Ghrelin O-acyltransferase (GOAT) is expressed in prostate cancer tissues and cell lines and expression is differentially regulated in vitro by ghrelin
Article
Seim, Inge, Jeffery, Penny L., de Amorim, Laura, Walpole, Carina M., Fung, Jenny, Whiteside, Eliza J., Lourie, Rohan, Herington, Adrian C. and Chopin, Lisa K.. 2013. "Ghrelin O-acyltransferase (GOAT) is expressed in prostate cancer tissues and cell lines and expression is differentially regulated in vitro by ghrelin." Reproductive Biology and Endocrinology. 11 (1), pp. 70-78. https://doi.org/10.1186/1477-7827-11-70
| Article Title | Ghrelin O-acyltransferase (GOAT) is expressed in prostate cancer tissues and cell lines and expression is differentially regulated in vitro by ghrelin |
|---|---|
| ERA Journal ID | 40724 |
| Article Category | Article |
| Authors | Seim, Inge (Author), Jeffery, Penny L. (Author), de Amorim, Laura (Author), Walpole, Carina M. (Author), Fung, Jenny (Author), Whiteside, Eliza J. (Author), Lourie, Rohan (Author), Herington, Adrian C. (Author) and Chopin, Lisa K. (Author) |
| Journal Title | Reproductive Biology and Endocrinology |
| Journal Citation | 11 (1), pp. 70-78 |
| Article Number | 70 |
| Number of Pages | 9 |
| Year | 2013 |
| Place of Publication | London, United Kingdom |
| ISSN | 1477-7827 |
| Digital Object Identifier (DOI) | https://doi.org/10.1186/1477-7827-11-70 |
| Web Address (URL) | http://www.rbej.com/content/11/1/70 |
| Abstract | Background: Ghrelin is a 28 amino acid peptide hormone that is expressed in the stomach and a range of peripheral tissues, where it frequently acts as an autocrine/paracrine growth factor. Ghrelin is modified by a unique acylation required for it to activate its cognate receptor, the growth hormone secretagogue receptor (GHSR), which mediates many of the actions of ghrelin. Recently, the enzyme responsible for adding the fatty acid residue (octanoyl/acyl group) to the third amino acid of ghrelin, GOAT (ghrelin O-acyltransferase), was identified. |
| Keywords | acyl-modification; ghrelin; GOAT; prohormone convertase; prostate cancer |
| ANZSRC Field of Research 2020 | 321101. Cancer cell biology |
| 310106. Enzymes | |
| 320501. Medical biochemistry - amino acids and metabolites | |
| Institution of Origin | University of Southern Queensland |
| Byline Affiliations | Queensland University of Technology |
| Ghrelin Research Group, Australia | |
| Australian Prostate Cancer Research Centre, Australia | |
| University of Queensland | |
| University of Queensland |
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