Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial
Article
Article Title | Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial |
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ERA Journal ID | 13733 |
Article Category | Article |
Authors | Kuszewski, Julia C. (Author), Wong, Rachel H. X. (Author), Wood, Lisa G. (Author) and Howe, Peter R. C. (Author) |
Journal Title | Nutrition Metabolism and Cardiovascular Diseases |
Journal Citation | 30 (4), pp. 625-633 |
Number of Pages | 9 |
Year | 2020 |
Place of Publication | United Kingdom |
ISSN | 0939-4753 |
1590-3729 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.numecd.2019.12.010 |
Web Address (URL) | https://www.nmcd-journal.com/article/S0939-4753(19)30459-4/fulltext |
Abstract | Background and aims: Chronic conditions such as obesity, which contribute to endothelial dysfunction in older adults, can cause impairments in cerebrovascular perfusion, which is associated with accelerated cognitive decline. Supplementing the diet with bioactive nutrients that can enhance endothelial function, such as fish oil or curcumin, may help to counteract cerebrovascular dysfunction. Methods and results: A 16-week double-blind, randomized placebo-controlled trial was undertaken in 152 older sedentary overweight/obese adults (50–80 years, body mass index: 25–40 kg/m2) to investigate effects of fish oil (2000 mg docosahexaenoic acid + 400 mg eicosapentaenoic acid/day), curcumin (160 mg/day) or a combination of both on cerebrovascular function (measured by Transcranial Doppler ultrasound), systemic vascular function (blood pressure, heart rate and arterial compliance) and cardiometabolic (fasting glucose and blood lipids) and inflammatory (C-reactive protein) biomarkers. The primary outcome, cerebrovascular responsiveness to hypercapnia, was not affected by the interventions. However, cerebral artery stiffness was significantly reduced in males following fish oil supplementation (P = 0.007). Furthermore, fish oil reduced heart rate (P = 0.038) and serum triglycerides (P = 0.006) and increased HDL cholesterol (P = 0.002). Curcumin did not significantly affect these outcomes either alone or in combination with fish oil. Conclusion: Regular supplementation with fish oil but not curcumin improved biomarkers of cardiovascular and cerebrovascular function. The combined supplementation did not result in additional benefits. Further studies are warranted to identify an efficacious curcumin dose and to characterize (in terms of sex, BMI, cardiovascular and metabolic risk factors) populations whose cerebrovascular and cognitive functions might benefit from either intervention. |
Keywords | Cerebrovascular function, Fish oil, Curcumin, Endothelial function, Inflammation |
ANZSRC Field of Research 2020 | 320199. Cardiovascular medicine and haematology not elsewhere classified |
320999. Neurosciences not elsewhere classified | |
321099. Nutrition and dietetics not elsewhere classified | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Institution of Origin | University of Southern Queensland |
Byline Affiliations | University of Newcastle |
Centre for Health Research (Operations) | |
Institute for Resilient Regions |
https://research.usq.edu.au/item/q7q25/effects-of-fish-oil-and-curcumin-supplementation-on-cerebrovascular-function-in-older-adults-a-randomized-controlled-trial
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