Impaired cerebrovascular responsiveness and cognitive performance in adults with type 2 diabetes
Article
Article Title | Impaired cerebrovascular responsiveness and cognitive performance in adults with type 2 diabetes |
---|---|
ERA Journal ID | 16358 |
Article Category | Article |
Authors | Nealon, Rhenan Scott (Author), Howe, Peter Ranald Charles (Author), Jansen, Lyanne (Author), Garg, Manohar (Author) and Wong, Rachel Heloise Xiwen (Author) |
Journal Title | Journal of Diabetes and Its Complications |
Journal Citation | 31 (2), pp. 462-467 |
Number of Pages | 6 |
Year | 2017 |
Publisher | Elsevier |
Place of Publication | United States |
ISSN | 1056-8727 |
1873-460X | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.jdiacomp.2016.06.025 |
Web Address (URL) | http://www.sciencedirect.com/science/article/pii/S1056872716302549?via%3Dihub |
Abstract | Aim: Cognitive deficits in type 2 diabetes mellitus (T2DM) may be partly attributable to stiffness in cerebral arteries and impaired vasodilator function, limiting the ability to increase blood flow in brain regions to meet cognitive demands. We undertook a comparison of cerebrovascular responsiveness (CVR) and cognitive performance in adults with and without T2DM. Methods: Older adults with (50) and without (Herath, Cherbuin, Eramudugolla, & Anstey, 2016) T2DM underwent transcranial Doppler ultrasound measurements of basal cerebral mean blood flow velocity (MBFV) and pulsatility index (PI), a measure of arterial stiffness, in the middle cerebral arteries (MCA). A battery of tasks assessing domains of working memory, executive function and information processing/motor speed was then administered while MBFV was recorded. CVR to cognitive tasks was calculated as a percentage increase in MBFV from the basal level. Results: There was no difference in basal MBFV between groups. However, PI was 14% higher in the T2DM group (P < 0.05), who performed poorer across all cognitive domains assessed and displayed poorer CVR in three tasks. Cognitive performance was inversely related to the PI/MBFV ratio, an indicator of intracranial stenosis. Discussion: Impaired cerebral perfusion during mental tasks is accompanied by poor cognitive performance and stiffness in the cerebral vessels. |
Keywords | arterial stiffness; cerebral perfusion; cognitive decline; diabetes mellitus; transcranial doppler |
ANZSRC Field of Research 2020 | 320899. Medical physiology not elsewhere classified |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | University of Newcastle |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q40x6/impaired-cerebrovascular-responsiveness-and-cognitive-performance-in-adults-with-type-2-diabetes
1120
total views8
total downloads2
views this month0
downloads this month