Cognitive Deficits in Type-1 Diabetes: Aspects of Glucose, Cerebrovascular and Amyloid Involvement

Article

Pickering, Justin, Wong, Rachel, Al-Salami, Hani, Lam, Virginie and Takechi, Ryu. 2021. "Cognitive Deficits in Type-1 Diabetes: Aspects of Glucose, Cerebrovascular and Amyloid Involvement." Pharmaceutical Research. 38, pp. 1477-1484. https://doi.org/10.1007/s11095-021-03100-1
Article Title

Cognitive Deficits in Type-1 Diabetes: Aspects of Glucose, Cerebrovascular and Amyloid Involvement

ERA Journal ID14833
Article CategoryArticle
AuthorsPickering, Justin (Author), Wong, Rachel (Author), Al-Salami, Hani (Author), Lam, Virginie (Author) and Takechi, Ryu (Author)
Journal TitlePharmaceutical Research
Journal Citation38, pp. 1477-1484
Number of Pages8
Year2021
Place of PublicationUnited States
ISSN0724-8741
1573-904X
Digital Object Identifier (DOI)https://doi.org/10.1007/s11095-021-03100-1
Web Address (URL)https://link.springer.com/article/10.1007/s11095-021-03100-1
Abstract

The evidence shows that individuals with type-1 diabetes mellitus (T1DM) are at greater risk of accelerated cognitive impairment and dementia. Although, to date the mechanisms are largely unknown. An emerging body of literature indicates that dysfunction of cerebral neurovascular network and plasma dyshomeostasis of soluble amyloid-β in association with impaired lipid metabolism are central to the onset and progression of cognitive deficits and dementia. However, the latter has not been extensively considered in T1DM. Therefore, in this review, we summarised the literature concerning altered lipid metabolism and cerebrovascular function in T1DM as an implication for potential pathways leading to cognitive decline and dementia.

Keywordsamyloid-beta, cerebrovascular dysfunction, hyperglycemia, type 1 diabetes
ANZSRC Field of Research 2020320999. Neurosciences not elsewhere classified
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Byline AffiliationsCurtin University
Institute for Resilient Regions
Institution of OriginUniversity of Southern Queensland
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