Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration

Article

Ebrahiminejad, Vahid, Prewett, Philip D., Davies, Graham J. and Faraji Rad, Zahra. 2022. "Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration." Advanced Materials Interfaces. 9 (6), pp. 1-26. https://doi.org/10.1002/admi.202101856
Article Title

Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration

ERA Journal ID210043
Article CategoryArticle
AuthorsEbrahiminejad, Vahid (Author), Prewett, Philip D. (Author), Davies, Graham J. (Author) and Faraji Rad, Zahra (Author)
Journal TitleAdvanced Materials Interfaces
Journal Citation9 (6), pp. 1-26
Article Number2101856
Number of Pages26
Year2022
Place of PublicationGermany
ISSN2196-7350
Digital Object Identifier (DOI)https://doi.org/10.1002/admi.202101856
Web Address (URL)https://onlinelibrary.wiley.com/doi/10.1002/admi.202101856
Abstract

In the past two decades, microneedles have been extensively studied for transdermal delivery of drug or vaccines and for bio-fluid extraction. Microneedle-based devices consist of micron-size needles that are arranged on a small patch. Despite ongoing advances in microneedle technology, one of the major problems associated with transdermal delivery or sampling is that many of the microneedle patches are not able to fully penetrate the skin surface and reach the epidermis layer of skin. In this regard, for an optimal and effective penetration—painless and safe—it is crucial to consider complex skin mechanics and how it impacts microneedle design and insertion practice. Various types of skin modelling and insertion simulations are considered, followed by discussion of ways of improving microneedle robustness, reduction of insertion force, and enhancement of penetration efficiency.

Keywordsdrug delivery; microneedle insertion forces; microneedles; penetration efficiency of microneedle arrays into skin; point-of-care diagnostics; skin mechanics
Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020401707. Solid mechanics
401705. Microelectromechanical systems (MEMS)
400303. Biomechanical engineering
400302. Biomaterials
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Byline AffiliationsSchool of Mechanical and Electrical Engineering
University of Birmingham, United Kingdom
University of New South Wales
Institution of OriginUniversity of Southern Queensland
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