Mechanics of dissolving microneedles insertion into the skin: Finite element and experimental analyses

Article

Babapour, Fatemeh, Faraji Rad, Zahra and Ganji, Fariba. 2024. "Mechanics of dissolving microneedles insertion into the skin: Finite element and experimental analyses." Journal of Applied Polymer Science. 141 (38). https://doi.org/10.1002/app.55973
Article Title

Mechanics of dissolving microneedles insertion into the skin: Finite element and experimental analyses

ERA Journal ID1671
Article CategoryArticle
AuthorsBabapour, Fatemeh, Faraji Rad, Zahra and Ganji, Fariba
Journal TitleJournal of Applied Polymer Science
Journal Citation141 (38)
Article Numbere55973
Number of Pages13
Year2024
PublisherJohn Wiley & Sons
Place of PublicationUnited States
ISSN0021-8995
1097-4628
Digital Object Identifier (DOI)https://doi.org/10.1002/app.55973
Web Address (URL)https://onlinelibrary.wiley.com/doi/10.1002/app.55973
AbstractTransdermal drug delivery using dissolving microneedles (DMNs) is promising due to increased patient compliance and safety. This article presents a comprehensive simulation and experimental analysis of DMNs with varying tip and base diameters and polymers. The objective of the simulation study is to identify the optimal tip and base diameter of DMNs, as well as the most suitable polymer, for achieving maximum penetration depth. The simulation results showed that the compound consisting of polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) in a ratio of 2:1, with a tip radius of 17.5 μm and a base radius of 150 μm, achieved the deepest penetration among the different types of polymers investigated (including PVA, hyaluronic acid (HA), and PVA/PVP in ratios of 1:1 and 1:2). In addition, mechanical and skin penetration experiments were performed on PVA/PVP 2:1 DMNs with varying concentrations of 4, 7, 10, and 15% w/w to determine the optimal polymer concentration. The results of this study indicated that the optimal composition, considering the viscosity of the polymer solution and the simplicity of filling the silicone negative molds, is a PVA/PVP 2:1 with a concentration of 7% w/w.
Keywordsdissolving microneedles; penetration depth; polymer concentration; simulation; transdermal drug delivery
Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020401705. Microelectromechanical systems (MEMS)
Byline AffiliationsTarbiat Modares University, Iran
School of Engineering
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