acids with Curcumin
Kuszewski, Julia Christina, Wong, Rachel Heloise Xiwen and Howe, Peter Ranald Charles. 2018. "Can Curcumin Counteract Cognitive Decline? Clinical Trial Evidence and Rationale for Combining ω-3 Fatty Acids with Curcumin." Advances in Nutrition. 9 (2), pp. 105-113. https://doi.org/10.1093/advances/nmx013
Comparison of two low-fat diets, differing in protein and carbohydrate, on psychological wellbeing in adults with obesity and type 2 diabetes: a randomised clinical trial
Watson, Nerylee Ann, Dyer, Kathryn Ann, Buckley, Jonathan David, Brinkworth, Grant David, Coates, Alison Mary, Parfitt, Gaynor, Howe, Peter Ranald Charles, Noakes, Manny and Murphy, Karen Joy. 2018. "Comparison of two low-fat diets, differing in protein and carbohydrate, on psychological wellbeing in adults with obesity and type 2 diabetes: a randomised clinical trial." Nutrition Journal. 17, pp. 1-12. https://doi.org/10.1186/s12937-018-0367-5
Reductions in food cravings are similar with low-fat weight loss diets differing in protein and carbohydrate in overweight and obese adults with type 2 diabetes: A randomized clinical trial
Watson, Nerylee A., Dyer, Kathryn A., Buckley, Jonathan D., Brinkworth, Grant D., Coates, Alison M., Parfitt, Gaynor, Howe, Peter R. C., Noakes, Manny and Murphy, Karen J.. 2018. "Reductions in food cravings are similar with low-fat weight loss diets differing in protein and carbohydrate in overweight and obese adults with type 2 diabetes: A randomized clinical trial." Nutrition Research. 57, pp. 56-66. https://doi.org/10.1016/j.nutres.2018.05.005
Postmenopausal health interventions: Time to move on from the Women’s Health Initiative?
Zaw, Jay Jay Thaung, Howe, Peter Ranald Charles and Wong, Rachel Heloise Xiwen. 2018. "Postmenopausal health interventions: Time to move on from the Women’s Health Initiative?" Ageing Research Reviews. 48, pp. 79-86. https://doi.org/10.1016/j.arr.2018.10.005
Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats
Hassanshahi, Mohammadhossein, Su, Yu‐Wen, Khabbazi, Samira, Fan, Chia‐Ming, Chen, Ke‐Ming, Wang, Ju‐Fang, Qian, Airong, Howe, Peter R., Yan, De‐Wen, Zhou, Hou‐De and Xian, Cory J.. 2019. "Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats." The Journal of Cellular Physiology. 234 (7), pp. 11276-11286. https://doi.org/10.1002/jcp.27785
Repetitive hypoglycemia reduces activation of glucose-responsive neurons in C1 and C3 medullary brain regions to subsequent hypoglycemia
Kakall, Zohra M., Kavurma, Mary M., Cohen, E. Myfanwy, Howe, Peter R., Nedoboy, Polina E. and Pilowsky, Paul M.. 2019. "Repetitive hypoglycemia reduces activation of glucose-responsive neurons in C1 and C3 medullary brain regions to subsequent hypoglycemia." American Journal of Physiology: Endocrinology and Metabolism. 317 (2), pp. E388-E398. https://doi.org/10.1152/ajpendo.00051.2019
Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity
Kuszewski, Julia C., Wong, Rachel H. X. and Howe, Peter R. C.. 2020. "Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity." Rheumatology Advances in Practice. 4 (2), pp. 1-9. https://doi.org/10.1093/rap/rkaa036
Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women
Zaw, Jay Jay Thaung, Howe, Peter R. C. and Wong, Rachel H. X.. 2020. "Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women." Nutrients. 12 (3), pp. 1-14. https://doi.org/10.3390/nu12030828
An Exploratory Analysis of Changes in Mental Wellbeing Following Curcumin and Fish Oil Supplementation in Middle-Aged and Older Adults
Kuszewski, Julia C., Howe, Peter R. C. and Wong, Rachel H. X.. 2020. "An Exploratory Analysis of Changes in Mental Wellbeing Following Curcumin and Fish Oil Supplementation in Middle-Aged and Older Adults." Nutrients. 12 (10), pp. 1-13. https://doi.org/10.3390/nu12102902
Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with Overweight or Obesity
Kuszewski, Julia C., Howe, Peter R. C. and Wong, Rachel H. X.. 2020. "Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with Overweight or Obesity." The Journal of Nutrition. 150 (12), pp. 3190-3199. https://doi.org/10.1093/jn/nxaa299
Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study
Zaw, Jay Jay Thaung, Howe, Peter R. C. and Wong, Rachel H. X.. 2021. "Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study." Clinical Nutrition. 40 (3), pp. 820-829. https://doi.org/10.1016/j.clnu.2020.08.025
Cerebrovascular Function in Hormonal Migraine: An Exploratory Study
Dzator, Jemima S. A., Howe, Peter R. C., Griffiths, Lyn R., Coupland, Kirsten G. and Wong, Rachel H. X.. 2021. "Cerebrovascular Function in Hormonal Migraine: An Exploratory Study." Frontiers in Neurology. 12, pp. 1-12. https://doi.org/10.3389/fneur.2021.694980
Correction: Howe et al. Effects of Long Chain Omega-3 Polyunsaturated Fatty Acids on Brain Function in Mildly Hypertensive Older Adults
Howe, Peter R. C., Evans, Hamish M., Kuszewski, Julia C. and Wong, Rachel H. X.. 2019. "Correction: Howe et al. Effects of Long Chain Omega-3 Polyunsaturated Fatty Acids on Brain Function in Mildly Hypertensive Older Adults." Nutrients. 11 (5), pp. -1. https://doi.org/10.3390/nu11051043
Effects of Long Chain Omega-3 Polyunsaturated Fatty Acids on Brain Function in Mildly Hypertensive Older Adults
Howe, Peter R. C., Evans, Hamish M., Kuszewski, Julia C. and Wong, Rachel H. X.. 2018. "Effects of Long Chain Omega-3 Polyunsaturated Fatty Acids on Brain Function in Mildly Hypertensive Older Adults." Nutrients. 10 (10), pp. 1-14. https://doi.org/10.3390/nu10101413
Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial
Wong, Rachel H. X., Zaw, Jay Jay Thaung, Xian, Cory J. and Howe, Peter R. C.. 2020. "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial." Journal of Bone and Mineral Research. 35 (11), pp. 2121-2131. https://doi.org/10.1002/jbmr.4115
Resveratrol Counteracts Insulin Resistance—Potential Role of the Circulation
Wong, Rachel H. X. and Howe, Peter R. C.. 2018. "Resveratrol Counteracts Insulin Resistance—Potential Role of the Circulation." Nutrients. 10 (9), pp. 1-10. https://doi.org/10.3390/nu10091160
Cognitive Deficits in Type-1 Diabetes: Aspects of Glucose, Cerebrovascular and Amyloid Involvement
Pickering, Justin, Wong, Rachel, Al-Salami, Hani, Lam, Virginie and Takechi, Ryu. 2021. "Cognitive Deficits in Type-1 Diabetes: Aspects of Glucose, Cerebrovascular and Amyloid Involvement." Pharmaceutical Research. 38, pp. 1477-1484. https://doi.org/10.1007/s11095-021-03100-1
Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids
Brook, Emily, Mamo, John, Wong, Rachel, Al-Salami, Hani, Falasca, Marco, Lam, Virginie and Takechi, Ryusuke. 2019. "Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids." Pharmacological Research. 141, pp. 291-297. https://doi.org/10.1016/j.phrs.2019.01.009
A Randomised, Double-Blind, Placebo-Controlled Crossover Trial of Resveratrol Supplementation for Prophylaxis of Hormonal Migraine
Dzator, Jemima S. A., Howe, Peter R. C., Coupland, Kirsten G. and Wong, Rachel H. X.. 2022. "A Randomised, Double-Blind, Placebo-Controlled Crossover Trial of Resveratrol Supplementation for Prophylaxis of Hormonal Migraine." Nutrients. 14 (9). https://doi.org/10.3390/nu14091763
Benefits of exercise training on cerebrovascular and cognitive function in ageing
Bliss, Edward S., Wong, Rachel H. X., Howe, Peter R. C. and Mills, Dean E.. 2021. "Benefits of exercise training on cerebrovascular and cognitive function in ageing." Journal of Cerebral Blood Flow and Metabolism. 41 (3), pp. 447-470. https://doi.org/10.1177/0271678X20957807
Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial
Sinn, Natalie, Milte, Catherine M., Street, Steven J., Buckley, Jonathan D., Coates, Alison M., Petkov, John and Howe, Peter R. C.. 2012. "Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial." The British Journal of Nutrition: an international journal of nutritional science. 107 (11), pp. 1682-1693. https://doi.org/10.1017/S0007114511004788
Metabolic health benefits of long-chain omega-3 polyunsaturated fatty acids
Howe, Peter and Buckley, Jon. 2014. "Metabolic health benefits of long-chain omega-3 polyunsaturated fatty acids." Military Medicine: international journal of AMSUS. 179 (11), pp. 138-143. https://doi.org/10.7205/MILMED-D-14-00154
Cerebrovascular and cognitive benefits of high-oleic peanut consumption in healthy overweight middle-aged adults
Barbour, Jayne A., Howe, Peter R. C., Buckley, Jonathan D., Bryan, Janet and Coates, Alison M.. 2017. "Cerebrovascular and cognitive benefits of high-oleic peanut consumption in healthy overweight middle-aged adults." Nutritional Neuroscience. 20 (10), pp. 555-562. https://doi.org/10.1080/1028415X.2016.1204744
An update from the editorial board of nutrients
Buckley, Jonathan and Howe, Peter. 2015. "An update from the editorial board of nutrients." Nutrients. 7 (7), pp. 5540-5541. https://doi.org/10.3390/nu7075236
Resveratrol supplementation reduces pain experience by postmenopausal women
Wong, Rachel H. X., Evans, Hamish M. and Howe, Peter R. C.. 2017. "Resveratrol supplementation reduces pain experience by postmenopausal women." Menopause. 24 (8), pp. 916-922. https://doi.org/10.1097/GME.0000000000000861
There is no association between the omega-3 index and depressive symptoms in patients with heart disease who are low fish consumers
Cai, Shaoxin, Coates, Alison M., Buckley, Jonathan D., Berry, Narelle M., Burres, Lisa, Beltrame, John, Howe, Peter R. C. and Schrader, Geoffrey. 2017. "There is no association between the omega-3 index and depressive symptoms in patients with heart disease who are low fish consumers." Heart Lung and Circulation. 26 (3), pp. 276-284. https://doi.org/10.1016/j.hlc.2016.07.003
Impaired cerebrovascular responsiveness and cognitive performance in adults with type 2 diabetes
Nealon, Rhenan Scott, Howe, Peter Ranald Charles, Jansen, Lyanne, Garg, Manohar and Wong, Rachel Heloise Xiwen. 2017. "Impaired cerebrovascular responsiveness and cognitive performance in adults with type 2 diabetes." Journal of Diabetes and Its Complications. 31 (2), pp. 462-467. https://doi.org/10.1016/j.jdiacomp.2016.06.025
Impact of cocoa flavanols on cardiovascular health: additional consideration of dose and food matrix [Letter to the Editor]
Davison, Kade and Howe, Peter R. C.. 2017. "Impact of cocoa flavanols on cardiovascular health: additional consideration of dose and food matrix [Letter to the Editor]." Phytotherapy Research. 31 (1), pp. 165-166. https://doi.org/10.1002/ptr.5729
Effects of resveratrol supplementation on methotrexate chemotherapy‐induced bone loss
Lee, Alice M. C., Shandala, Tetyana, Soo, Pei Pei, Su, Yu-Wen, King, Tristan J., Chen, Ke-Ming, Howe, Peter R. and Xian, Cory J.. 2017. "Effects of resveratrol supplementation on methotrexate chemotherapy‐induced bone loss." Nutrients. 9 (3). https://doi.org/10.3390/nu9030255
Effects of resveratrol on cognitive performance, mood and cerebrovascular function in post-menopausal women; a 14-week randomised placebo-controlled intervention trial
Evans, Hamish M., Howe, Peter R. C. and Wong, Rachel H. X.. 2017. "Effects of resveratrol on cognitive performance, mood and cerebrovascular function in post-menopausal women; a 14-week randomised placebo-controlled intervention trial." Nutrients. 9 (1). https://doi.org/10.3390/nu9010027
Abdominal adiposity and obstructive airway disease: Testing insulin resistance and sleep disordered breathing mechanisms
Haren, Matthew T., Misan, Gary, Paterson, Tracey Jayne, Ruffin, Richard E., Grant, Janet F., Buckley, Jonathan D., Howe, Peter R. C., Newbury, Jonathan, Taylor, Anne W. and McDermott, Robyn A.. 2012. "Abdominal adiposity and obstructive airway disease: Testing insulin resistance and sleep disordered breathing mechanisms." BMC Pulmonary Medicine. 12. https://doi.org/10.1186/1471-2466-12-31
Knee extensor strength differences in obese and healthy-weight 10-to 13-year-olds
Tsiros, Margarita D., Coates, Alison M., Howe, Peter R.C., Grimshaw, Paul N., Walkley, Jeff, Shield, Anthony, Mallows, Richard, Hills, Andrew P., Kagawa, Masaharu, Shultz, Sarah and Buckley, Jonathan D.. 2013. "Knee extensor strength differences in obese and healthy-weight 10-to 13-year-olds." European Journal of Applied Physiology. 113 (6), pp. 1415-1422. https://doi.org/10.1007/s00421-012-2561-z
Potential effects of phytoestrogen genistein in modulating acute methotrexate chemotherapy-induced osteoclastogenesis and bone damage in rats
King, Tristan J., Shandala, Tetyana, Lee, Alice M., Foster, Bruce K., Chen, Ke Ming, Howe, Peter R. and Xian, Cory J.. 2015. "Potential effects of phytoestrogen genistein in modulating acute methotrexate chemotherapy-induced osteoclastogenesis and bone damage in rats." International Journal of Molecular Sciences. 16 (8), pp. 18293-18311. https://doi.org/10.3390/ijms160818293
Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults
Wong, Rachel H. X., Berry, Narelle M., Coates, Alison M., Buckley, Jonathan D., Bryan, Janet, Kunz, Iris and Howe, Peter R. C.. 2013. "Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults." Journal of Hypertension. 31 (9), pp. 1819-1827. https://doi.org/10.1097/HJH.0b013e328362b9d6
Polyunsaturated fatty acids, cognition and literacy in children with ADHD with and without learning difficulties
Milte, Catherine M., Sinn, Natalie, Buckley, Jonathan D., Coates, Alison M., Young, Ross M. and Howe, Peter R. C.. 2011. "Polyunsaturated fatty acids, cognition and literacy in children with ADHD with and without learning difficulties." Journal of Child Health Care. 15 (4), pp. 299-311. https://doi.org/10.1177/1367493511403953
Acute effects of an Avena Sativa herb extract on responses to the stroop color-word test
Berry, Narelle M., Robinson, Matthew J., Bryan, Janet, Buckley, Jonathan D., Murphy, Karen J. and Howe, Peter R. C.. 2011. "Acute effects of an Avena Sativa herb extract on responses to the stroop color-word test." Journal of Alternative and Complementary Medicine. 17 (7), pp. 635-637. https://doi.org/10.1089/acm.2010.0450
Dairy consumption and working memory performance in overweight and obese adults
Crichton, Georgina E., Murphy, Karen J., Howe, Peter R. C., Buckley, Jonathan D. and Bryan, Janet. 2012. "Dairy consumption and working memory performance in overweight and obese adults." Appetite. 59 (1), pp. 34-40. https://doi.org/10.1016/j.appet.2012.03.019
Long-term dietary intervention trials: critical issues and challenges
Crichton, Georgina E., Howe, Peter R. C., Buckley, Jonathan D., Coates, Alison M., Murphy, Karen J. and Bryan, Janet. 2012. "Long-term dietary intervention trials: critical issues and challenges." Trials. 13. https://doi.org/10.1186/1745-6215-13-111
Transcranial doppler ultrasound to assess cerebrovascular reactivity: reliability, reproducibility and effect of posture
McDonnell, Michelle N., Berry, Narelle M., Cutting, Mark A., Keage, Hannah A., Buckley, Jonathan D. and Howe, Peter R. C.. 2013. "Transcranial doppler ultrasound to assess cerebrovascular reactivity: reliability, reproducibility and effect of posture." PEERJ. 1, pp. 1-11. https://doi.org/10.7717/peerj.65
Feasibility of ω-3 fatty acid supplementation as an adjunct therapy for people with chronic obstructive pulmonary disease: study protocol for a randomized controlled trial
Fulton, Ashley S., Hill, Alison M., Williams, Marie T., Howe, Peter R. C., Frith, Peter A., Wood, Lisa G., Garg, Manohar L. and Coates, Alison M.. 2013. "Feasibility of ω-3 fatty acid supplementation as an adjunct therapy for people with chronic obstructive pulmonary disease: study protocol for a randomized controlled trial." Trials. 14 (107). https://doi.org/10.1186/1745-6215-14-107
Chronic consumption of a wild green oat extract (Neuravena) improves brachial flow-mediated dilatation and cerebrovascular responsiveness in older adults
Wong, Rachel H. X., Howe, Peter R. C., Coates, Alison M., Buckley, Jonathan D. and Berry, Narelle M.. 2013. "Chronic consumption of a wild green oat extract (Neuravena) improves brachial flow-mediated dilatation and cerebrovascular responsiveness in older adults." Journal of Hypertension. 31 (1), pp. 192-200. https://doi.org/10.1097/HJH.0b013e32835b04d4
Effect of vibration on muscle perfusion: a systematic review
Fuller, Joel T., Thomson, Rebecca L., Howe, Peter R. C. and Buckley, Jonathan D.. 2013. "Effect of vibration on muscle perfusion: a systematic review." Clinical Physiology and Functional Imaging. 33 (1), pp. 1-10. https://doi.org/10.1111/j.1475-097X.2012.01161.x
Musculoskeletal pain in obese compared with healthy-weight children
Tsiros, Margarita D., Buckley, Jonathan D., Howe, Peter R. C., Walkley, Jeff, Hills, Andrew P. and Coates, Alison M.. 2014. "Musculoskeletal pain in obese compared with healthy-weight children." The Clinical Journal of Pain. 30 (7), pp. 583-588. https://doi.org/10.1097/AJP.0000000000000017
Nut consumption for vascular health and cognitive function
Barbour, Jayne A., Howe, Peter R. C., Buckley, Jonathan D., Bryan, Janet and Coates, Alison M.. 2014. "Nut consumption for vascular health and cognitive function." Nutrition Research Reviews. 27 (1), pp. 131-158. https://doi.org/10.1017/S0954422414000079
Impaired physical function associated with childhood obesity: How should we intervene?
Tsiros, Margarita D., Buckley, Jonathan D., Olds, Timothy, Howe, Peter R. C., Hills, Andrew P., Walkley, Jeff, Wood, Rachel, Kagawa, Masaharu, Shield, Anthony, Taylor, Lara, Shultz, Sarah P., Grimshaw, Paul N., Grigg, Kaine and Coates, Alison M.. 2016. "Impaired physical function associated with childhood obesity: How should we intervene?" Childhood Obesity. 12 (2), pp. 126-134. https://doi.org/10.1089/chi.2015.0123
Maximal rate of increase in heart rate during the rest-exercise transition tracks reductions in exercise performance when training load is increased
Nelson, Maximillian J., Thomson, Rebecca L., Rogers, Daniel K., Howe, Peter R. C. and Buckley, Jonathan D.. 2014. "Maximal rate of increase in heart rate during the rest-exercise transition tracks reductions in exercise performance when training load is increased." Journal of Science and Medicine in Sport. 17 (1), pp. 129-133. https://doi.org/10.1016/j.jsams.2013.02.016
Lower energy intake following consumption of Hi-oleic and regular peanuts compared with iso-energetic consumption of potato crisps
Barbour, Jayne A., Howe, Peter R. C., Buckley, Jonathan D., Wright, Graeme C., Bryan, Janet and Coates, Alison M.. 2014. "Lower energy intake following consumption of Hi-oleic and regular peanuts compared with iso-energetic consumption of potato crisps." Appetite. 82, pp. 124-130. https://doi.org/10.1016/j.appet.2014.07.015
Increased erythrocyte eicosapentaenoic acid and docosahexaenoic acid are associated with improved attention and behavior in children with adhd in a randomized controlled three-way crossover trial
Milte, Catherine M., Parletta, Natalie, Buckley, Jonathan D., Coates, Alison M., Young, Ross M. and Howe, Peter R. C.. 2015. "Increased erythrocyte eicosapentaenoic acid and docosahexaenoic acid are associated with improved attention and behavior in children with adhd in a randomized controlled three-way crossover trial." Journal of Attention Disorders. 19 (11), pp. 954-964. https://doi.org/10.1177/1087054713510562
Potential implications of dose and diet for the effects of eocoa flavanols on cardiometabolic function
Davison, Kade and Howe, Peter R C. 2015. "Potential implications of dose and diet for the effects of eocoa flavanols on cardiometabolic function." Journal of Agricultural and Food Chemistry. 63 (45), pp. 9942-9947. https://doi.org/10.1021/acs.jafc.5b01492
Vibration therapy is no more effective than the standard practice of massage and stretching for promoting recovery from muscle damage after eccentric exercise
Fuller, Joel T., Thomson, Rebecca L., Howe, Peter R. C. and Buckley, Jonathan D.. 2015. "Vibration therapy is no more effective than the standard practice of massage and stretching for promoting recovery from muscle damage after eccentric exercise." Clinical Journal of Sport Medicine. 25 (4), pp. 332-337. https://doi.org/10.1097/JSM.0000000000000149
Paucity of evidence for a relationship between long-chain omega-3 fatty acid intake and chronic obstructive pulmonary disease: a systematic review
Fulton, Ashley S., Hill, Alison M., Williams, Marie T., Howe, Peter R. C. and Coates, Alison M.. 2015. "Paucity of evidence for a relationship between long-chain omega-3 fatty acid intake and chronic obstructive pulmonary disease: a systematic review." Nutrition Reviews. 73 (9), pp. 612-623. https://doi.org/10.1093/nutrit/nuv017
Combination chemotherapy with cyclophosphamide, epirubicin and 5-fluorouracil causes trabecular bone loss, bone marrow cell depletion and marrow adiposity in female rats
Fan, Chiaming, Georgiou, Kristen R., McKinnon, Ross A., Keefe, Dorothy M. K., Howe, Peter R. C. and Xian, Cory J.. 2016. "Combination chemotherapy with cyclophosphamide, epirubicin and 5-fluorouracil causes trabecular bone loss, bone marrow cell depletion and marrow adiposity in female rats." Journal of Bone and Mineral Metabolism. 34 (3), pp. 277-290. https://doi.org/10.1007/s00774-015-0679-x
Improvement of major depression is associated with increased erythrocyte DHA
Meyer, Barbara J., Grenyer, Brin F. S., Crowe, Trevor, Owen, Alice J., Grigonis-Deane, Elizabeth M. and Howe, Peter R. C.. 2013. "Improvement of major depression is associated with increased erythrocyte DHA." Lipids. 48 (9), pp. 863-868. https://doi.org/10.1007/s11745-013-3801-7
A randomised trial comparing low-fat diets differing in carbohydrate and protein ratio, combined with regular moderate intensity exercise, on glycaemic control, cardiometabolic risk factors, food cravings, cognitive function and psychological wellbeing in adults with type 2 diabetes: study protocol
Watson, Nerylee Ann, Dyer, Kathryn Ann, Buckley, Jonathan David, Brinkworth, Grant David, Coates, Alison Mary, Parfitt, Gaynor, Howe, Peter Ranald Charles, Noakes, Manny, Dye, Louise, Chadwick, Helen and Murphy, Karen Joy. 2015. "A randomised trial comparing low-fat diets differing in carbohydrate and protein ratio, combined with regular moderate intensity exercise, on glycaemic control, cardiometabolic risk factors, food cravings, cognitive function and psychological wellbeing in adults with type 2 diabetes: study protocol." Contemporary Clinical Trials. 45, pp. 217-225. https://doi.org/10.1016/j.cct.2015.11.001
Obesity: the new childhood disability?
Tsiros, M. D., Coates, A. M., Howe, P. R. C., Grimshaw, P. N. and Buckley, J. D.. 2011. "Obesity: the new childhood disability?" Obesity Reviews. 12 (1), pp. 26-36. https://doi.org/10.1111/j.1467-789X.2009.00706.x
Proximal correlates of metabolic phenotypes during 'at-risk' and 'case' stages of the metabolic disease continuum
Haren, M. T., Misan, G., Grant, J. F., Buckley, J. D., Howe, P. R. C., Taylor, A. W., Newbury, J. and McDermott, R. A.. 2012. "Proximal correlates of metabolic phenotypes during 'at-risk' and 'case' stages of the metabolic disease continuum." Nutrition and Diabetes. 2, pp. 1-11. https://doi.org/10.1038/nutd.2011.20
Erythrocyte polyunsaturated fatty acid status, memory, cognition and mood in older adults with mild cognitive impairment and healthy controls
Milte, Catherine M., Sinn, Natalie, Street, Steven J., Buckley, Jonathan D., Coates, Alison M. and Howe, Peter R. C.. 2011. "Erythrocyte polyunsaturated fatty acid status, memory, cognition and mood in older adults with mild cognitive impairment and healthy controls." Prostaglandins, Leukotrienes and Essential Fatty Acids. 84 (5-6), pp. 153-161. https://doi.org/10.1016/j.plefa.2011.02.002
Dairy consumption and cardiometabolic health: outcomes of a 12-month crossover trial
Crichton, Georgina E., Howe, Peter R. C., Buckley, Jonathan D., Coates, Alison M. and Murphy, Karen J.. 2012. "Dairy consumption and cardiometabolic health: outcomes of a 12-month crossover trial." Nutrition and Metabolism. 9 (19). https://doi.org/10.1186/1743-7075-9-19
Day-to-day physical functioning and disability in obese 10- to 13-year-olds
Tsiros, M. D., Buckley, J. D., Howe, P. R. C., Olds, T., Walkley, J., Taylor, L., Mallows, R., Hills, A. P., Kagawa, M. and Coates, A. M.. 2013. "Day-to-day physical functioning and disability in obese 10- to 13-year-olds." Pediatric Obesity. 8 (1), pp. 31-41. https://doi.org/10.1111/j.2047-6310.2012.00083.x
Fish oil in comparison to folinic acid for protection against adverse effects of methotrexate chemotherapy on bone
Raghu Nadhanan, Rethi, Fan, Chia Ming, Su, Yu Wen, Howe, Peter R. C. and Xian, Cory J.. 2014. "Fish oil in comparison to folinic acid for protection against adverse effects of methotrexate chemotherapy on bone." Journal of Orthopaedic Research. 32 (4), pp. 587-596. https://doi.org/10.1002/jor.22565
Interaction of erythrocyte eicosapentaenoic acid and physical activity predicts reduced risk of mild cognitive impairment
Street, Steven John, Parletta, Natalie, Milte, Catherine, Sullivan, Karen, Hills, Andrew P., Buckley, Jonathan and Howe, Peter. 2015. "Interaction of erythrocyte eicosapentaenoic acid and physical activity predicts reduced risk of mild cognitive impairment." Aging and Mental Health. 19 (10), pp. 885-891. https://doi.org/10.1080/13607863.2014.971705
Adiposity is related to decrements in cardiorespiratory fitness in obese and normal-weight children
Tsiros, M. D., Coates, A. M., Howe, P. R. C., Walkley, J., Hills, A. P., Wood, R. E. and Buckley, J. D.. 2016. "Adiposity is related to decrements in cardiorespiratory fitness in obese and normal-weight children." Pediatric Obesity. 11 (2), pp. 144-150. https://doi.org/10.1111/ijpo.12037
Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study
O'Callaghan, Nathan, Parletta, Natalie, Milte, Catherine M., Benassi-Evans, Bianca, Fenech, Michael and Howe, Peter R. C.. 2014. "Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study." Nutrition. 30 (4), pp. 489-491. https://doi.org/10.1016/j.nut.2013.09.013
Effects of low-fat diets differing in protein and carbohydrate content on cardiometabolic risk factors during weight loss and weight maintenance in obese adults with type 2 diabetes
Watson, Nerylee, Dyer, Kathryn, Buckley, Jonathan, Brinkworth, Grant, Coates, Alison, Parfitt, Gaynor, Howe, Peter, Noakes, Manny and Murphy, Karen. 2016. "Effects of low-fat diets differing in protein and carbohydrate content on cardiometabolic risk factors during weight loss and weight maintenance in obese adults with type 2 diabetes." Nutrients. 8 (5). https://doi.org/10.3390/nu8050289
Effects of resveratrol supplementation on bone growth in young rats and microarchitecture and remodeling in ageing rats
Lee, Alice M. C., Shandala, Tetyana, Nguyen, Long, Muhlhausler, Beverly S., Chen, Ke Ming, Howe, Peter R. and Xian, Cory J.. 2014. "Effects of resveratrol supplementation on bone growth in young rats and microarchitecture and remodeling in ageing rats." Nutrients. 6 (12), pp. 5871-5887. https://doi.org/10.3390/nu6125871
Eicosapentaenoic and docosahexaenoic acids, cognition, and behavior in children with attention-deficit/hyperactivity disorder: A randomized controlled trial
Milte, Catherine M., Parletta, Natalie, Buckley, Jonathan D., Coates, Alison M., Young, Ross M. and Howe, Peter R. C.. 2012. "Eicosapentaenoic and docosahexaenoic acids, cognition, and behavior in children with attention-deficit/hyperactivity disorder: A randomized controlled trial." Nutrition. 28 (6), pp. 670-677. https://doi.org/10.1016/j.nut.2011.12.009
Food groups and fatty acids associated with self-reported depression: An analysis from the Australian National Nutrition and Health Surveys
Meyer, Barbara J., Kolanu, Nithin, Griffiths, David A., Grounds, Ben, Howe, Peter R. C. and Kreis, Irene A.. 2013. "Food groups and fatty acids associated with self-reported depression: An analysis from the Australian National Nutrition and Health Surveys." Nutrition. 29 (7-8), pp. 1042-1047. https://doi.org/10.1016/j.nut.2013.02.006
Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure
Wong, R. H. X., Howe, P. R. C., Buckley, J. D., Coates, A. M., Kunz, I. and Berry, N. M.. 2011. "Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure." Nutrition Metabolism and Cardiovascular Diseases. 21 (11), pp. 851-856. https://doi.org/10.1016/j.numecd.2010.03.003
Chronic effects of a wild green oat extract supplementation on cognitive performance in older adults: a randomised, double-blind, placebo-controlled, crossover trial
Wong, Rachel H. X., Howe, Peter R. C., Bryan, Janet, Coates, Alison M., Buckley, Jonathan D. and Berry, Narelle M.. 2012. "Chronic effects of a wild green oat extract supplementation on cognitive performance in older adults: a randomised, double-blind, placebo-controlled, crossover trial." Nutrients. 4 (5), pp. 331-342. https://doi.org/10.3390/nu4050331
Effects of eating fresh lean pork on cardiometabolic health parameters
Murphy, Karen J., Thomson, Rebecca L., Coates, Alison M., Buckley, Jonathan D. and Howe, Peter R. C.. 2012. "Effects of eating fresh lean pork on cardiometabolic health parameters." Nutrients. 4 (7), pp. 711-723. https://doi.org/10.3390/nu4070711
Acknowledgment of reviewers
Howe, Peter. 2012. "Acknowledgment of reviewers." Nutrients. 4 (3), pp. 151-153. https://doi.org/10.3390/nu4030151
The Australian paradox
Howe, Peter. 2012. "The Australian paradox." Nutrients. 4 (4), p. 258. https://doi.org/10.3390/nu4040258
Dairy foods and dairy protein consumption is inversely related to markers of adiposity in obese men and women
Murphy, Karen J., Crichton, Georgina E., Dyer, Kathryn A., Coates, Alison M., Pettman, Tahna L., Milte, Catherine, Thorp, Alicia A., Berry, Narelle M., Buckley, Jonathan D., Noakes, Manny and Howe, Peter R. C.. 2013. "Dairy foods and dairy protein consumption is inversely related to markers of adiposity in obese men and women." Nutrients. 5 (11), pp. 4665-4684. https://doi.org/10.3390/nu5114665
Proceedings of the 2013 meeting of the Australasian Section of the American Oil Chemists Society (AAOCS)
Murphy, Karen and Howe, Peter. 2013. "Proceedings of the 2013 meeting of the Australasian Section of the American Oil Chemists Society (AAOCS)." Nutrients. 5 (12), pp. 5065-5096. https://doi.org/10.3390/nu5125065
A comparison of regular consumption of fresh lean pork, beef and chicken on body composition: A randomized cross-over trial
Murphy, Karen J., Parker, Barbara, Dyer, Kathryn A., Davis, Courtney R., Coates, Alison M., Buckley, Jonathan D. and Howe, Peter R. C.. 2014. "A comparison of regular consumption of fresh lean pork, beef and chicken on body composition: A randomized cross-over trial." Nutrients. 6 (2), pp. 682-696. https://doi.org/10.3390/nu6020682
Increases in plasma lutein through supplementation are correlated with increases in physical activity and reductions in sedentary time in older adults
Thomson, Rebecca L., Coates, Alison M., Howe, Peter R. C., Bryan, Janet, Matsumoto, Megumi and Buckley, Jonathan D.. 2014. "Increases in plasma lutein through supplementation are correlated with increases in physical activity and reductions in sedentary time in older adults." Nutrients. 6 (3), pp. 974-984. https://doi.org/10.3390/nu6030974
Relationship between erythrocyte omega-3 content and obesity is gender dependent
Howe, Peter R. C., Buckley, Jonathan D., Murphy, Karen J., Pettman, Tahna, Milte, Catherine and Coates, Alison M.. 2014. "Relationship between erythrocyte omega-3 content and obesity is gender dependent." Nutrients. 6 (5), pp. 1850-1860. https://doi.org/10.3390/nu6051850
Acute effects of a dietary non-starch polysaccharide supplement on cognitive performance in healthy middle-aged adults
Best, Talitha, Howe, Peter, Bryan, Janet, Buckley, Jonathan and Scholey, Andrew. 2015. "Acute effects of a dietary non-starch polysaccharide supplement on cognitive performance in healthy middle-aged adults." Nutritional Neuroscience. 18 (2), pp. 76-86. https://doi.org/10.1179/1476830513Y.0000000101
Effect of 12 weeks high oleic peanut consumption on cardio-metabolic risk factors and body composition
Barbour, Jayne A., Howe, Peter R. C., Buckley, Jonathan D., Bryan, Janet and Coates, Alison M.. 2015. "Effect of 12 weeks high oleic peanut consumption on cardio-metabolic risk factors and body composition." Nutrients. 7 (9), pp. 7381-7398. https://doi.org/10.3390/nu7095343
Improved heart rate recovery despite reduced exercise performance following heavy training: A within-subject analysis
Thomson, Rebecca L., Bellenger, Clint R., Howe, Peter R. C., Karavirta, Laura and Buckley, Jonathan D.. 2016. "Improved heart rate recovery despite reduced exercise performance following heavy training: A within-subject analysis." Journal of Science and Medicine in Sport. 19 (3), pp. 255-259. https://doi.org/10.1016/j.jsams.2015.02.010
Effect of acute exercise-induced fatigue on maximal rate of heart rate increase during submaximal cycling
Thomson, Rebecca L., Rogers, Daniel K., Howe, Peter R. C. and Buckley, Jonathan D.. 2016. "Effect of acute exercise-induced fatigue on maximal rate of heart rate increase during submaximal cycling." Research in Sports Medicine. 24 (1), pp. 1-15. https://doi.org/10.1080/15438627.2015.1076414
Monitoring athletic training status using the maximal rate of heart rate increase
Bellenger, Clint R., Thomson, Rebecca L., Howe, Peter R. C., Karavirta, Laura and Buckley, Jonathan D.. 2016. "Monitoring athletic training status using the maximal rate of heart rate increase." Journal of Science and Medicine in Sport. 19 (7), pp. 590-595. https://doi.org/10.1016/j.jsams.2015.07.006
Report on the Fifth International Conference on Natural Products for Health and Beauty (NATPRO 5) held in Thailand, 6–8th May, 2014
Voravuthikunchai, Supayang and Howe, Peter. 2014. "Report on the Fifth International Conference on Natural Products for Health and Beauty (NATPRO 5) held in Thailand, 6–8th May, 2014." Nutrients. 6 (10), pp. 4115-4164. https://doi.org/10.3390/nu6104115
Assessing premorbid cognitive ability in adults with Type 2 Diabetes Mellitus: a review with implications for future intervention studies
Wong, Rachel Heloise Xiwen, Scholey, Andrew and Howe, Peter Ranald Charles. 2014. "Assessing premorbid cognitive ability in adults with Type 2 Diabetes Mellitus: a review with implications for future intervention studies." Current Diabetes Reports. 14 (11). https://doi.org/10.1007/s11892-014-0547-4
Antihypertensive potential of combined extracts of olive leaf, green coffee bean and beetroot: a randomized, double-blind, placebo-controlled crossover trial
Wong, Rachel H. X., Garg, Manohar L., Wood, Lisa G. and Howe, Peter R. C.. 2014. "Antihypertensive potential of combined extracts of olive leaf, green coffee bean and beetroot: a randomized, double-blind, placebo-controlled crossover trial." Nutrients. 6 (11), pp. 4881-4894. https://doi.org/10.3390/nu6114881
Clinical evaluation of effects of chronic resveratrol supplementation on cerebrovascular function, cognition, mood, physical function and general well-being in postmenopausal women—rationale and study design
Evans, Hamish Michael, Howe, Peter Ranald Charles and Wong, Rachel Heloise Xiwen. 2016. "Clinical evaluation of effects of chronic resveratrol supplementation on cerebrovascular function, cognition, mood, physical function and general well-being in postmenopausal women—rationale and study design." Nutrients. 8 (3). https://doi.org/10.3390/nu8030150
Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus
Wong, R. H. X., Nealon, R. S., Scholey, A. and Howe, P. R. C.. 2016. "Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus." Nutrition Metabolism and Cardiovascular Diseases. 26 (5), pp. 393-399. https://doi.org/10.1016/j.numecd.2016.03.003
Acute resveratrol consumption improves neurovascular coupling capacity in adults with type 2 diabetes mellitus
Wong, Rachel H. X., Raederstorff, Daniel and Howe, Peter R. C.. 2016. "Acute resveratrol consumption improves neurovascular coupling capacity in adults with type 2 diabetes mellitus." Nutrients. 8 (7). https://doi.org/10.3390/nu8070425
Poor cerebrovascular function is an early marker of cognitive decline in healthy postmenopausal women
Wong, Rachel H. X., Evans, Hamish M. and Howe, Peter R. C.. 2016. "Poor cerebrovascular function is an early marker of cognitive decline in healthy postmenopausal women." Alzheimer's & Dementia: Translational Research & Clinical Interventions. 2 (3), pp. 162-168. https://doi.org/10.1016/j.trci.2016.07.003
Supplementation with fish oil and genistein, individually or in combination, protects bone against the adverse effects of methotrexate chemotherapy in rats
Nadhanan, Rethi Raghu, Skinner, Jayne, Chung, Rosa, Su, Yu-Wen, Howe, Peter R. and Xian, Cory J.. 2013. "Supplementation with fish oil and genistein, individually or in combination, protects bone against the adverse effects of methotrexate chemotherapy in rats." PLoS One. 8 (8). https://doi.org/10.1371/journal.pone.0071592