Chronic consumption of a wild green oat extract (Neuravena) improves brachial flow-mediated dilatation and cerebrovascular responsiveness in older adults
Article
Article Title | Chronic consumption of a wild green oat extract (Neuravena) improves brachial flow-mediated dilatation and cerebrovascular responsiveness in older adults |
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ERA Journal ID | 16401 |
Article Category | Article |
Authors | Wong, Rachel H. X. (Author), Howe, Peter R. C. (Author), Coates, Alison M. (Author), Buckley, Jonathan D. (Author) and Berry, Narelle M. (Author) |
Journal Title | Journal of Hypertension |
Journal Citation | 31 (1), pp. 192-200 |
Number of Pages | 9 |
Year | 2013 |
Publisher | Lippincott Williams & Wilkins |
Place of Publication | United Kingdom |
ISSN | 0263-6352 |
1473-5598 | |
Digital Object Identifier (DOI) | https://doi.org/10.1097/HJH.0b013e32835b04d4 |
Web Address (URL) | http://journals.lww.com/jhypertension/pages/articleviewer.aspx?year=2013&issue=01000&article=00028&type=abstract |
Abstract | Background: Heart health benefits have been attributed to regular consumption of oats. Preclinical evidence suggests that a wild green oat extract (WGOE) may improve vasodilator function, but this is yet to be evaluated in humans. Objective: To determine whether regular daily consumption of WGOE can influence vasodilator function in systemic and cerebral arteries. Methods: Thirty-seven healthy older adults (>60 years) completed a 24-week randomized, double-blind, placebo-controlled two-way crossover dietary intervention with 1500 mg/day of encapsulated WGOE or placebo. All assessments were conducted at the end of each 12-week intervention arm, after participants had fasted for at least 4 h and at least 18 h after they had taken their last dose of supplement. Flow-mediated dilatation (FMD) of the brachial artery and hypercapnia-induced increases of blood flow in the middle cerebral artery were used to measure systemic and cerebral vasodilator responsiveness (CVR), respectively. Results: Compared with placebo, WGOE supplementation increased CVR and FMD to a similar extent (42 and 41%, respectively, P < 0.01 for both). The improvements in CVR and FMD were not correlated. Resting blood pressure did not alter with supplementation. Dose and treatment duration were well tolerated by participants. Conclusion: WGOE supplementation can improve vasodilator function in systemic and cerebral arteries, suggesting a potential role in the maintenance of cardiovascular health. |
Keywords | Avena sativa; avenanthramides; bioactive nutrients; cerebrovascular responsiveness; flow-mediated dilatation; wild green oats; General; Cardiovascular Diseases and Cardiovascular Surgery; Clinical and Experimental Pharmacology |
ANZSRC Field of Research 2020 | 320199. Cardiovascular medicine and haematology not elsewhere classified |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | University of South Australia |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q40zx/chronic-consumption-of-a-wild-green-oat-extract-neuravena-improves-brachial-flow-mediated-dilatation-and-cerebrovascular-responsiveness-in-older-adults
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