The advantages of microneedle patches compared to conventional needle-based drug delivery and biopsy devices in medicine

Article

Reinke, Alissa, Whiteside, Eliza J, Windus, Louisa, Desai, Devang, Stehr, Emma and Faraji Rad, Zahra. 2024. "The advantages of microneedle patches compared to conventional needle-based drug delivery and biopsy devices in medicine." Biomedical Engineering Advances. 8. https://doi.org/10.1016/j.bea.2024.100127
Article Title

The advantages of microneedle patches compared to conventional needle-based drug delivery and biopsy devices in medicine

Article CategoryArticle
AuthorsReinke, Alissa, Whiteside, Eliza J, Windus, Louisa, Desai, Devang, Stehr, Emma and Faraji Rad, Zahra
Journal TitleBiomedical Engineering Advances
Journal Citation8
Article Number100127
Number of Pages9
Year2024
PublisherElsevier
Place of PublicationNetherlands
ISSN2667-0992
Digital Object Identifier (DOI)https://doi.org/10.1016/j.bea.2024.100127
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S2667099224000161
Abstract

Microneedle (MN) patches are composed of micron-sized needles organised in arrays and attached to the backing of a patch. The most common type is the transdermal patch, designed to uniformly penetrate the stratum corneum to reach the dermis of the skin. Recent advances in 3D printing technology have allowed the development of reproducible, efficient methods to create microneedles on a large scale, which had previously been a factor in the limited clinical uptake. In comparison to conventional drug delivery methods, MN patches have been shown to significantly reduce pain and scar generation while maintaining effective and reliable delivery of vaccines, immunotherapies, and slow-release drug therapies. The MN design has also been investigated as an alternative to conventional tissue biopsy, with positive results. Synchronous delivery of medications while monitoring biomarkers in dermal interstitial fluid (ISF) is also a promising clinical development with wide-reaching benefits. MNs are diverse in design and material composition, and with developments in fabrication technology, transdermal drug delivery has been applied to many clinical fields, including chronic illnesses such as arthritis or diabetes, cancer, immunotherapies, epidemic disease prevention and ocular treatments. While the majority of MN patch applications are still in the pre-clinical testing phase in animal models, further translation of this technology to the clinic could aid in medication and vaccine compliance, improve treatment access in rural and remote communities, improve targeted therapy applications and provide financial cost savings to the public health sector. This review evaluates the designs and applications of current transdermal MN patches for drug delivery, biomarker monitoring and diagnostic biopsies compared to conventional needle-based methods.

KeywordsMicroneedle; Drug delivery ; Vaccination; Diabetes management ; Biopsy
Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020320602. Medical biotechnology diagnostics (incl. biosensors)
Byline AffiliationsSchool of Health and Medical Sciences
Centre for Health Research
Institute for Resilient Regions
Centre for Future Materials
Institute for Advanced Engineering and Space Sciences
Toowoomba Hospital, Australia
Prince Charles Hospital, Australia
School of Engineering
Permalink -

https://research.usq.edu.au/item/z77q4/the-advantages-of-microneedle-patches-compared-to-conventional-needle-based-drug-delivery-and-biopsy-devices-in-medicine

Log in to edit

Download files

Published Version
1-s2.0-S2667099224000161-main.pdf
License: CC BY 4.0
File access level: Anyone

  • 37
    total views
  • 5
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Export as

Related outputs

The effects of inspiratory muscle training on biomarkers of muscle damage in recovered COVID-19 patients after weaning from mechanical ventilation
Iqbal, Muneeb, Hassan, Kumail, Bliss, Edward, Whiteside, Eliza J, Hoffman, Ben and Mills, Dean E. 2024. "The effects of inspiratory muscle training on biomarkers of muscle damage in recovered COVID-19 patients after weaning from mechanical ventilation." Chronic Respiratory Disease. 21. https://doi.org/10.1177/14799731241289423
A narrative review exploring the attitudes of nursing and complementary medicine students and practitioners toward biosciences curricula
Yeeles, J., Whiteside, E., Haeusler, C., Donovan, J. and Myer, S.. 2024. "A narrative review exploring the attitudes of nursing and complementary medicine students and practitioners toward biosciences curricula." Journal of Further and Higher Education. https://doi.org/10.1080/0309877X.2024.2410972
A Review of the Enablers and Barriers of Medical Student Participation in Research
Mayne, Chance, Bates, Hannah, Desai, Devang and Martin, Priya. 2024. "A Review of the Enablers and Barriers of Medical Student Participation in Research." Medical Science Educator. https://doi.org/10.1007/s40670-024-02156-z
A low-cost, antimicrobial aloe-alginate hydrogel film containing Australian First Nations remedy ‘lemon myrtle oil’ (Backhousia citriodora) – Potential for incorporation into wound dressings
Seneviratne, Dinuki M., Raphael, Brooke, Whiteside, Eliza J., Windus, Louisa C.E., Kauter, Kate, Dearnaley, John D.W., Annamalai, Pratheep K., Ward, Raelene, Song, Pingan and Burey, Paulomi (Polly). 2024. " A low-cost, antimicrobial aloe-alginate hydrogel film containing Australian First Nations remedy ‘lemon myrtle oil’ (Backhousia citriodora) – Potential for incorporation into wound dressings." Heliyon. 10 (18). https://doi.org/10.1016/j.heliyon.2024.e37516
Perspectives on improving wound care for Aboriginal health workers in rural and remote communities in Queensland, Australia
King, Helena, Whiteside, Eliza, Ward, Raelene, Kauter, Kate, Byrne, Martin, Horner, Vicki, Nutter, Helen and Lea, Jackie. 2024. "Perspectives on improving wound care for Aboriginal health workers in rural and remote communities in Queensland, Australia." BMC Health Services Research. 24. https://doi.org/10.1186/s12913-024-11490-2
A curious case: Concurrent collecting duct renal cell carcinoma and upper tract urothelial carcinoma
Rahman, Adib, Matheson, Daniel, Perry-Keene, Joanna and Desai, Devang. 2024. "A curious case: Concurrent collecting duct renal cell carcinoma and upper tract urothelial carcinoma." Urology Case Reports. 54. https://doi.org/10.1016/j.eucr.2024.102698
UrethroNAV: the aetiology and extent of idiopathic urethral stricture in an Australian population
Desai, Devang, Harrison, William, Raveenthiran, Sheliyan, Samaratunga, Hemamali and De Win, Gunter. 2024. "UrethroNAV: the aetiology and extent of idiopathic urethral stricture in an Australian population." Translational Andrology and Urology. 13 (3), pp. 423-432. https://doi.org/10.21037/tau-23-549
Mechanics of dissolving microneedles insertion into the skin: Finite element and experimental analyses
Babapour, Fatemeh, Faraji Rad, Zahra and Ganji, Fariba. 2024. "Mechanics of dissolving microneedles insertion into the skin: Finite element and experimental analyses." Journal of Applied Polymer Science. 141 (38). https://doi.org/10.1002/app.55973
Catheter-associated meatal pressure injuries (CAMPI) in patients with long-term urethral catheters—a cross-sectional study of 200 patients
Munien, Kale, Ravichandran, Kapilan, Flynn, Hannah, Shugg, Nathan, Flynn, David, Chamber, Jonathan and Desai, Devang. 2024. "Catheter-associated meatal pressure injuries (CAMPI) in patients with long-term urethral catheters—a cross-sectional study of 200 patients." Translational Andrology and Urology. 13 (1). https://doi.org/10.21037/tau-23-445
Enhancing diagnostic value in urethral imaging: the case for urologist-performed urethrograms
Harrison, William, Ravichandran, Kapilan, Munien, Kale and Desai, Devang. 2024. "Enhancing diagnostic value in urethral imaging: the case for urologist-performed urethrograms." Trends in Urology and Men's Health. 15 (2), pp. 5-10. https://doi.org/10.1002/tre.957
Robotic surgery education in Australia and New Zealand: primetime for a curriculum
Harrison, William, Munien, Kale and Desai, Devang. 2024. "Robotic surgery education in Australia and New Zealand: primetime for a curriculum." ANZ Journal of Surgery. 94 (1-2), pp. 30-36. https://doi.org/10.1111/ans.18843
Influence of Low-Frequency Vibration and Skin Strain on Insertion Mechanics and Drug Diffusion of PVA/PVP Dissolving Microneedles
Ebrahiminejad, Vahid, Malek-Khatabi, Atefeh and Faraji Rad, Zahra. 2024. "Influence of Low-Frequency Vibration and Skin Strain on Insertion Mechanics and Drug Diffusion of PVA/PVP Dissolving Microneedles." Advanced Materials Technologies. 9 (4). https://doi.org/10.1002/admt.202301272
Botulinum toxin A dissolving microneedles for hyperhidrosis treatment: design, formulation and in vivo evaluation
Malek-Khatabi, Atefeh, Rad-Malekshahi, Mazda, Shafiei, Morvarid, Sharifi, Fatemeh, Motasadizadeh, Hamidreza, Ebrahiminejad, Vahid, Rad-Malekshahi, Mazdak, Akbarijavar, Hamid and Faraji Rad, Zahra. 2023. "Botulinum toxin A dissolving microneedles for hyperhidrosis treatment: design, formulation and in vivo evaluation." Biomaterials Science. 11 (24), pp. 7784-7804. https://doi.org/10.1039/d3bm01301d
Induction of Reactive Bone Stromal Fibroblasts in 3D Models of Prostate Cancer Bone Metastases
Windus, Louisa C. E., Matigian, Nicholas and Avery, Vicky M.. 2023. "Induction of Reactive Bone Stromal Fibroblasts in 3D Models of Prostate Cancer Bone Metastases." Biology. 12 (6). https://doi.org/10.3390/biology12060861
Advancements in minimally invasive bilateral ileal ureter replacement: a promising approach for complex long-segment ureteric strictures
Harrison, William, Munien, Kale and Desai, Devang. 2023. "Advancements in minimally invasive bilateral ileal ureter replacement: a promising approach for complex long-segment ureteric strictures." Translational Andrology and Urology. 12 (8), pp. 1215-1218. https://doi.org/10.21037/tau-23-284
The role of microneedles in the healing of chronic wounds
Ghiyasi, Yasaman, Prewett, Philip D, Davies, Graham J and Faraji Rad, Zahra. 2023. "The role of microneedles in the healing of chronic wounds." International Journal of Pharmaceutics. 641. https://doi.org/10.1016/j.ijpharm.2023.123087
Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery
Malek-Khatabi, A., Razavi, M.S., Abdollahi, A., Rahimzadeghan, M., Moammeri, F., Sheikhi, M., Tavakoli, M., Rad-Malekshahi, M. and Faraji Rad, Z.. 2023. "Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery." Biomaterials Science. 11 (16), pp. 5390-5409. https://doi.org/10.1039/D3BM00795B
Construction and Deconstruction: Materials and substances from 'waste'
Burey, Paulomi, Feldman, Jessica, Seligmann, Hannah, Song, Eric, Flynn, Matthew, Helwig, Andreas, Gharineiat, Zahra, Seneviratne, Dinuki, Whiteside, Eliza, Shelley, Tristan, Priesler, Nils, Manalo, Allan, Mirzaghorbanali, Ali, Nourizadeh, Hadi, Roberts, Michae, Nicol, Rose, Redmond, Petrea, Lynch, Mark, Dearnaley, John, ..., Germon, Geoff. 2023. "Construction and Deconstruction: Materials and substances from 'waste'." Chemistry in Australia. (June-August 2023), pp. 16-21.
Scoping review of molecular biomarkers associated with fatigue, stress, and depression in stroke survivors: A protocol
Potter, Tarynn, Gange, Nisal, Whiteside, Eliza and Gyawali, Prajwal. 2023. "Scoping review of molecular biomarkers associated with fatigue, stress, and depression in stroke survivors: A protocol." PLoS One. 18. https://doi.org/10.1371/journal.pone.0281238.
Differences in total cognition and cerebrovascular function in female breast cancer survivors and cancer-free women
Downs, Tahnee L., Whiteside, Eliza J., Foot, Gaye, Mills, Dean E. and Bliss, Edward S.. 2023. "Differences in total cognition and cerebrovascular function in female breast cancer survivors and cancer-free women." The Breast. 69, pp. 358-365. https://doi.org/10.1016/j.breast.2023.03.018
Biomarkers to measure respiratory muscle damage following inspiratory pressure threshold loading in healthy young men
Iqbal, Muneeb, Bliss, Edward, Whiteside, Eliza, Hoffman, Ben and Mills, Dean E,. 2023. "Biomarkers to measure respiratory muscle damage following inspiratory pressure threshold loading in healthy young men." Journal of Applied Physiology. 134 (4), pp. 1038-1046. https://doi.org/10.1152/japplphysiol.00656.2022
Microneedle patches – the future of drug delivery and vaccination?
Faraji Rad, Zahra, Prewett, Philip D. and Davies, Davies. 2023. "Microneedle patches – the future of drug delivery and vaccination?" Beilstein Journal of Nanotechnology. 14, pp. 494-495. https://doi.org/10.3762/bjnano.14.40
Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle-Based Biosensors
Saifullah, Khaled Mohammed and Faraji Rad, Zahra. 2023. "Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle-Based Biosensors." Advanced Materials Interfaces. 10 (10). https://doi.org/10.1002/admi.202201763
Bioinspired Strong, Tough, and Biodegradable Poly(Vinyl Alcohol) and its Applications as Substrates for Humidity Sensors
Liu, Lei, Xu, Xiaodong, Zhu, Menghe, Cui, Xihua, Feng, Jiabing, Faraji Rad, Zahra, Wang, Hao and Song, Pingan. 2023. "Bioinspired Strong, Tough, and Biodegradable Poly(Vinyl Alcohol) and its Applications as Substrates for Humidity Sensors." Advanced Materials Technologies. https://doi.org/10.1002/admt.202201414
Development of dissolvable microneedle patches by CNC machining and micromolding for drug delivery
Malek-Khatabi, Atefeh, Faraji Rad, Zahra, Rad-Malekshahi, Mazda and Akbarijavar, Hamid. 2023. "Development of dissolvable microneedle patches by CNC machining and micromolding for drug delivery." Materials Letters. 330, pp. 1-6. https://doi.org/10.1016/j.matlet.2022.133328
Fundamentals of Anatomy and Physiology
Chruscik, Anna, Kauter, Kate, Windus, Louisa, Whiteside, Eliza and Dooley, Leanne. 2021. Fundamentals of Anatomy and Physiology . Australia. University of Southern Queensland.
Microneedle Technologies for Food and Crop Health: Recent Advances and Future Perspectives
Faraji Rad, Zahra. 2023. "Microneedle Technologies for Food and Crop Health: Recent Advances and Future Perspectives." Advanced Engineering Materials. 25 (4). https://doi.org/10.1002/adem.202201194
Embedding Authentic First Nations Content within Biomedical Science Curriculum
Myer, Sarah, Fossey, Uncle Wayne, Ward, Raelene and Whiteside, Eliza J.. 2022. "Embedding Authentic First Nations Content within Biomedical Science Curriculum." Australian Conference on Science and Mathematics Education (2022). Perth, Australia Sydney, Australia.
Fabrication and testing of polymer microneedles for transdermal drug delivery
Ebrahiminejad, Vahid, Faraji Rad, Zahra, Prewett, Philip D. and Davies, Graham J.. 2022. "Fabrication and testing of polymer microneedles for transdermal drug delivery." Beilstein Journal of Nanotechnology. 13, pp. 629-640. https://doi.org/10.3762/bjnano.13.55
Design, Development, and Testing of Polymeric Microblades: A Novel Design of Microneedles for Biomedical Applications
Ebrahiminejad, Vahid and Faraji Rad, Zahra. 2022. "Design, Development, and Testing of Polymeric Microblades: A Novel Design of Microneedles for Biomedical Applications." Advanced Materials Interfaces. 9 (29). https://doi.org/10.1002/admi.202201115
Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration
Ebrahiminejad, Vahid, Prewett, Philip D., Davies, Graham J. and Faraji Rad, Zahra. 2022. "Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration." Advanced Materials Interfaces. 9 (6), pp. 1-26. https://doi.org/10.1002/admi.202101856
Management of paediatric recurrent urinary tract infections and challenges in special patient populations
Petcu, Clara T., Stehr, Emma, Isaac, James P. and Desai, Devang. 2021. "Management of paediatric recurrent urinary tract infections and challenges in special patient populations." Australian Journal of General Practice. 50 (7), pp. 458-464. https://doi.org/10.31128/AJGP-03-21-5922
Parametric optimization of two-photon direct laser writing process for manufacturing polymeric microneedles
Faraji Rad, Zahra, Prewett, Philip D. and Davies, Graham J.. 2022. "Parametric optimization of two-photon direct laser writing process for manufacturing polymeric microneedles." Additive Manufacturing. 56, pp. 1-14. https://doi.org/10.1016/j.addma.2022.102953
Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques
Faraji Rad, Zahra, Prewett, Philip and Davies, Graham. 2021. "Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques." Manufacturing Letters. 30, pp. 39-43. https://doi.org/10.1016/j.mfglet.2021.10.007
High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays
Faraji Rad, Zahra, Prewett, Philip and Davies, Graham. 2021. "High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays." Microsystems and Nanoengineering. 7 (1), pp. 1-17. https://doi.org/10.1038/s41378-021-00298-3
An overview of microneedle applications, materials, and fabrication methods
Faraji Rad, Zahra, Prewett, Philip and Davies, Graham. 2021. "An overview of microneedle applications, materials, and fabrication methods." Beilstein Journal of Nanotechnology. 12, pp. 1034-1046. https://doi.org/10.3762/bjnano.12.77
High-fidelity replication of thermoplastic microneedles with open microfluidic channels
Faraji Rad, Zahra, Nordon, Robert E., Anthony, Carl J., Bilston, Lynne, Prewett, Philip D., Arns, Ji-Youn, Arns, Christoph H., Zhang, Liangchi and Davies, Graham J.. 2017. "High-fidelity replication of thermoplastic microneedles with open microfluidic channels." Microsystems and Nanoengineering. 3, pp. 1-11. https://doi.org/10.1038/micronano.2017.34
HearNPV susceptibility in Helicoverpa armigera and Helicoverpa punctigera strains resistant to Bt toxins Cry1Ac, Cry2Ab, and Vip3Aa
Windus, Louisa C.E., Jones, Adele M., Downes, Sharon, Walsh, Tom, Kinkema, Mark and Knight, Kristen. 2021. "HearNPV susceptibility in Helicoverpa armigera and Helicoverpa punctigera strains resistant to Bt toxins Cry1Ac, Cry2Ab, and Vip3Aa." Journal of Invertebrate Pathology. 183, pp. 1-8. https://doi.org/10.1016/j.jip.2021.107598
Large renal artery aneurysm masquerading as renal cell carcinoma
Neerhut, Thomas, Nanayakkara, Sachith, Cozman, Claudiu, Lawson, Malcom and Desai, Devang. 2022. "Large renal artery aneurysm masquerading as renal cell carcinoma." Urology Case Reports. 43. https://doi.org/10.1016/j.eucr.2022.102117
The impact of an anatomy and physiology open textbook on student satisfaction and engagement in a regional Australian university
Chruscik, Anna, Kauter, Kate, Whiteside, Anna and Windus, Louisa. 2022. "The impact of an anatomy and physiology open textbook on student satisfaction and engagement in a regional Australian university." 39th International Conference on Innovation, Practice and Research in the Use of Educational Technologies in Tertiary Education (ASCILITE 2022). Sydney, Australia 04 - 07 Dec 2022 Australia. Australasian Society for Computers in Learning in Tertiary Education (ASCILITE). https://doi.org/10.14742/APUBS.2022.183
Carbon-based nanostructures for cancer therapy and drug delivery applications
Bagheri, Babak, Surwase, Sachin S., Lee, Su Sam, Park, Heewon, Faraji Rad, Zahra, Trevaskis, Natalie L. and Kim, Yeu-Chun. 2022. "Carbon-based nanostructures for cancer therapy and drug delivery applications." Journal of Materials Chemistry B. 10 (48), pp. 9944-9967. https://doi.org/10.1039/d2tb01741e
How to do science: A guide to researching human physiology
Lexis, Louise, Julien, Brianna, Bliss, Edward, Derrington, Kate, Dooley, Leanne, Kauter, Kate, McGregor, Rowena, Myer, Sarah, Salmeron, Raquel, Suraweera, Samanthi, Whiteside, Eliza and Windus, Louisa. 2022. How to do science: A guide to researching human physiology. Australia. University of Southern Queensland.
The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype
Thomas, Patrick B., Jeffrey, Penny, Gahete, Manuel D., Whiteside, Eliza, Walpole, Carina, Maugham, Michelle, Jovanovic, Lidija, Gunter, Jennifer, Williams, Elizabeth, Nelson, Colleen, Herington, Adrian, Luque, Raul M., Veedu, Rakesh, Chopin, Lisa K. and Seim, Inge. 2021. "The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype." PEERJ. 9, pp. 1-29. https://doi.org/10.7717/peerj.10280
Regulation of the chemokine receptors CXCR7 and CXCR4 in 3-D culture models of prostate cancer
Kiss, Debra L., Windus, Louisa C. E. and Avery, Vickey M.. 2012. "Regulation of the chemokine receptors CXCR7 and CXCR4 in 3-D culture models of prostate cancer." 2012 AACR Special Conference on Advances in Prostate Cancer Research. Orlando, United States of America 06 - 09 Feb 2012 United States. https://doi.org/10.1158/1538-7445
Academic achievement and student satisfaction: moving anatomy and physiology teaching online
Chruscik, Anna, Windus, Louisa, Wang, Jianxiong, Kauter, Kate and Whiteside, Eliza. 2020. "Academic achievement and student satisfaction: moving anatomy and physiology teaching online." 2020 Australian Conference on Science and Mathematics Education (formerly UniServe Science Conference). Online 30 Sep - 02 Oct 2020 Australia.
A roof cavability classification system and its use for estimation of main caving interval in longwall mining
Mohammadi, Sodjad, Ataei, Mohammad, Kakaie, Reza, Mirzaghorbanali, Ali, Faraji Rad, Zahra and Aziz, Naj. 2020. "A roof cavability classification system and its use for estimation of main caving interval in longwall mining." Aziz, Naj and Kininmonth, Bob (ed.) 2020 Coal Operators' Conference. Wollongong, Australia 18 - 20 Feb 2019 Wollongong, Australia.
Cells and 3D printed bioscaffolds: inter-disciplinary collaborations to engage and inspire students in biomedical science
Whiteside, Eliza, Piper, Steph and Maxwell, Andrew. 2019. "Cells and 3D printed bioscaffolds: inter-disciplinary collaborations to engage and inspire students in biomedical science." 2019 Biosciences Education Australia Network Forum (BEAN19). Melbourne, Australia 08 - 10 Dec 2019
The long non-coding RNA GHSROS facilitates breast cancer cell migration and orthotopic xenograft tumour growth
Thomas, Patrick B., Seim, Inge, Jeffery, Penny L., Gahete, Manuel D., Maugham, Michelle, Crisp, Gabrielle J., Stacey, Andrew, Shah, Esha T., Walpole, Carina, Whiteside, Eliza J., Nelson, Colleen C., Herington, Adrian C., Luque, Raul M., Veedu, Rakesh N. and Chopin, Lisa K.. 2019. "The long non-coding RNA GHSROS facilitates breast cancer cell migration and orthotopic xenograft tumour growth." International Journal of Oncology. 55 (6), pp. 1223-1236. https://doi.org/10.3892/ijo.2019.4891
Microfluidic devices and fabrication
Faraji Rad, Zahra, Nordon, Robert, Davies, Graham, Anthony, Carl john and Prewett, Philip. 2020. Microfluidic devices and fabrication. 10850082
The gut-brain axis, the human gut microbiota and their integration in the development of obesity
Bliss, Edward S. and Whiteside, Eliza. 2018. "The gut-brain axis, the human gut microbiota and their integration in the development of obesity." Frontiers in Physiology. 9, pp. 1-27. https://doi.org/10.3389/fphys.2018.00900
Dysregulated expression of the human long noncoding RNA GHSROS may influence prostate cancer progression and resistance to docetaxel
Thomas, Patrick B., Jeffrey, Penny L., Manuel, Gahete D., Whiteside, Eliza J., Maugham, Michelle, Walpole, Carina, Gunter, Jennifer H., Williams, Elizabeth D., Nelson, Colleen C., Herington, Adrian C., Luque, Raul M., Veedu, Rakesh N., Chopin, Lisa K. and Seim, Inge. 2018. "Dysregulated expression of the human long noncoding RNA GHSROS may influence prostate cancer progression and resistance to docetaxel." Annual Meeting of 2018 American Association for Cancer Research (AACR 2018). Chicago, United States 14 - 18 Apr 2018 United States. American Association for Cancer Research (AACR). https://doi.org/10.1158/1538-7445.AM2018-2452
The long non-coding RNA, GHSROS, mediates prostate cancer growth
Thomas, Patrick, Walpole, Carina Maree, Jeffery, Penny, Jovanovic, Lidija, Herington, Adrian, Nelson, Colleen, Whiteside, Eliza, Veedu, Rakesh, Seim, Inge and Chopin, Lisa. 2018. "The long non-coding RNA, GHSROS, mediates prostate cancer growth ." Annual Scientific Meeting of the Endocrine Society of Australia 2016. Gold Coast, Australia 21 - 24 Aug 2016 United Kingdom . John Wiley & Sons. https://doi.org/10.1111/cen.13259
Stress, COMT polymorphisms, and depressive symptoms in older Australian women: an exploratory study
Seib, Charrlotte, Whiteside, Eliza, Voisey, Joanne, Lee, Kathryn, Alexander, Kimberly, Humphreys, Janice, Chopin, Lisa and Anderson, Debra. 2016. "Stress, COMT polymorphisms, and depressive symptoms in older Australian women: an exploratory study." Genetic Testing and Molecular Biomarkers. 20 (8), pp. 478-481. https://doi.org/10.1089/gtmb.2015.0028
Ghrelin and cancer
Chopin, Lisa, Walpole, Carina, Seim, Inge, Cunningham, Peter, Murray, Rachael, Whiteside, Eliza, Josh, Peter and Herington, Adrian. 2011. "Ghrelin and cancer." Molecular and Cellular Endocrinology. 340 (1), pp. 65-69. https://doi.org/10.1016/j.mce.2011.04.013
Ghrelin O-acyltransferase (GOAT) is expressed in prostate cancer tissues and cell lines and expression is differentially regulated in vitro by ghrelin
Seim, Inge, Jeffery, Penny L., de Amorim, Laura, Walpole, Carina M., Fung, Jenny, Whiteside, Eliza J., Lourie, Rohan, Herington, Adrian C. and Chopin, Lisa K.. 2013. "Ghrelin O-acyltransferase (GOAT) is expressed in prostate cancer tissues and cell lines and expression is differentially regulated in vitro by ghrelin." Reproductive Biology and Endocrinology. 11 (1), pp. 70-78. https://doi.org/10.1186/1477-7827-11-70
Targeting the Long Non-Coding RNA GHSROS, a Mediator of Prostate Cancer Tumour Growth, with Antisense Oligonucleotides
Thomas, Patrick B, Walpole, Carina M, Jeffrey, Penny L, Jovanovic, Lidija, Herington, Adrian C, Nelson, Colleen C, Whiteside, Eliza, Veedu, Rakesh N, Seim, Inge and Chopin, Lisa K.. 2016. "Targeting the Long Non-Coding RNA GHSROS, a Mediator of Prostate Cancer Tumour Growth, with Antisense Oligonucleotides." 17th Asia‐Pacific Prostate Cancer Conference. Australia 03 - 31 Aug 2016 United Kingdom . John Wiley & Sons.
Location of residence and breast cancer stage: a SEER population-based analysis
Brandon, Lindsay, Youl, Pip, Baade, Peter, Whiteside, Eliza and Kimlin, Michael. 2015. "Location of residence and breast cancer stage: a SEER population-based analysis." The Breast Journal. 21 (6), pp. 693-695. https://doi.org/10.1111/tbj.12499
Stress, lifestyle, and quality of life in midlife and older Australian women: results from the stress and the health of women study
Seib, Charrlotte, Whiteside, Eliza, Lee, Kathryn, Humphreys, Janice, Dao Tran, Tiet Hanh, Chopin, Lisa and Anderson, Debra. 2014. "Stress, lifestyle, and quality of life in midlife and older Australian women: results from the stress and the health of women study." Women's Health Issues. 24 (1), pp. e43-e52. https://doi.org/10.1016/j.whi.2013.11.004
A longitudinal study of the impact of chronic psychological stress on health-related quality of life and clinical biomarkers: protocol for the Australian Healthy Aging of Women Study
Seib, Charrlotte, Whiteside, Eliza J., Humphreys, Janice, Lee, Kathryn, Thomas, Patrick, Chopin, Lisa, Crisp, Gabrielle, O'Keeffe, Angela, Kimlin, Michael, Stacey, Andrew and Anderson, Debra. 2014. "A longitudinal study of the impact of chronic psychological stress on health-related quality of life and clinical biomarkers: protocol for the Australian Healthy Aging of Women Study." BMC Public Health. 14 (1), pp. 1-8. https://doi.org/10.1186/1471-2458-14-9
You don't know what you don't know: ethics and participant consent issues for eResearch users
Ostini, Jenny, Gacenga, Francis, Pocock, Celmara and Whiteside, Eliza. 2014. "You don't know what you don't know: ethics and participant consent issues for eResearch users." eResearch Australasia 2014 Conference: Towards Unified Global Research. Melbourne, Australia 27 - 31 Oct 2014 Sydney, Australia.
Multi-species sequence comparison reveals conservation of ghrelin gene-derived splice variants encoding a truncated ghrelin peptide
Seim, Inge, Jeffrey, Penny L., Thomas, Patrick B., Walpole, Carina M., Maugham, Michelle, Fung, Jenny N. T., Yap, Pei-Yi, O'Keeffe, Angela, Lai, John, Whiteside, Eliza J., Herington, Adrian C. and Chopin, Lisa K.. 2016. "Multi-species sequence comparison reveals conservation of ghrelin gene-derived splice variants encoding a truncated ghrelin peptide." Endocrine. 52 (3), pp. 609-617. https://doi.org/10.1007/s12020-015-0848-7
Cloning of a novel insulin-regulated ghrelin transcript in prostate cancer
Seim, Inge, Lubik, Amy A., Lehman, Melanie L., Tomlinson, Nadine, Whiteside, Eliza J., Herington, Adrian C., Nelson, Colleen C. and Chopin, Lisa K.. 2013. "Cloning of a novel insulin-regulated ghrelin transcript in prostate cancer." Journal of Molecular Endocrinology. 50 (2), pp. 179-191. https://doi.org/10.1530/JME-12-0150
Identification of a long non-coding RNA gene, growth hormone secretagogue receptor opposite strand, which stimulates cell migration in non-small cell lung cancer cell lines
Whiteside, Eliza J., Seim, Inge, Pauli, Jana P., O'Keefe, Angela J., Thomas, Patrick B., Carter, Shea L., Walpole, Carina M., Fung, Jenny N. T., Josh, Peter, Herington, Adrian C. and Chopin, Lisa K.. 2013. "Identification of a long non-coding RNA gene, growth hormone secretagogue receptor opposite strand, which stimulates cell migration in non-small cell lung cancer cell lines." International Journal of Oncology. 43 (2), pp. 566-574. https://doi.org/10.3892/ijo.2013.1969
Chemokine receptor expression on integrin-mediated stellate projections of prostate cancer cells in 3D culture
Kiss, Debra, Windus, Louisa C. E. and Avery, Vicky. 2013. "Chemokine receptor expression on integrin-mediated stellate projections of prostate cancer cells in 3D culture." Cytokine. 64 (1), pp. 122-130. https://doi.org/10.1016/j.cyto.2013.07.012
Bone-stromal cells up-regulate tumourigenic markers in a tumour-stromal 3D model of prostate cancer
Windus, Louisa C. E., Glover, Tristan T. and Avery, V.. 2013. "Bone-stromal cells up-regulate tumourigenic markers in a tumour-stromal 3D model of prostate cancer." Molecular Cancer. 12, pp. 1-19. https://doi.org/10.1186/1476-4598-12-112
PCaAnalyser: A 2D-Image Analysis Based Module for Effective Determination of Prostate Cancer Progression in 3D Culture
Hoque, Md Tamjidul, Windus, Louisa C. E., Lovitt, Carrie J. and Avery, Vicky. 2013. "PCaAnalyser: A 2D-Image Analysis Based Module for Effective Determination of Prostate Cancer Progression in 3D Culture." PLoS One. 8 (11), pp. 1-13. https://doi.org/10.1371/journal.pone.0079865
In vivo biomarker expression patterns are preserved in 3D cultures of Prostate Cancer
Windus, Louisa C. E., Kiss, Debra L., Glover, Tristan T. and Avery, Vicky M.. 2012. "In vivo biomarker expression patterns are preserved in 3D cultures of Prostate Cancer." Experimental Cell Research. 318 (19), pp. 2507-2519. https://doi.org/10.1016/j.yexcr.2012.07.013
Correction of aberrant axon growth in the developing mouse olfactory bulb
Chan, C., Ekberg, J., Lineburg, K., Scott, S., Chehrehasa, F., Windus, L., Claxton, C., Mackay-Sim, A., Key, B. and St John, J.. 2011. "Correction of aberrant axon growth in the developing mouse olfactory bulb." Molecular and Cellular Neuroscience. 46 (1), pp. 282-295. https://doi.org/10.1016/j.mcn.2010.09.012
OMP-ZsGreen fluorescent protein transgenic mice for visualisation of olfactory sensory neurons in vivo and in vitro
Ekberg, J., Amaya, D., Chehrehasa, F., Lineburg, K., Claxton, C., Windus, Louisa C. E., Key, B., Mackay-Sim, A. and St John, J.. 2011. "OMP-ZsGreen fluorescent protein transgenic mice for visualisation of olfactory sensory neurons in vivo and in vitro." Journal of Neuroscience Methods. 196 (1), pp. 88-98. https://doi.org/10.1016/j.jneumeth.2011.01.008
Stimulation of olfactory ensheathing cell motility enhances olfactory axon growth
Windus, Louisa C. E., Chehrehasa, Fatemah, Lineburg, Katie, Claxton, Christina, Mackay-Sim, Alan, Key, Brian and St John, James. 2011. "Stimulation of olfactory ensheathing cell motility enhances olfactory axon growth." Cellular and Molecular Life Sciences. 68 (19), pp. 3233-3247. https://doi.org/10.1007/s00018-011-0630-9
Copper, Nickel, and Zinc Cyclam−Amino Acid and Cyclam−Peptide Complexes May Be Synthesized with 'Click' Chemistry and Are Noncytotoxic
Yu, Mingfeng, Price, Jason, Jensen, Paul D., Lovitt, Carrie J., Shelper, Todd, Duffy, Sandra, Windus, Louisa C., Avery, Vicky, Rutledge, Peter and Todd, Matthew. 2011. "Copper, Nickel, and Zinc Cyclam−Amino Acid and Cyclam−Peptide Complexes May Be Synthesized with 'Click' Chemistry and Are Noncytotoxic." Inorganic Chemistry: including bioinorganic chemistry. 50, pp. 12823-12835. https://doi.org/10.1021/ic2020012
Lamellipodia mediate the heterogeneity of central olfactory ensheathing cell interactions
Windus, Louisa C. E., Lineburg, Katie, Scott, Susan, Claxton, Christina, Mackay-Sim, Alan, Key, Brian and St John, James. 2010. "Lamellipodia mediate the heterogeneity of central olfactory ensheathing cell interactions." Cellular and Molecular Life Sciences. 67 (10), pp. 1735-1750. https://doi.org/10.1007/s00018-010-0280-3
Olfactory glia enhance neonatal axon regeneration
Chehrehasa, Fatemah, Windus, Louisa C. E., Ekberg, Jenny, Scott, Susan, Amaya, Daniel, Mackay-Sim, Alan and St John, James. 2010. "Olfactory glia enhance neonatal axon regeneration." Molecular and Cellular Neuroscience. 45 (3), pp. 277-288. https://doi.org/10.1016/j.mcn.2010.07.002
Motile membrane protrusions regulate cell-cell adhesion and migration of olfactory ensheathing glia
Windus, Louisa C. E., Claxton, C., Allen, C., Key, B. and St John, J.. 2007. "Motile membrane protrusions regulate cell-cell adhesion and migration of olfactory ensheathing glia." Glia. 55 (15), pp. 1708-1719. https://doi.org/10.1002/glia.20586
Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway
Matigan, N., Windus, L., Smith, H., Filippich, C., Pantelis, C., McGrath, J., Mowry, B. and Hayward, N.. 2007. "Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway." Molecular Psychiatry. 12 (9), pp. 815-825. https://doi.org/10.1038/sj.mp.4001998
Evidence of altered prefrontal–thalamic circuitry in schizophrenia: An optimized diffusion MRI study
Rose, S., Chalk, J., Janke, A., Strudwick, M., Windus, Louisa C., Hannah, D., McGrath, J., Pantelis, C., Wood, S. and Mowry, B.. 2006. "Evidence of altered prefrontal–thalamic circuitry in schizophrenia: An optimized diffusion MRI study." NeuroImage. 32 (1), pp. 16-22. https://doi.org/10.1016/j.neuroimage.2006.03.003
Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia
Handoko, HY, Nyholt, DR, Hayward, NK, Nertney, DA, Hannah, DE, Windus, LC, McCormack, CM, Smith, HJ, Flippich, C, James, MR and Mowry, BJ. 2004. "Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia." Molecular Psychiatry. 10 (6), pp. 589-597. https://doi.org/10.1038/sj.mp.4001606
Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis?
Pantaleon, M., Whiteside, E. J., Harvey, M.B., Barnard, R.T., Waters, M.J. and Kaye, P.L.. 1997. "Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis?" University of Adelaide. 94 (10), pp. 5125-5130. https://doi.org/10.1073/pnas.94.10.5125