Clinical evaluation of effects of chronic resveratrol supplementation on cerebrovascular function, cognition, mood, physical function and general well-being in postmenopausal women—rationale and study design
Article
Article Title | Clinical evaluation of effects of chronic resveratrol supplementation on cerebrovascular function, cognition, mood, physical function and general well-being in postmenopausal women—rationale and study design |
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ERA Journal ID | 211152 |
Article Category | Article |
Authors | Evans, Hamish Michael (Author), Howe, Peter Ranald Charles (Author) and Wong, Rachel Heloise Xiwen (Author) |
Journal Title | Nutrients |
Journal Citation | 8 (3) |
Number of Pages | 14 |
Year | 2016 |
Publisher | MDPI AG |
Place of Publication | Switzerland |
ISSN | 2072-6643 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/nu8030150 |
Web Address (URL) | http://www.mdpi.com/2072-6643/8/7/425 |
Abstract | Background: This methodological paper presents both a scientific rationale and a methodological approach for investigating the effects of resveratrol supplementation on mood and cognitive performance in postmenopausal women. Postmenopausal women have an increased risk of cognitive decline and dementia, which may be at least partly due to loss of beneficial effects of estrogen on the cerebrovasculature. We hypothesise that resveratrol, a phytoestrogen, may counteract this risk by enhancing cerebrovascular function and improving regional blood flow in response to cognitive demands. A clinical trial was designed to test this hypothesis. Method: Healthy postmenopausal women were recruited to participate in a randomised, double-blind, placebo-controlled (parallel comparison) dietary intervention trial to evaluate the effects of resveratrol supplementation (75 mg twice daily) on cognition, cerebrovascular responsiveness to cognitive tasks and overall well-being. They performed the following tests at baseline and after 14 weeks of supplementation: Rey Auditory Verbal Learning Test, Cambridge Semantic Memory Battery, the Double Span and the Trail Making Task. Cerebrovascular function was assessed simultaneously by monitoring blood flow velocity in the middle cerebral arteries using transcranial Doppler ultrasound. Conclusion: This trial provides a model approach to demonstrate that, by optimising circulatory function in the brain, resveratrol and other vasoactive nutrients may enhance mood and cognition and ameliorate the risk of developing dementia in postmenopausal women and other at-risk populations. |
Keywords | Cerebrovascular function; Cognition; Healthy ageing; Mood; Physical function; Postmenopausal; Resveratrol; Transcranial Doppler ultrasound; Vasoactive nutrients; Obstetrics and Gynecology; Clinical and Experimental Biochemistry; Drug Literature Index; Neurology and Neurosurgery |
ANZSRC Field of Research 2020 | 321099. Nutrition and dietetics not elsewhere classified |
Byline Affiliations | University of Newcastle |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q40xw/clinical-evaluation-of-effects-of-chronic-resveratrol-supplementation-on-cerebrovascular-function-cognition-mood-physical-function-and-general-well-being-in-postmenopausal-women-rationale-and-study
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