Evidence for circulatory benefits of Resveratrol in humans
Article
Article Title | Evidence for circulatory benefits of Resveratrol in humans |
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ERA Journal ID | 11271 |
Article Category | Article |
Authors | Wong, Rachel H. X. (Author), Coates, Alison M. (Author), Buckley, Jonathan D. (Author) and Howe, Peter R. C. (Author) |
Journal Title | Annals of the New York Academy of Sciences |
Journal Citation | 1290 (1), pp. 52-58 |
Number of Pages | 7 |
Year | 2013 |
Place of Publication | United States |
ISSN | 0077-8923 |
1749-6632 | |
Digital Object Identifier (DOI) | https://doi.org/10.1111/nyas.12155 |
Web Address (URL) | http://onlinelibrary.wiley.com/doi/10.1111/nyas.12155/abstract |
Abstract | Impairments of endothelial function, which can be assessed noninvasively by flow-mediated dilation (FMD) of the brachial artery, contribute to the development of cardiovascular disease. Associations between FMD and cognition suggest a vascular component in the loss of cognitive function. Certain vasoactive nutrients that have been shown to improve FMD may also have the potential to enhance cerebral perfusion and cognition. Preclinical studies show that trans-resveratrol can enhance nitric oxide bioavailability, thereby increasing endothelium-dependent vasodilation. We have now shown that acute administration of resveratrol elicits dose-dependent increases of FMD with greater potency than other vasoactive nutrients and that this benefit is sustained following regular consumption. We describe the potential implications of this vasodilator benefit of resveratrol and its role in enhancing cerebrovascular and cognitive functions. |
Keywords | Endothelial function; Flow-mediated dilation; Human; Resveratrol; trans-resveratrol; Vasodilator responsiveness; Cardiovascular Diseases and Cardiovascular Surgery; Clinical and Experimental Pharmacology |
ANZSRC Field of Research 2020 | 320199. Cardiovascular medicine and haematology not elsewhere classified |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | University of South Australia |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q40zy/evidence-for-circulatory-benefits-of-resveratrol-in-humans
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