Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with Overweight or Obesity
Article
Article Title | Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with Overweight or Obesity |
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ERA Journal ID | 13658 |
Article Category | Article |
Authors | Kuszewski, Julia C. (Author), Howe, Peter R. C. (Author) and Wong, Rachel H. X. (Author) |
Journal Title | The Journal of Nutrition |
Journal Citation | 150 (12), pp. 3190-3199 |
Number of Pages | 10 |
Year | 2020 |
Place of Publication | United States |
ISSN | 0022-3166 |
1541-6100 | |
Digital Object Identifier (DOI) | https://doi.org/10.1093/jn/nxaa299 |
Web Address (URL) | https://academic.oup.com/jn/article/150/12/3190/5936684 |
Abstract | Background: Obesity accelerates age-related cognitive decline, which is partly mediated by vascular dysfunction. Objective: The aim was to test the hypothesis that supplementation with fish oil and curcumin can enhance cognitive performance by improving cerebral circulatory function in overweight or obese middle-aged to older adults. Methods: In a 16-wk double-blind, placebo-controlled intervention trial, adults [50–80 y; BMI (kg/m2): 25–40] were randomly assigned to either fish oil (2000 mg/d DHA + 400 mg/d EPA), curcumin (160 mg/d), or a combination. Effects on cerebrovascular function (primary outcome) and cardiovascular risk factors were reported previously. Effects on cognitive performance and cerebrovascular responsiveness (CVR) to cognitive stimuli are reported herein. One-factor ANOVA with post hoc analyses was conducted between groups in the whole cohort and in males and females separately. Two-factor ANOVA was conducted to assess independent effects of fish oil and curcumin and a potential interaction. Correlations between outcomes (those obtained herein and previously reported) were also examined. Results: Compared with placebo, fish oil improved CVR to a processing speed test (4.4% ± 1.9% vs. −2.2% ± 2.1%; P = 0.023) and processing speed in males only (Z-score: 0.6 ± 0.2 vs. 0.1 ± 0.2; P = 0.043). Changes in processing speed correlated inversely with changes in blood pressure (R = −0.243, P = 0.006) and C-reactive protein (R = −0.183, P = 0.046). Curcumin improved CVR in a working memory test (3.6% ± 1.2% vs. −0.2% ± 0.2%, P = 0.026) and, in males only, performance of a verbal memory test compared with placebo (Z-score: 0.2 ± 0.1 vs. −0.5 ± 0.2, P = 0.039). Combining fish oil with curcumin did not produce additional benefits. Conclusions: Improvements in processing speed following fish-oil supplementation in middle-aged to older males might be mediated by improvements in circulatory function. Mechanisms underlying the cognitive benefit seen with curcumin are unknown. As cognitive benefits were found in males only, further evaluation of sex differences in responsiveness to supplementation is warranted. |
Keywords | cognitive function, fish oil, curcumin, cardiovascular risk factors, cerebrovascular function, randomized controlled trial |
ANZSRC Field of Research 2020 | 321099. Nutrition and dietetics not elsewhere classified |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Institution of Origin | University of Southern Queensland |
Byline Affiliations | University of Newcastle |
Institute for Resilient Regions |
https://research.usq.edu.au/item/q7q28/evaluation-of-cognitive-performance-following-fish-oil-and-curcumin-supplementation-in-middle-aged-and-older-adults-with-overweight-or-obesity
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