Erythrocyte polyunsaturated fatty acid status, memory, cognition and mood in older adults with mild cognitive impairment and healthy controls
Article
Article Title | Erythrocyte polyunsaturated fatty acid status, memory, cognition and mood in older adults with mild cognitive impairment and healthy controls |
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ERA Journal ID | 2279 |
Article Category | Article |
Authors | Milte, Catherine M. (Author), Sinn, Natalie (Author), Street, Steven J. (Author), Buckley, Jonathan D. (Author), Coates, Alison M. (Author) and Howe, Peter R. C. (Author) |
Journal Title | Prostaglandins, Leukotrienes and Essential Fatty Acids |
Journal Citation | 84 (5-6), pp. 153-161 |
Number of Pages | 9 |
Year | 2011 |
Place of Publication | United Kingdom |
ISSN | 0952-3278 |
1532-2823 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.plefa.2011.02.002 |
Web Address (URL) | http://www.sciencedirect.com/science/article/pii/S0952327811000196 |
Abstract | Polyunsaturated fatty acid (PUFA) levels are altered in adults with cognitive decline and also depression. Depression facilitates progression from mild cognitive impairment (MCI) to dementia. We investigated associations between omega-3 (n-3) and omega-6 (n-6) PUFAs and cognition, memory and depression in 50 adults ≥65 years with MCI and 29 controls. Memory, depressive symptoms and erythrocyte PUFAs (% total fatty acids) were assessed. Eicosapentaenoic acid (EPA) was lower in MCI vs controls (.94% vs 1.26%, p<01); n-6 PUFAs were higher: dihomo-gamma-linolenic acid (1.51% vs 1.32%, p<01), arachidonic acid (11.54% vs 10.70%, p<01), n-6 docosapentaenoic acid (DPA:.46% vs.34%, p<01), and total n-6 PUFA (24.14% vs 23.37%, p<05). Higher n-6 DPA predicted poorer mental health. Lower n-3 DPA was associated with higher self-reported bodily pain. Adults with MCI had higher depression scores (3.05±39 vs 1.33±24, p<01). Depressive symptoms associated with elevated n-6 PUFA may contribute to cognitive decline in this population. |
Keywords | Dementia; Depression; Mild cognitive impairment; Omega-3 fatty acids; Omega-6 fatty acids; Lipids, Glycolipids, and Polysaccharides; Memory and Learning |
ANZSRC Field of Research 2020 | 320504. Medical biochemistry - lipids |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | University of South Australia |
Queensland University of Technology | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q4111/erythrocyte-polyunsaturated-fatty-acid-status-memory-cognition-and-mood-in-older-adults-with-mild-cognitive-impairment-and-healthy-controls
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