The effects of volitional hyperpnea on biomarkers of respiratory muscle damage in healthy young men

Article

Iqbal, Muneeb, Bliss, Edward, Whiteside, Eliza J., Hoffman, Ben and Mills, Dean. 2024. "The effects of volitional hyperpnea on biomarkers of respiratory muscle damage in healthy young men." Physiological Reports. 13 (6). https://doi.org/10.14814/phy2.70277
Article Title

The effects of volitional hyperpnea on biomarkers of respiratory muscle damage in healthy young men

ERA Journal ID201375
Article CategoryArticle
AuthorsIqbal, Muneeb, Bliss, Edward, Whiteside, Eliza J., Hoffman, Ben and Mills, Dean
Journal TitlePhysiological Reports
Journal Citation13 (6)
Article Numbere72027
Number of Pages12
Year2024
PublisherJohn Wiley & Sons
Place of PublicationUnited Kingdom
ISSN2051-817X
Digital Object Identifier (DOI)https://doi.org/10.14814/phy2.70277
Web Address (URL)https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.70277
Abstract

High-intensity exercise hyperpnea places substantial demands upon the respiratory muscles, but whether this causes respiratory muscle damage is unknown. We investigated respiratory muscle damage following volitional hyperpnea (equivalent to 85% of participants maximum minute ventilation produced during a maximal incremental cycling test) using a skeletal muscle damage biomarker panel. Eight healthy men (33 + 2 years) underwent 10-min trials of volitional hyperpnea and rest (control) two weeks apart. Serum was collected before and at 1, 24, and 48 h after both volitional hyperpnea and control trials. Creatine kinase muscle-type (CKM), fast skeletal troponin I (sTnI) and slow sTnI were measured using enzyme-linked immunosorbent assay. Two-way analysis of variance revealed time × trial interaction effects for slow sTnI (p = 0.018), but not for CKM (p = 0.072) and fast sTnI (p = 0.140). Slow sTnI was significantly higher at +24 h post volitional hyperpnea (p < 0.001) as compared to the same time point of the control trial. These results indicate that high-intensity exercise hyperpnea may induce a small amount of respiratory muscle damage as evidenced by the increases in slow sTnI. Future studies including more time points, different respiratory muscle exercise protocols, and examining the differences between sexes could provide additional insights into the utility of blood biomarkers for identifying respiratory muscle damage.

Keywordsrespiratory muscle damage; biomarkers; volitional hyperpnea; skeletal troponin I
Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020420702. Exercise physiology
Byline AffiliationsSchool of Health and Medical Sciences
Centre for Health Research
Institute for Resilient Regions
Centre for Future Materials
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Thomas, Patrick, Walpole, Carina Maree, Jeffery, Penny, Jovanovic, Lidija, Herington, Adrian, Nelson, Colleen, Whiteside, Eliza, Veedu, Rakesh, Seim, Inge and Chopin, Lisa. 2018. "The long non-coding RNA, GHSROS, mediates prostate cancer growth ." Annual Scientific Meeting of the Endocrine Society of Australia 2016. Gold Coast, Australia 21 - 24 Aug 2016 United Kingdom . John Wiley & Sons. https://doi.org/10.1111/cen.13259
The impact of strength level on adaptations to combined weightlifting, plyometric, and ballistic training
James, L. P., Haff, G. Gregory, Kelly, V. G., Connick, M. J., Hoffman, B. W. and Beckman, E. M.. 2018. "The impact of strength level on adaptations to combined weightlifting, plyometric, and ballistic training ." Scandinavian Journal of Medicine and Science in Sports. 28 (5), pp. 1494-1505. https://doi.org/10.1111/sms.13045
Protection from muscle damage in the absence of changes in muscle mechanical behavior
Hoffman, Ben W., Cresswell, Andrew G., Carroll, Timothy J. and Lichtwark, Glen A.. 2016. "Protection from muscle damage in the absence of changes in muscle mechanical behavior." Medicine and Science in Sports and Exercise. 48 (8), pp. 1495-1505. https://doi.org/10.1249/MSS.0000000000000920
Implementing an online student laboratory data repository in a first year undergraduate health science course
Engstrom, Craig, Bulmer, Michael, Newcombe, Peter and Hoffman, Ben. 2017. "Implementing an online student laboratory data repository in a first year undergraduate health science course." International Journal of Information and Education Technology. 7 (2), pp. 100-105. https://doi.org/10.18178/ijiet.2017.7.2.849
Oxygen supplementation for preventing adverse outcomes following surgery or invasive procedures
Eager, Amanda, Ralph, Nicholas, Duff, Jed, Conway, Aaron and Mills, Dean. 2017. "Oxygen supplementation for preventing adverse outcomes following surgery or invasive procedures." PROSPERO: International Prospective Register of Systematic Reviews. 16 June 2017.
Inspiratory muscle warm-up does not improve cycling time trial performance
Gregson, Ian, Mills, Dean, Gonzalez, Javier, Sharpe, Graham and Johnson, Michael. 2012. "Inspiratory muscle warm-up does not improve cycling time trial performance." 22nd European Respiratory Society Annual Congress. Vienna, Austria 01 - 05 Sep 2012 Switzerland.
Stress, COMT polymorphisms, and depressive symptoms in older Australian women: an exploratory study
Seib, Charrlotte, Whiteside, Eliza, Voisey, Joanne, Lee, Kathryn, Alexander, Kimberly, Humphreys, Janice, Chopin, Lisa and Anderson, Debra. 2016. "Stress, COMT polymorphisms, and depressive symptoms in older Australian women: an exploratory study." Genetic Testing and Molecular Biomarkers. 20 (8), pp. 478-481. https://doi.org/10.1089/gtmb.2015.0028
The effects of pressure-threshold inspiratory load on lactate clearance after maximal exercise
Johnson, Michael, Brown, David, Bayfield, Katie, Gonzalez, Javier, Mills, Dean and Sharpe, Graham. 2011. "The effects of pressure-threshold inspiratory load on lactate clearance after maximal exercise." 21st European Respiratory Society Annual Congress. Amsterdam, Netherlands 24 - 28 Sep 2011 Switzerland.
The effects of inspiratory muscle training on breathing mechanics during fixed load cycling exercise
Mills, Dean, Sharpe, Graham, Johnson, Michael and Barnett, Yvonne. 2011. "The effects of inspiratory muscle training on breathing mechanics during fixed load cycling exercise." 21st European Respiratory Society Annual Congress. Amsterdam, Netherlands 24 - 28 Sep 2011 Switzerland.
The effects of inspiratory muscle training on the interleukin-6 response to intense volitional hyperpnoea
Mills, Dean, Johnson, Michael, McPhilimey, Martin, Williams, Neil, Gonzalez, Javier, Barnett, Yvonne and Sharpe, Graham. 2012. "The effects of inspiratory muscle training on the interleukin-6 response to intense volitional hyperpnoea." 22nd European Respiratory Society Annual Congress. Vienna, Austria 01 - 05 Sep 2012 Switzerland.
The effects of inspiratory muscle training on interleukin-6 concentration during cycling exercise and volitional hyperpnoea
Mills, Dean, Johnson, Michael, McPhilimey, Martin, Williams, Neil, Gonzalez, Javier, Barnett, Yvonne and Sharpe, Graham. 2012. "The effects of inspiratory muscle training on interleukin-6 concentration during cycling exercise and volitional hyperpnoea." 22nd European Respiratory Society Annual Congress. Vienna, Austria 01 - 05 Sep 2012 Switzerland.
Inspiratory loading intensity does not influence lactate clearance during recovery
Johnson, Michael A., Mills, Dean E., Brown, David M., Bayfield, Katie J., Gonzalez, Javier T. and Sharpe, Graham R.. 2012. "Inspiratory loading intensity does not influence lactate clearance during recovery." Medicine and Science in Sports and Exercise. 44 (5), pp. 863-871. https://doi.org/10.1249/MSS.0b013e31824079d0
Influence of oxidative stress, diaphragm fatigue and inspiratory muscle training on the plasma cytokine response to maximum sustainable voluntary ventilation
Mills, Dean E., Johnson, Michael A., McPhilimey, Martin J., Williams, Neil C., Gonzalez, Javier T., Barnett, Yvonne A. and Sharpe, Graham R.. 2014. "Influence of oxidative stress, diaphragm fatigue and inspiratory muscle training on the plasma cytokine response to maximum sustainable voluntary ventilation." Journal of Applied Physiology. 116 (8), pp. 970-979. https://doi.org/10.1152/japplphysiol.01271.2013
Prior upper body exercise reduces cycling work capacity but not critical power
Johnson, Michael A., Mills, Dean E., Brown, Peter I. and Sharpe, Graham R.. 2014. "Prior upper body exercise reduces cycling work capacity but not critical power." Medicine and Science in Sports and Exercise. 46 (4), pp. 802-808. https://doi.org/10.1249/MSS.0000000000000159
The effects of inspiratory muscle training on plasma interleukin-6 concentration during cycling exercise and a volitional mimic of the exercise hyperpnea
Mills, Dean E., Johnson, Michael A., McPhilimey, Martin J., Williams, Neil C., Gonzalez, Javier T., Barnett, Yvonne A. and Sharpe, Graham R.. 2013. "The effects of inspiratory muscle training on plasma interleukin-6 concentration during cycling exercise and a volitional mimic of the exercise hyperpnea." Journal of Applied Physiology. 115 (8), pp. 1163-1172. https://doi.org/10.1152/japplphysiol.00272.2013
Ghrelin and cancer
Chopin, Lisa, Walpole, Carina, Seim, Inge, Cunningham, Peter, Murray, Rachael, Whiteside, Eliza, Josh, Peter and Herington, Adrian. 2011. "Ghrelin and cancer." Molecular and Cellular Endocrinology. 340 (1), pp. 65-69. https://doi.org/10.1016/j.mce.2011.04.013
Ghrelin O-acyltransferase (GOAT) is expressed in prostate cancer tissues and cell lines and expression is differentially regulated in vitro by ghrelin
Seim, Inge, Jeffery, Penny L., de Amorim, Laura, Walpole, Carina M., Fung, Jenny, Whiteside, Eliza J., Lourie, Rohan, Herington, Adrian C. and Chopin, Lisa K.. 2013. "Ghrelin O-acyltransferase (GOAT) is expressed in prostate cancer tissues and cell lines and expression is differentially regulated in vitro by ghrelin." Reproductive Biology and Endocrinology. 11 (1), pp. 70-78. https://doi.org/10.1186/1477-7827-11-70
Response [to the Chiappa et al letter to the editor]
Johnson, Michael A., Mills, Dean E., Brown, Peter I. and Sharpe, Graham R.. 2013. "Response [to the Chiappa et al letter to the editor]." Medicine and Science in Sports and Exercise. 45 (1), pp. 214-215. https://doi.org/10.1249/MSS.0b013e31826aade2
Targeting the Long Non-Coding RNA GHSROS, a Mediator of Prostate Cancer Tumour Growth, with Antisense Oligonucleotides
Thomas, Patrick B, Walpole, Carina M, Jeffrey, Penny L, Jovanovic, Lidija, Herington, Adrian C, Nelson, Colleen C, Whiteside, Eliza, Veedu, Rakesh N, Seim, Inge and Chopin, Lisa K.. 2016. "Targeting the Long Non-Coding RNA GHSROS, a Mediator of Prostate Cancer Tumour Growth, with Antisense Oligonucleotides." 17th Asia‐Pacific Prostate Cancer Conference. Australia 03 - 31 Aug 2016 United Kingdom . John Wiley & Sons.
Inspiratory muscle warm-up does not improve cycling time-trial performance
Johnson, M. A., Gregson, I. R., Mills, D. E., Gonzalez, J. T. and Sharpe, G. R.. 2014. "Inspiratory muscle warm-up does not improve cycling time-trial performance." European Journal of Applied Physiology. 114 (9), pp. 1821-1830. https://doi.org/10.1007/s00421-014-2914-x
The effects of inspiratory muscle training in older adults
Mills, Dean E., Johnson, Michael A., Barnett, Yvonne A., Smith, William H. T. and Sharpe, Graham R.. 2015. "The effects of inspiratory muscle training in older adults." Medicine and Science in Sports and Exercise. 47 (4), pp. 691-697. https://doi.org/10.1249/MSS.0000000000000474
Location of residence and breast cancer stage: a SEER population-based analysis
Brandon, Lindsay, Youl, Pip, Baade, Peter, Whiteside, Eliza and Kimlin, Michael. 2015. "Location of residence and breast cancer stage: a SEER population-based analysis." The Breast Journal. 21 (6), pp. 693-695. https://doi.org/10.1111/tbj.12499
Stress, lifestyle, and quality of life in midlife and older Australian women: results from the stress and the health of women study
Seib, Charrlotte, Whiteside, Eliza, Lee, Kathryn, Humphreys, Janice, Dao Tran, Tiet Hanh, Chopin, Lisa and Anderson, Debra. 2014. "Stress, lifestyle, and quality of life in midlife and older Australian women: results from the stress and the health of women study." Women's Health Issues. 24 (1), pp. e43-e52. https://doi.org/10.1016/j.whi.2013.11.004
A longitudinal study of the impact of chronic psychological stress on health-related quality of life and clinical biomarkers: protocol for the Australian Healthy Aging of Women Study
Seib, Charrlotte, Whiteside, Eliza J., Humphreys, Janice, Lee, Kathryn, Thomas, Patrick, Chopin, Lisa, Crisp, Gabrielle, O'Keeffe, Angela, Kimlin, Michael, Stacey, Andrew and Anderson, Debra. 2014. "A longitudinal study of the impact of chronic psychological stress on health-related quality of life and clinical biomarkers: protocol for the Australian Healthy Aging of Women Study." BMC Public Health. 14 (1), pp. 1-8. https://doi.org/10.1186/1471-2458-14-9
You don't know what you don't know: ethics and participant consent issues for eResearch users
Ostini, Jenny, Gacenga, Francis, Pocock, Celmara and Whiteside, Eliza. 2014. "You don't know what you don't know: ethics and participant consent issues for eResearch users." eResearch Australasia 2014 Conference: Towards Unified Global Research. Melbourne, Australia 27 - 31 Oct 2014 Sydney, Australia.
Multi-species sequence comparison reveals conservation of ghrelin gene-derived splice variants encoding a truncated ghrelin peptide
Seim, Inge, Jeffrey, Penny L., Thomas, Patrick B., Walpole, Carina M., Maugham, Michelle, Fung, Jenny N. T., Yap, Pei-Yi, O'Keeffe, Angela, Lai, John, Whiteside, Eliza J., Herington, Adrian C. and Chopin, Lisa K.. 2016. "Multi-species sequence comparison reveals conservation of ghrelin gene-derived splice variants encoding a truncated ghrelin peptide." Endocrine. 52 (3), pp. 609-617. https://doi.org/10.1007/s12020-015-0848-7
Cloning of a novel insulin-regulated ghrelin transcript in prostate cancer
Seim, Inge, Lubik, Amy A., Lehman, Melanie L., Tomlinson, Nadine, Whiteside, Eliza J., Herington, Adrian C., Nelson, Colleen C. and Chopin, Lisa K.. 2013. "Cloning of a novel insulin-regulated ghrelin transcript in prostate cancer." Journal of Molecular Endocrinology. 50 (2), pp. 179-191. https://doi.org/10.1530/JME-12-0150
Identification of a long non-coding RNA gene, growth hormone secretagogue receptor opposite strand, which stimulates cell migration in non-small cell lung cancer cell lines
Whiteside, Eliza J., Seim, Inge, Pauli, Jana P., O'Keefe, Angela J., Thomas, Patrick B., Carter, Shea L., Walpole, Carina M., Fung, Jenny N. T., Josh, Peter, Herington, Adrian C. and Chopin, Lisa K.. 2013. "Identification of a long non-coding RNA gene, growth hormone secretagogue receptor opposite strand, which stimulates cell migration in non-small cell lung cancer cell lines." International Journal of Oncology. 43 (2), pp. 566-574. https://doi.org/10.3892/ijo.2013.1969
Cortical and spinal excitability during and after lengthening contractions of the human plantar flexor muscles performed with maximal voluntary effort
Hahn, Daniel, Hoffman, Ben W., Carroll, Timothy J. and Cresswell, Andrew G.. 2012. "Cortical and spinal excitability during and after lengthening contractions of the human plantar flexor muscles performed with maximal voluntary effort." PLoS One. 7 (11), pp. 1-9. https://doi.org/10.1371/journal.pone.0049907
A comparison of two Hill-type skeletal muscle models on the construction of medial gastrocnemius length-tension curves in humans in vivo
Hoffman, B. W., Lichtwark, G. A., Carroll, T. J. and Cresswell, A. G.. 2012. "A comparison of two Hill-type skeletal muscle models on the construction of medial gastrocnemius length-tension curves in humans in vivo." Journal of Applied Physiology. 113 (1), pp. 90-96. https://doi.org/10.1152/japplphysiol.00070.2012
Increases in corticospinal responsiveness during a sustained submaximal plantar flexion
Hoffman, B. W., Oya, T., Carroll, T. J. and Cresswell, A. G.. 2009. "Increases in corticospinal responsiveness during a sustained submaximal plantar flexion." Journal of Applied Physiology. 107 (1), pp. 112-120. https://doi.org/10.1152/japplphysiol.91541.2008
Corticospinal-evoked responses in lower limb muscles during voluntary contractions at varying strengths
Oya, T., Hoffman, B. W. and Cresswell, A. G.. 2008. "Corticospinal-evoked responses in lower limb muscles during voluntary contractions at varying strengths." Journal of Applied Physiology. 105 (5), pp. 1527-1532. https://doi.org/10.1152/japplphysiol.90586.2008
Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis?
Pantaleon, M., Whiteside, E. J., Harvey, M.B., Barnard, R.T., Waters, M.J. and Kaye, P.L.. 1997. "Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis?" University of Adelaide. 94 (10), pp. 5125-5130. https://doi.org/10.1073/pnas.94.10.5125