The effects of inspiratory muscle training on interleukin-6 concentration during cycling exercise and volitional hyperpnoea

Poster


Mills, Dean, Johnson, Michael, McPhilimey, Martin, Williams, Neil, Gonzalez, Javier, Barnett, Yvonne and Sharpe, Graham. 2012. "The effects of inspiratory muscle training on interleukin-6 concentration during cycling exercise and volitional hyperpnoea." 22nd European Respiratory Society Annual Congress. Vienna, Austria 01 - 05 Sep 2012 Switzerland.
Paper/Presentation Title

The effects of inspiratory muscle training on interleukin-6 concentration during cycling exercise and volitional hyperpnoea

Presentation TypePoster
AuthorsMills, Dean (Author), Johnson, Michael (Author), McPhilimey, Martin (Author), Williams, Neil (Author), Gonzalez, Javier (Author), Barnett, Yvonne (Author) and Sharpe, Graham (Author)
Journal or Proceedings TitleEuropean Respiratory Journal
Journal Citation40 (56 (Supplement)), p. 2322
Number of Pages1
Year2012
Place of PublicationSwitzerland
ISSN0903-1936
1399-3003
Web Address (URL) of Paperhttp://erj.ersjournals.com/content/erj/40/Suppl_56/P2322.full.pdf
Conference/Event22nd European Respiratory Society Annual Congress
Event Details
22nd European Respiratory Society Annual Congress
Event Date
01 to end of 05 Sep 2012
Event Location
Vienna, Austria
Abstract

The plasma concentration of interleukin-6 (IL-6) increases during cycling exercise (EX) (Starkie et al. J. Physiol 2001; 533:585-591) and inspiratory resistive breathing (IRB) (Vassilakopoulos et al. Am. J. Physiol 1999; 277:R1013–R1019). Whether inspiratory muscle training (IMT) can attenuate the magnitude of the IL-6 response to EX and volitional hyperpnoea (VH) rather than IRB is unknown. Therefore, we tested the hypothesis that IMT would reduce the IL-6 response to EX and/or VH.

Twelve male participants performed either 6 weeks of pressure-threshold IMT (n=6) or placebo (PLA) training (n=6). Before and after training, participants undertook three 1 hour experimental trials on separate days: (i) passive rest; (ii) EX; and (iii) VH. EX was performed at maximum lactate steady state power. In VH, participants voluntarily mimicked at rest the breathing and respiratory muscle recruitment pattern attained during EX.

IL-6 peaked immediately after EX for both the IMT and PLA groups (6.75 ± 1.6 and 5.64 ± 1.76 pg·mL-1). Following training, this response was reduced (-33%; P=0.027) for the IMT but not the PLA group. Blood lactate concentration ([Lac-]B) during EX was also reduced (-35%; P=0.009) for the IMT group only. IL-6 and [Lac-]B increased (P<0.05) during VH in both groups, but there was no effect of training on these responses. There were no increases in IL-6 or [Lac-]B over time for either group during passive rest.

In conclusion, 6 weeks of IMT reduces IL-6 during EX but not VH. The reduction in IL-6 concentration following IMT may be related to a decreased carbohydrate utilisation as indicated by the post-IMT reduction in [Lac-]B during EX but not VH.

Keywordsimmunology; anti-inflammatory; exercise
ANZSRC Field of Research 2020420702. Exercise physiology
Public Notes

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Byline AffiliationsNottingham Trent University, United Kingdom
South Warwickshire University NHS Trust, United Kingdom
Northumbria University, United Kingdom
Institution of OriginUniversity of Southern Queensland
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