Associations between Cerebrovascular Function and the Expression of Genes Related to Endothelial Function in Hormonal Migraine
Article
Dzator, Jemima S. A., Smith, Robert A., Coupland, Kirsten G., Howe, Peter R. C. and Griffiths, Lyn R.. 2024. "Associations between Cerebrovascular Function and the Expression of Genes Related to Endothelial Function in Hormonal Migraine." International Journal of Molecular Sciences. 25 (3). https://doi.org/10.3390/ijms25031694
| Article Title | Associations between Cerebrovascular Function and the Expression of Genes Related to Endothelial Function in Hormonal Migraine |
|---|---|
| ERA Journal ID | 41930 |
| Article Category | Article |
| Authors | Dzator, Jemima S. A., Smith, Robert A., Coupland, Kirsten G., Howe, Peter R. C. and Griffiths, Lyn R. |
| Journal Title | International Journal of Molecular Sciences |
| Journal Citation | 25 (3) |
| Article Number | 1694 |
| Number of Pages | 12 |
| Year | 2024 |
| Publisher | MDPI AG |
| Place of Publication | Switzerland |
| ISSN | 1422-0067 |
| Digital Object Identifier (DOI) | https://doi.org/10.3390/ijms25031694 |
| Web Address (URL) | https://www.mdpi.com/1422-0067/25/3/1694 |
| Abstract | There is evidence to suggest that hormonal migraine is associated with altered cerebrovascular function. We aimed to investigate whether the expression of genes related to endothelial function in venous blood (1) might influence cerebrovascular function, (2) differs between hormonal migraineur and non-migraineur women, and (3) changes following resveratrol supplementation. This study utilised data obtained from 87 women (59 hormonal migraineurs and 28 controls) where RNA from venous blood was used to quantify gene expression and transcranial Doppler ultrasound was used to evaluate cerebrovascular function. Spearman’s correlation analyses were performed between gene expression, cerebrovascular function, and migraine-related disability. We compared the expression of genes associated with endothelial function between migraineurs and non-migraineurs, and between resveratrol and placebo. The expression of several genes related to endothelial function was associated with alterations in cerebrovascular function. Notably, the expression of CALCA was associated with increased neurovascular coupling capacity (p = 0.013), and both CALCA (p = 0.035) and VEGF (p = 0.014) expression were associated with increased cerebral blood flow velocity in the overall study population. Additionally, VCAM1 expression correlated with decreased pulsatility index (a measure of cerebral arterial stiffness) (p = 0.009) and headache impact test-6 scores (p = 0.007) in the migraineurs. No significant differences in gene expression were observed between migraineurs and controls, or between placebo and resveratrol treatments in migraineurs. Thus, altering the expression of genes related to endothelial function may improve cerebrovascular function and decrease migraine-related disability. |
| Keywords | cerebrovascular; endothelial function; gene expression; hormonal migraine; migraine; resveratrol |
| Contains Sensitive Content | Does not contain sensitive content |
| ANZSRC Field of Research 2020 | 310505. Gene expression (incl. microarray and other genome-wide approaches) |
| Byline Affiliations | University of Newcastle |
| Griffith University | |
| Queensland University of Technology | |
| Hunter Medical Research Institute, Australia | |
| Centre for Health Research | |
| University of Adelaide |
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