Interaction of erythrocyte eicosapentaenoic acid and physical activity predicts reduced risk of mild cognitive impairment
Article
Article Title | Interaction of erythrocyte eicosapentaenoic acid and physical activity predicts reduced risk of mild cognitive impairment |
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ERA Journal ID | 39992 |
Article Category | Article |
Authors | Street, Steven John (Author), Parletta, Natalie (Author), Milte, Catherine (Author), Sullivan, Karen (Author), Hills, Andrew P. (Author), Buckley, Jonathan (Author) and Howe, Peter (Author) |
Journal Title | Aging and Mental Health |
Journal Citation | 19 (10), pp. 885-891 |
Number of Pages | 7 |
Year | 2015 |
Place of Publication | United Kingdom |
ISSN | 1360-7863 |
1364-6915 | |
Digital Object Identifier (DOI) | https://doi.org/10.1080/13607863.2014.971705 |
Web Address (URL) | http://www.tandfonline.com/doi/full/10.1080/13607863.2014.971705 |
Abstract | Objectives: To evaluate relationships between self-reported physical activity, proportions of long-chain omega-3 polyunsaturated fatty acids (LCn3) in erythrocyte content (percentage of total fatty acids) and risk of mild cognitive impairment (MCI) in older adults.Method: A cross-sectional study was conducted. Community-dwelling male and female (n = 84) participants over the age of 65 years with and without MCI were tested for erythrocyte proportions of the LCn3s eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Physical activity was measured using a validated questionnaire.Results: The interaction between erythrocyte EPA, but not DHA, and increased physical activity was associated with increased odds of a non-MCI classification.Conclusion: An interaction between physical activity and erythrocyte EPA content (percentage of fatty acids) significantly predicted MCI status in older adults. Randomised control trials are needed to examine the potential for supplementation with EPA in combination with increased physical activity to mitigate the risk of MCI in ageing adults. |
Keywords | ageing; DHA; EPA; mild cognitive impairment; physical activity; Aged; Aged, 80 and over; Aging; Cross-Sectional Studies; Dietary Supplements; Docosahexaenoic Acids; Eicosapentaenoic Acid; Erythrocytes; Fatty Acids, Omega-3; Female; Mild Cognitive Impairment; Motor Activity; Surveys and Questionnaires |
ANZSRC Field of Research 2020 | 420301. Aged health care |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Queensland University of Technology |
University of South Australia | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q40y7/interaction-of-erythrocyte-eicosapentaenoic-acid-and-physical-activity-predicts-reduced-risk-of-mild-cognitive-impairment
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