Stress, COMT polymorphisms, and depressive symptoms in older Australian women: an exploratory study
Article
Article Title | Stress, COMT polymorphisms, and depressive symptoms in older Australian women: an exploratory study |
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ERA Journal ID | 2422 |
Article Category | Article |
Authors | Seib, Charrlotte (Author), Whiteside, Eliza (Author), Voisey, Joanne (Author), Lee, Kathryn (Author), Alexander, Kimberly (Author), Humphreys, Janice (Author), Chopin, Lisa (Author) and Anderson, Debra (Author) |
Journal Title | Genetic Testing and Molecular Biomarkers |
Journal Citation | 20 (8), pp. 478-481 |
Number of Pages | 4 |
Year | 2016 |
Place of Publication | United States |
ISSN | 1945-0257 |
1945-0265 | |
Digital Object Identifier (DOI) | https://doi.org/10.1089/gtmb.2015.0028 |
Web Address (URL) | http://online.liebertpub.com/doi/abs/10.1089/gtmb.2015.0028 |
Abstract | Objectives: This exploratory study examined the association between exposure to stressful life events, polymorphisms (rs165774 and rs4680) in the catechol-O-methyltransferase (COMT) gene, and risk of depression in women. Materials and Methods: A cross-sectional design gathered information from 150 Australia women, aged 60–70 years, on sociodemographics, stressful life events, and depressive symptoms. Participants also provided buccal cell swabs for genetic analysis. Results: Among women exposed to stressful life events, the odds of depressive symptoms increased by 18% with each additional exposure (95% confidence interval [95% CI] 1.04–1.33, p = 0.007). Women who carried at least one “A” allele (AA/AG) for both rs165774 and rs4680 single nucleotide polymorphisms were less likely to report depressive symptoms (compared with women with the GG genotype; p = 0.019 and p = 0.037, respectively), although moderation analysis did not support the hypotheses of an interaction with stressful life events (rs165774: odds ratio [OR] = 1.13, 95% CI 0.87–1.46, p = 0.347; rs4680: OR = 1.15, 95% CI 0.91–1.44, p = 0.238). Conclusion: Our research suggests that women with polymorphisms in COMT were less susceptible to depressive symptoms but these polymorphisms do not appear to influence susceptibility to depression in those exposed to life stressors. Further research should consider other genetic variants in catecholamine pathways and their potential impact on women's mental health. |
Keywords | stressful life events (SLEs); polymorphisms; rs165774; rs4680; catechol-O-methyltransferase COMT gene; depression |
ANZSRC Field of Research 2020 | 429999. Other health sciences not elsewhere classified |
310506. Gene mapping | |
Public Notes | File reproduced in accordance with the copyright policy of the publisher/author. |
Byline Affiliations | Queensland University of Technology |
University of Southern Queensland | |
University of California, United States | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q3wqv/stress-comt-polymorphisms-and-depressive-symptoms-in-older-australian-women-an-exploratory-study
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