Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults
Article
Article Title | Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults |
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ERA Journal ID | 16401 |
Article Category | Article |
Authors | Wong, Rachel H. X. (Author), Berry, Narelle M. (Author), Coates, Alison M. (Author), Buckley, Jonathan D. (Author), Bryan, Janet (Author), Kunz, Iris (Author) and Howe, Peter R. C. (Author) |
Journal Title | Journal of Hypertension |
Journal Citation | 31 (9), pp. 1819-1827 |
Number of Pages | 9 |
Year | 2013 |
Publisher | Lippincott Williams & Wilkins |
Place of Publication | United Kingdom |
ISSN | 0263-6352 |
1473-5598 | |
Digital Object Identifier (DOI) | https://doi.org/10.1097/HJH.0b013e328362b9d6 |
Web Address (URL) | http://journals.lww.com/jhypertension/pages/articleviewer.aspx?year=2013&issue=09000&article=00011&type=abstract |
Abstract | Background: We have previously demonstrated acute dose-dependent increases of flow-mediated dilatation (FMD) in the brachial artery after resveratrol consumption in mildly hypertensive, overweight/obese adults. Resveratrol supplementation has also been shown to increase cerebral blood flow acutely, without affecting cognition. Objectives: To evaluate the effects of chronic resveratrol supplementation on both FMD and cognitive performance. Method: Twenty-eight obese but otherwise healthy adults (BMI: 33.3±0.6kg/m 2) were randomized to take a single 75 mg capsule of trans-resveratrol (Resvida) or placebo daily for 6 weeks each in a double-blind crossover supplementation trial. Blood pressure, arterial compliance, FMD, and performance on the Stroop Color-Word Test were assessed at the end of each 6-week intervention period while fasted and at least 18 h after taking the last daily capsule. An additional capsule of the same supplement was then taken. FMD assessment was repeated 1 h later. Results: Chronic resveratrol supplementation for 6 weeks was well tolerated and resulted in a 23% increase in FMD compared with placebo (P = 0.021, paired t-test). The extent of increase correlated negatively with baseline FMD (r= -0.47, P=0.01). A single dose of resveratrol (75 mg) following chronic resveratrol supplementation resulted in a 35% greater acute FMD response than the equivalent placebo supplementation. These FMD improvements remained significant after adjusting for baseline FMD. Blood pressure, arterial compliance, and all components of the Stroop Color-Word Test were unaffected by chronic resveratrol supplementation. Conclusion: Daily resveratrol consumption was well tolerated and has the potential to maintain healthy circulatory function in obese adults. |
Keywords | Bioactive nutrients; Cognition; Flow-mediated dilatation; Obesity; Resveratrol; Vascular function; General; Cardiovascular Diseases and Cardiovascular Surgery |
ANZSRC Field of Research 2020 | 320199. Cardiovascular medicine and haematology not elsewhere classified |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Institution of Origin | University of Southern Queensland |
Byline Affiliations | University of South Australia |
DSM Nutritional Products, Switzerland | |
University of Newcastle |
https://research.usq.edu.au/item/q410y/chronic-resveratrol-consumption-improves-brachial-flow-mediated-dilatation-in-healthy-obese-adults
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