Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration

Article


Ebrahiminejad, Vahid, Prewett, Philip D., Davies, Graham J. and Faraji Rad, Zahra. 2022. "Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration." Advanced Materials Interfaces. 9 (6), pp. 1-26. https://doi.org/10.1002/admi.202101856
Article Title

Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration

ERA Journal ID210043
Article CategoryArticle
AuthorsEbrahiminejad, Vahid (Author), Prewett, Philip D. (Author), Davies, Graham J. (Author) and Faraji Rad, Zahra (Author)
Journal TitleAdvanced Materials Interfaces
Journal Citation9 (6), pp. 1-26
Article Number2101856
Number of Pages26
Year2022
PublisherJohn Wiley & Sons
Place of PublicationGermany
ISSN2196-7350
Digital Object Identifier (DOI)https://doi.org/10.1002/admi.202101856
Web Address (URL)https://onlinelibrary.wiley.com/doi/10.1002/admi.202101856
Abstract

In the past two decades, microneedles have been extensively studied for transdermal delivery of drug or vaccines and for bio-fluid extraction. Microneedle-based devices consist of micron-size needles that are arranged on a small patch. Despite ongoing advances in microneedle technology, one of the major problems associated with transdermal delivery or sampling is that many of the microneedle patches are not able to fully penetrate the skin surface and reach the epidermis layer of skin. In this regard, for an optimal and effective penetration—painless and safe—it is crucial to consider complex skin mechanics and how it impacts microneedle design and insertion practice. Various types of skin modelling and insertion simulations are considered, followed by discussion of ways of improving microneedle robustness, reduction of insertion force, and enhancement of penetration efficiency.

Keywordsdrug delivery; microneedle insertion forces; microneedles; penetration efficiency of microneedle arrays into skin; point-of-care diagnostics; skin mechanics
Related Output
Is part ofDesign and fabrication of microneedle patches, microblades and featured insertion applicator for optimising transdermal drug delivery
Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020401707. Solid mechanics
401705. Microelectromechanical systems (MEMS)
400303. Biomechanical engineering
400302. Biomaterials
Public Notes

Files associated with this item cannot be displayed due to copyright restrictions.

This article is part of a UniSQ Thesis by publication. See Related Output.

Byline AffiliationsSchool of Mechanical and Electrical Engineering
University of Birmingham, United Kingdom
University of New South Wales
Institution of OriginUniversity of Southern Queensland
Permalink -

https://research.usq.edu.au/item/q7105/microneedle-arrays-for-drug-delivery-and-diagnostics-toward-an-optimized-design-reliable-insertion-and-penetration

  • 93
    total views
  • 3
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Export as

Related outputs

Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle-Based Biosensors
Faraji Rad, Zahra and Saifullah, Khaled. 2023. "Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle-Based Biosensors." Advanced Materials Interfaces. 10 (10). https://doi.org/10.1002/admi.202201763
The role of microneedles in the healing of chronic wounds
Ghiyasi, Yasaman, Prewett, Philip D, Davies, Graham J and Faraji Rad, Zahra. 2023. "The role of microneedles in the healing of chronic wounds." International Journal of Pharmaceutics. 641. https://doi.org/10.1016/j.ijpharm.2023.123087
Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery
Malek-Khatabi, A., Razavi, M.S., Abdollahi, A., Rahimzadeghan, M., Moammeri, F., Sheikhi, M., Tavakoli, M., Rad-Malekshahi, M. and Faraji Rad, Z.. 2023. "Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery." Biomaterials Science. 11 (16), pp. 5390-5409. https://doi.org/10.1039/D3BM00795B
Microneedle patches – the future of drug delivery and vaccination?
Faraji Rad, Zahra, Prewett, Philip D. and Davies, Davies. 2023. "Microneedle patches – the future of drug delivery and vaccination?" Beilstein Journal of Nanotechnology. 14, pp. 494-495. https://doi.org/10.3762/bjnano.14.40
Bioinspired Strong, Tough, and Biodegradable Poly(Vinyl Alcohol) and its Applications as Substrates for Humidity Sensors
Liu, Lei, Xu, Xiaodong, Zhu, Menghe, Cui, Xihua, Feng, Jiabing, Faraji Rad, Zahra, Wang, Hao and Song, Pingan. 2023. "Bioinspired Strong, Tough, and Biodegradable Poly(Vinyl Alcohol) and its Applications as Substrates for Humidity Sensors." Advanced Materials Technologies. https://doi.org/10.1002/admt.202201414
Development of dissolvable microneedle patches by CNC machining and micromolding for drug delivery
Malek-Khatabi, Atefeh, Faraji Rad, Zahra, Rad-Malekshahi, Mazda and Akbarijavar, Hamid. 2023. "Development of dissolvable microneedle patches by CNC machining and micromolding for drug delivery." Materials Letters. 330, pp. 1-6. https://doi.org/10.1016/j.matlet.2022.133328
Microneedle Technologies for Food and Crop Health: Recent Advances and Future Perspectives
Faraji Rad, Zahra. 2023. "Microneedle Technologies for Food and Crop Health: Recent Advances and Future Perspectives." Advanced Engineering Materials. 25 (4). https://doi.org/10.1002/adem.202201194
Fabrication and testing of polymer microneedles for transdermal drug delivery
Ebrahiminejad, Vahid, Faraji Rad, Zahra, Prewett, Philip D. and Davies, Graham J.. 2022. "Fabrication and testing of polymer microneedles for transdermal drug delivery." Beilstein Journal of Nanotechnology. 13, pp. 629-640. https://doi.org/10.3762/bjnano.13.55
Design, Development, and Testing of Polymeric Microblades: A Novel Design of Microneedles for Biomedical Applications
Ebrahiminejad, Vahid and Faraji Rad, Zahra. 2022. "Design, Development, and Testing of Polymeric Microblades: A Novel Design of Microneedles for Biomedical Applications." Advanced Materials Interfaces. 9 (29). https://doi.org/10.1002/admi.202201115
Parametric optimization of two-photon direct laser writing process for manufacturing polymeric microneedles
Faraji Rad, Zahra, Prewett, Philip D. and Davies, Graham J.. 2022. "Parametric optimization of two-photon direct laser writing process for manufacturing polymeric microneedles." Additive Manufacturing. 56, pp. 1-14. https://doi.org/10.1016/j.addma.2022.102953
Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques
Faraji Rad, Zahra, Prewett, Philip and Davies, Graham. 2021. "Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques." Manufacturing Letters. 30, pp. 39-43. https://doi.org/10.1016/j.mfglet.2021.10.007
High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays
Faraji Rad, Zahra, Prewett, Philip and Davies, Graham. 2021. "High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays." Microsystems and Nanoengineering. 7 (1), pp. 1-17. https://doi.org/10.1038/s41378-021-00298-3
An overview of microneedle applications, materials, and fabrication methods
Faraji Rad, Zahra, Prewett, Philip and Davies, Graham. 2021. "An overview of microneedle applications, materials, and fabrication methods." Beilstein Journal of Nanotechnology. 12, pp. 1034-1046. https://doi.org/10.3762/bjnano.12.77
High-fidelity replication of thermoplastic microneedles with open microfluidic channels
Faraji Rad, Zahra, Nordon, Robert E., Anthony, Carl J., Bilston, Lynne, Prewett, Philip D., Arns, Ji-Youn, Arns, Christoph H., Zhang, Liangchi and Davies, Graham J.. 2017. "High-fidelity replication of thermoplastic microneedles with open microfluidic channels." Microsystems and Nanoengineering. 3, pp. 1-11. https://doi.org/10.1038/micronano.2017.34
Carbon-based nanostructures for cancer therapy and drug delivery applications
Bagheri, Babak, Surwase, Sachin S., Lee, Su Sam, Park, Heewon, Faraji Rad, Zahra, Trevaskis, Natalie L. and Kim, Yeu-Chun. 2022. "Carbon-based nanostructures for cancer therapy and drug delivery applications." Journal of Materials Chemistry B. 10 (48), pp. 9944-9967. https://doi.org/10.1039/d2tb01741e
A roof cavability classification system and its use for estimation of main caving interval in longwall mining
Mohammadi, Sodjad, Ataei, Mohammad, Kakaie, Reza, Mirzaghorbanali, Ali, Faraji Rad, Zahra and Aziz, Naj. 2020. "A roof cavability classification system and its use for estimation of main caving interval in longwall mining." Aziz, Naj and Kininmonth, Bob (ed.) 2020 Coal Operators' Conference. Wollongong, Australia 18 - 20 Feb 2019 Wollongong, Australia.
Potential Application of Wire Woven Mesh as Tower Packing Support-Computational Approach
Ebrahiminejad, Vahid and Sharifian Barforoush, Ahmad. 2020. "Potential Application of Wire Woven Mesh as Tower Packing Support-Computational Approach." 22nd International Conference on Composite Materials (ICCM-22). Melbourne, Australia 11 - 16 Aug 2019 Australia.
Microfluidic devices and fabrication
Faraji Rad, Zahra, Nordon, Robert, Davies, Graham, Anthony, Carl john and Prewett, Philip. 2020. Microfluidic devices and fabrication. 10850082