Identification of a long non-coding RNA gene, growth hormone secretagogue receptor opposite strand, which stimulates cell migration in non-small cell lung cancer cell lines
Article
Whiteside, Eliza J., Seim, Inge, Pauli, Jana P., O'Keefe, Angela J., Thomas, Patrick B., Carter, Shea L., Walpole, Carina M., Fung, Jenny N. T., Josh, Peter, Herington, Adrian C. and Chopin, Lisa K.. 2013. "Identification of a long non-coding RNA gene, growth hormone secretagogue receptor opposite strand, which stimulates cell migration in non-small cell lung cancer cell lines." International Journal of Oncology. 43 (2), pp. 566-574. https://doi.org/10.3892/ijo.2013.1969
| Article Title | Identification of a long non-coding RNA gene, growth hormone secretagogue receptor opposite strand, which stimulates cell migration in non-small cell lung cancer cell lines |
|---|---|
| ERA Journal ID | 16264 |
| Article Category | Article |
| Authors | Whiteside, Eliza J. (Author), Seim, Inge (Author), Pauli, Jana P. (Author), O'Keefe, Angela J. (Author), Thomas, Patrick B. (Author), Carter, Shea L. (Author), Walpole, Carina M. (Author), Fung, Jenny N. T. (Author), Josh, Peter (Author), Herington, Adrian C. (Author) and Chopin, Lisa K. (Author) |
| Journal Title | International Journal of Oncology |
| Journal Citation | 43 (2), pp. 566-574 |
| Number of Pages | 9 |
| Year | 2013 |
| Place of Publication | Athens, Greece |
| ISSN | 1019-6439 |
| 1791-2423 | |
| Digital Object Identifier (DOI) | https://doi.org/10.3892/ijo.2013.1969 |
| Web Address (URL) | http://www.spandidos-publications.com/10.3892/ijo.2013.1969 |
| Abstract | The molecular mechanisms involved in non-small cell lung cancer tumourigenesis are largely unknown; however, recent studies have suggested that long non-coding RNAs (lncRNAs) are likely to play a role. In this study, we used public databases to identify an mRNA-like, candidate long non-coding RNA, GHSROS (GHSR opposite strand), transcribed from the antisense strand of the ghrelin receptor gene, growth hormone secretagogue receptor (GHSR). Quantitative real-time RT-PCR revealed higher expression of GHSROS in lung cancer tissue compared to adjacent, non-tumour lung tissue. In common with many long non-coding RNAs, GHSROS is 5′ capped and 3′ polyadenylated (mRNA-like), lacks an extensive open reading frame and harbours a transposable element. Engineered overexpression of GHSROS stimulated cell migration in the A549 and NCI-H1299 non-small cell lung cancer cell lines, but suppressed cell migration in the Beas-2B normal lung-derived bronchoepithelial cell line. This suggests that GHSROS function may be dependent on the oncogenic context. The identification of GHSROS, which is expressed in lung cancer and stimulates cell migration in lung cancer cell lines, contributes to the growing number of non-coding RNAs that play a role in the regulation of tumourigenesis and metastatic cancer progression. |
| Keywords | antisense transcript; cell migration; ghrelin receptor gene; long non-coding RNA; lung cancer; non-small cell lung carcinoma |
| ANZSRC Field of Research 2020 | 321101. Cancer cell biology |
| 321108. Molecular targets | |
| 310506. Gene mapping | |
| Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
| Byline Affiliations | Queensland University of Technology |
| University of Queensland | |
| Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia | |
| Institution of Origin | University of Southern Queensland |
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