Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study
Article
Article Title | Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study |
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ERA Journal ID | 13728 |
211152 | |
Article Category | Article |
Authors | O'Callaghan, Nathan (Author), Parletta, Natalie (Author), Milte, Catherine M. (Author), Benassi-Evans, Bianca (Author), Fenech, Michael (Author) and Howe, Peter R. C. (Author) |
Journal Title | Nutrition |
Nutrients | |
Journal Citation | 30 (4), pp. 489-491 |
Number of Pages | 3 |
Year | 2014 |
Publisher | MDPI AG |
Place of Publication | United States |
ISSN | 0899-9007 |
1873-1244 | |
2072-6643 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.nut.2013.09.013 |
Web Address (URL) | http://www.sciencedirect.com/science/article/pii/S0899900713004450 |
Abstract | Objectives: Excessive shortening of the telomeric ends of chromosomes is a marker of accelerated aging. Oxidative stress and nutritional deficiency may influence this process. The aim of this study was to investigate the effect of ω-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on telomeric shortening in elderly individuals with mild cognitive impairment (MCI). Methods: Thirty-three adults ages > 65 y with MCI were randomized to receive a supplement rich in the long-chain ω-3 PUFAs eicosapentaenoic acid (EPA; 1.67 g EPA + 0.16 g docosahexaenoic acid DHA/d; n = 12) or DHA (1.55 g DHA + 0.40 g EPA/d; n = 12), versus ω-6 PUFA linoleic acid (LA; 2.2 g/d; n = 9) for 6 mo. Results: The intervention did not show an increase in telomere length with treatment and there was a trend toward telomere shortening during the intervention period. Linear mixed modeling produced a robust model although statistically underpowered. Telomere shortening was greatest in the LA group (d = 0.21) than in the DHA (d = 0.12) and EPA groups (d = 0.06). Increased erythrocyte DHA levels were associated with reduced telomere shortening (r = -0.67; P = 0.02) in the DHA group. Conclusion: Telomeric shortening may be attenuated by ω-3 PUFA supplementation, requiring further investigation in larger samples. |
Keywords | DHA; Elderly; EPA; Mild cognitive impairment; Telomere length; ω-3 fatty acids |
ANZSRC Field of Research 2020 | 320199. Cardiovascular medicine and haematology not elsewhere classified |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia |
University of South Australia | |
University of Newcastle | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q411v/telomere-shortening-in-elderly-individuals-with-mild-cognitive-impairment-may-be-attenuated-with-3-fatty-acid-supplementation-a-randomized-controlled-pilot-study
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