Metabolic health benefits of long-chain omega-3 polyunsaturated fatty acids
Article
Article Title | Metabolic health benefits of long-chain omega-3 polyunsaturated fatty acids |
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ERA Journal ID | 40335 |
Article Category | Article |
Authors | Howe, Peter (Author) and Buckley, Jon (Author) |
Journal Title | Military Medicine: international journal of AMSUS |
Journal Citation | 179 (11), pp. 138-143 |
Number of Pages | 6 |
Year | 2014 |
Publisher | Oxford University Press |
Place of Publication | United States |
ISSN | 0026-4075 |
1930-613X | |
Digital Object Identifier (DOI) | https://doi.org/10.7205/MILMED-D-14-00154 |
Web Address (URL) | http://militarymedicine.amsus.org/doi/abs/10.7205/MILMED-D-14-00154 |
Abstract | Restricting energy intake and increasing physical activity are advocated for reducing obesity, but many individuals have difficulty complying with these recommendations. Consumption of long-chain omega-3 polyunsaturated fatty acids (n-3 LCPUFA) offers multiple mechanisms to counteract obesity, including appetite suppression; circulatory improvements, which promote nutrient delivery to skeletal muscle and changes in gene expression, which shift metabolism toward increased fat oxidation; increased energy expenditure; and reduced fat deposition. n-3 LCPUFA may also alter gene expression in skeletal muscle to suppress catabolic pathways and upregulate anabolic pathways, resulting in greater lean tissue mass, metabolic rate, and maintenance of physical function. n-3 LCPUFA supplementation has been shown to counteract obesity in rodents, but evidence in humans is limited. Epidemiological associations between n-3 LCPUFA intakes and obesity are inconclusive. Several studies, on the other hand, indicate inverse relationships between biomarkers of n-3 LCPUFA status and obesity, although causality is uncertain. There have been few human intervention trials of omega-3 supplementation for obesity; some have indicated potential benefits, especially when combined with energy-restricted diets or exercise. More trials are needed to confirm these effects and identify mechanisms of action. |
Keywords | Appetite Regulation; Blood Circulation; Energy Metabolism; Fatty Acids, Omega-3; Humans; Lipid Metabolism; Muscle, Skeletal; Obesity |
ANZSRC Field of Research 2020 | 321099. Nutrition and dietetics not elsewhere classified |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | University of South Australia |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q40z3/metabolic-health-benefits-of-long-chain-omega-3-polyunsaturated-fatty-acids
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